Showing Compound Card for Magnesium (CDB005083)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraProtein targetPathwaysConcentrationsLinksReferencesenzymes (378)transporters (49) Show 711 proteinsXML
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Record Information
Version1.0
Created at2020-04-17 19:07:37 UTC
Updated at2020-12-07 19:11:32 UTC
CannabisDB IDCDB005083
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameMagnesium
DescriptionMagnesium, also known as magnesium ion or MG2+, belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom. Magnesium is possibly neutral. Magnesium exists in all living species, ranging from bacteria to humans. In humans, magnesium is involved in mercaptopurine action pathway. Outside of the human body, Magnesium has been detected, but not quantified in, several different foods, such as cereals and cereal products, sunburst squash (pattypan squash), barley, gram beans, and lingonberries. This could make magnesium a potential biomarker for the consumption of these foods. Magnesium, with regard to humans, has been found to be associated with several diseases such as multiple sclerosis, bartter syndrome, type 1, antenatal, seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (sesames), and bartter syndrome, type 2, antenatal; magnesium has also been linked to the inborn metabolic disorder primary hypomagnesemia. Magnesium is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
MAGNESIUM ionChEBI
Magnesium, doubly charged positive ionChEBI
Magnesium, ion (MG(2+))ChEBI
MG(2+)ChEBI
MG2+ChEBI
Magnesium(2+)Kegg
Magnesium ionsHMDB
Neuropeptide y (1-27)HMDB
Chemical FormulaMg
Average Molecular Weight24.31
Monoisotopic Molecular Weight23.985
IUPAC Namemagnesium(2+) ion
Traditional Namemagnesium(2+) ion
CAS Registry Number7439-95-4
SMILES
[Mg++]
InChI Identifier
InChI=1S/Mg/q+2
InChI KeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkaline earth metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkaline earth metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkaline earth metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point651 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.57ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Pathways
Pathways
Protein Targets
Enzymes
Transporters
Metal Bindings
Receptors
Transcriptional Factors
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified5.442 mg/g dry wt
    • David S. Wishart,...
 details
GabriolaDetected and Quantified4.053 mg/g dry wt
    • David S. Wishart,...
 details
Island HoneyDetected and Quantified6.619 mg/g dry wt
    • David S. Wishart,...
 details
QuadraDetected and Quantified4.158 mg/g dry wt
    • David S. Wishart,...
 details
Sensi StarDetected and Quantified3.841 mg/g dry wt
    • David S. Wishart,...
 details
Tangerine DreamDetected and Quantified4.013 mg/g dry wt
    • David S. Wishart,...
 details
HMDB IDHMDB0000547
DrugBank IDDB01378
Phenol Explorer Compound IDNot Available
FoodDB IDFDB031004
KNApSAcK IDNot Available
Chemspider ID865
KEGG Compound IDC00305
BioCyc IDMG%2b2
BiGG IDNot Available
Wikipedia LinkMagnesium
METLIN IDNot Available
PubChem Compound888
PDB IDNot Available
ChEBI ID18420
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 711 proteins in total.

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Enzymes

Enzyme Details
1. UMP-CMP kinase
General function:
Involved in ATP binding
Specific function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:
CMPK1
Uniprot ID:
P30085
Molecular weight:
20180.12
Enzyme Details
2. Cytosolic 5'-nucleotidase 1B
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
Enzyme Details
3. Cytosolic 5'-nucleotidase 1A
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
Enzyme Details
4. 5'(3')-deoxyribonucleotidase, cytosolic type
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
Enzyme Details
5. 5'(3')-deoxyribonucleotidase, mitochondrial
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
Enzyme Details
6. Ectonucleoside triphosphate diphosphohydrolase 1
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
Enzyme Details
7. Ectonucleoside triphosphate diphosphohydrolase 3
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
Enzyme Details
8. Alkaline phosphatase, placental type
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPP
Uniprot ID:
P05187
Molecular weight:
57953.31
Enzyme Details
9. Intestinal-type alkaline phosphatase
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPI
Uniprot ID:
P09923
Molecular weight:
56811.695
Enzyme Details
10. Alkaline phosphatase, tissue-nonspecific isozyme
General function:
Involved in catalytic activity
Specific function:
This isozyme may play a role in skeletal mineralization.
Gene Name:
ALPL
Uniprot ID:
P05186
Molecular weight:
57304.435

Transporters

Enzyme Details
1. Plasma membrane calcium-transporting ATPase 3
General function:
Involved in ATP binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Gene Name:
ATP2B3
Uniprot ID:
Q16720
Molecular weight:
134196.025
Enzyme Details
2. Sodium/potassium-transporting ATPase subunit beta-3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
Enzyme Details
3. Plasma membrane calcium-transporting ATPase 1
General function:
Involved in ATP binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Gene Name:
ATP2B1
Uniprot ID:
P20020
Molecular weight:
129515.035
Enzyme Details
4. Sodium/potassium-transporting ATPase subunit beta-2
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9
Enzyme Details
5. Plasma membrane calcium-transporting ATPase 2
General function:
Involved in ATP binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Gene Name:
ATP2B2
Uniprot ID:
Q01814
Molecular weight:
136875.18
Enzyme Details
6. Sodium/potassium-transporting ATPase subunit beta-1
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane
Gene Name:
ATP1B1
Uniprot ID:
P05026
Molecular weight:
35061.1
Enzyme Details
7. Transient receptor potential cation channel subfamily M member 6
General function:
Involved in ion channel activity
Specific function:
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region
Gene Name:
TRPM6
Uniprot ID:
Q9BX84
Molecular weight:
231705.9
Enzyme Details
8. Calcium-transporting ATPase type 2C member 2
General function:
Involved in ATP binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity).
Gene Name:
ATP2C2
Uniprot ID:
O75185
Molecular weight:
103186.475
Enzyme Details
9. Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
General function:
Involved in ATP binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Gene Name:
ATP2A3
Uniprot ID:
Q93084
Molecular weight:
109255.08
Enzyme Details
10. Protein ATP1B4
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit
Gene Name:
ATP1B4
Uniprot ID:
Q9UN42
Molecular weight:
41597.4

Only showing the first 10 proteins. There are 711 proteins in total.

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