Identification
HMDB Protein ID CDBP02431
Secondary Accession Numbers Not Available
Name Inorganic pyrophosphatase 2, mitochondrial
Description Not Available
Synonyms
  1. PPase 2
  2. Pyrophosphatase SID6-306
  3. Pyrophosphate phospho-hydrolase 2
Gene Name PPA2
Protein Type Enzyme
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Not Available
GO Classification
Biological Process
diphosphate metabolic process
tRNA aminoacylation for protein translation
phosphate-containing compound metabolic process
Cellular Component
mitochondrial matrix
Component
cell part
intracellular part
cytoplasm
Function
inorganic diphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
magnesium ion binding
Molecular Function
magnesium ion binding
inorganic diphosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
Cellular Location
  1. Mitochondrion (Potential)
Pathways
Gene Properties
Chromosome Location 4
Locus 4q25
SNPs PPA2
Gene Sequence
>1005 bp
ATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTG
GGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGC
GGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAACTGGTCACTACATT
TCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATG
AAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGG
TGGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATAT
GTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATGG
AATTATGGTACCCTCCCTCAGACTTGGGAAGATCCCCATGAAAAAGATAAGAGCACGAAC
TGCTTTGGAGATAATGATCCTATTGATGTTTGCGAAATAGGCTCAAAGATTCTTTCTTGT
GGAGAAGTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACA
GATTGGAAATTAATTGCTATCAATGCGAATGATCCTGAAGCCTCAAAGTTTCATGATATT
GATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTA
TATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAAC
AAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATG
AAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTC
CGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAA
GAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGA
Protein Properties
Number of Residues 334
Molecular Weight 34657.47
Theoretical pI 8.45
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Inorganic pyrophosphatase 2, mitochondrial
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC
GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
GenBank ID Protein 29171702
UniProtKB/Swiss-Prot ID Q9H2U2
UniProtKB/Swiss-Prot Entry Name IPYR2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_176869.2
GeneCard ID PPA2
GenAtlas ID PPA2
HGNC ID HGNC:28883
References
General References Not Available