| Identification |
|---|
| HMDB Protein ID
| CDBP00890 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein O-mannosyl-transferase 2 |
| Description
| Not Available |
| Synonyms
|
- Dolichyl-phosphate-mannose--protein mannosyltransferase 2
|
| Gene Name
| POMT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mannosyltransferase activity |
| Specific Function
| Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
|
| GO Classification
|
| Biological Process |
| protein O-linked glycosylation |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| mannosyltransferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| metal ion binding |
| dolichyl-phosphate-mannose-protein mannosyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid o-linked glycosylation |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Other types of O-glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24 |
| SNPs
| POMT2 |
| Gene Sequence
|
>2253 bp
ATGCCGCCGGCCACGGGCGGAGGCCTGGCAGAGTCCGAGCTGCGTCCCCGGAGGGGCCGC
TGTGGCCCCCAGGCTGCTAGGGCCGCAGGCCGGGACGTGGCCGCTGAGGCTGTGGCGCGA
AGCCCCAAACGGCCTGCTTGGGGCTCACGGCGCTTCGAGGCGGTCGGCTGGTGGGCCCTG
CTGGCCTTGGTGACGCTGCTGTCCTTCGCCACCCGCTTCCACCGCTTGGACGAGCCGCCG
CACATCTGTTGGGATGAGACTCACTTTGGAAAAATGGGAAGTTACTATATCAACCGTACA
TTTTTCTTTGATGTGCACCCGCCCCTGGGAAAGATGCTGATAGGTCTTGCTGGCTACCTG
AGTGGATATGATGGTACCTTTTTGTTCCAGAAGCCTGGGGATAAATATGAGCATCACAGC
TACATGGGAATGAGAGGATTCTGTGCATTCCTTGGCTCCTGGCTGGTCCCCTTTGCCTAC
CTCACTGTACTGGATCTGTCCAAGTCCCTCTCGGCAGCACTGCTCACAGCTGCCCTCCTC
ACCTTTGACACGGGATGCCTCACTCTGTCCCAGTACATCCTCCTTGACCCCATCCTGATG
TTCTTCATCATGGCTGCCATGCTGAGCATGGTCAAGTACAACTCTTGCGCCGACAGGCCC
TTCTCTGCCCCCTGGTGGTTCTGGCTCAGCCTGACTGGCGTTAGTCTTGCTGGTGCTTTA
GGGGTCAAGTTTGTTGGCCTCTTTATCATCCTTCAAGTGGGGCTGAACACCATTGCAGAC
CTTTGGTACCTGTTCGGAGACCTCAGTCTTTCATTGGTGACTGTGGGAAAACACCTGACT
GCTCGTGTCCTGTGCCTCATAGTGCTGCCCCTGGCTCTCTATACAGCCACCTTTGCTGTT
CACTTCATGGTGCTGAGTAAAAGTGGCCCTGGTGACGGTTTCTTCAGTTCTGCCTTCCAG
GCCCGGCTTTCAGGGAACAACCTGCACAATGCTTCCATCCCTGAACACCTGGCCTACGGC
TCTGTGATCACTGTGAAGAACCTCCGGATGGCCATCGGCTATCTGCACTCCCACAGGCAC
CTCTACCCCGAGGGCATTGGTGCCCGTCAGCAGCAGGTCACCACCTATTTGCACAAGGAC
TACAACAACCTGTGGATTATCAAGAAACATAACACAAACTCAGATCCCCTAGACCCTTCC
TTCCCAGTGGAGTTTGTAAGACATGGAGACATTATTCGACTAGAACACAAAGAAACTTCC
CGGAACTTGCACAGTCACTATCATGAGGCCCCCATGACCCGGAAGCACTATCAGGTCACC
GGCTATGGCATAAATGGAACAGGGGACTCAAATGATTTCTGGCGGATTGAGGTCGTAAAC
AGAAAATTTGGAAACCGGATCAAAGTGCTGAGAAGTCGAATTCGCTTCATCCATTTGGTC
ACAGGTTGTGTCCTGGGCTCCTCGGGAAAGGTTCTGCCCAAGTGGGGCTGGGAGCAGTTG
GAAGTTACTTGCACCCCATACCTGAAAGAAACCCTCAACTCCATCTGGAATGTGGAGGAC
CATATCAATCCCAAGTTGCCAAACATCAGCCTGGATGTGCTACAGCCCAGTTTTCCTGAG
ATCTTGCTGGAATCCCACATGGTCATGATCCGGGGGAACAGTGGCCTCAAACCCAAGGAC
AATGAGTTCACGTCCAAACCCTGGCACTGGCCTATCAACTATCAGGGCCTACGCTTCTCA
GGGGTCAATGACACAGATTTCCGAGTCTATCTGCTTGGCAACCCGGTGGTTTGGTGGCTG
AATCTGTTGAGCATCGCCCTCTACCTCCTCTCAGGGAGCATCATTGCTGTAGCCATGCAG
AGAGGGGCACGGCTGCCAGCGGAGGTTGCAGGGTTGTCCCAGGTCCTGCTGCGAGGAGGC
GGCCAGGTCCTGCTCGGCTGGACACTCCATTACTTCCCGTTTTTCCTGATGGGCCGGGTC
CTCTACTTCCACCACTACTTCCCAGCCATGCTCTTCTCAAGCATGTTGACAGGCATTCTG
TGGGACACCCTCCTGCGGCTCTGTGCCTGGGGCTTGGCCTCATGGCCCCTGGCGAGGGGC
ATACATGTGGCGGGAATCCTGAGCCTGCTCCTGGGAACTGCCTACAGCTTCTACCTCTTC
CACCCTCTGGCTTACGGGATGGTTGGTCCCCTGGCCCAGGACCCCCAAAGTCCAATGGCA
GGACTAAGGTGGCTGGACTCATGGGACTTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 750 |
| Molecular Weight
| 84213.155 |
| Theoretical pI
| 9.152 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein O-mannosyl-transferase 2
MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKRPAWGSRRFEAVGWWAL
LALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYL
SGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALL
TFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGAL
GVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAV
HFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRH
LYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPSFPVEFVRHGDIIRLEHKETS
RNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLV
TGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNISLDVLQPSFPE
ILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWL
NLLSIALYLLSGSIIAVAMQRGARLPAEVAGLSQVLLRGGGQVLLGWTLHYFPFFLMGRV
LYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLF
HPLAYGMVGPLAQDPQSPMAGLRWLDSWDF
|
| External Links |
|---|
| GenBank ID Protein
| 32455271 |
| UniProtKB/Swiss-Prot ID
| Q9UKY4 |
| UniProtKB/Swiss-Prot Entry Name
| POMT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_013382.5 |
| GeneCard ID
| POMT2 |
| GenAtlas ID
| POMT2 |
| HGNC ID
| HGNC:19743 |
| References |
|---|
| General References
| Not Available |