Cannabis Compound Database: Showing Protein cAMP-dependent protein kinase catalytic subunit beta (CDBP01315)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01315

Secondary Accession Numbers

Not Available

Name

cAMP-dependent protein kinase catalytic subunit beta

Description

Not Available

Synonyms

PKA C-beta

Gene Name

PRKACB

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein serine/threonine kinase activity

Specific Function

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux

GO Classification

Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
phosphorus metabolic process
phosphate metabolic process

Cellular Location

Nucleus
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin		Not Available
Corticotropin Activation of Cortisol Production		Not Available
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin		Not Available
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin		Not Available
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine		Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1p36.1

SNPs

PRKACB

Gene Sequence

>1056 bp
ATGGGGAACGCGGCGACCGCCAAGAAAGGCAGCGAGGTGGAGAGCGTGAAAGAGTTTCTA
GCCAAAGCCAAAGAAGACTTTTTGAAAAAATGGGAGAATCCAACTCAGAATAATGCCGGA
CTTGAAGATTTTGAAAGGAAAAAAACCCTTGGAACAGGTTCATTTGGAAGAGTCATGTTG
GTAAAACACAAAGCCACTGAACAGTATTATGCCATGAAGATCTTAGATAAGCAGAAGGTT
GTTAAACTGAAGCAAATAGAGCATACTTTGAATGAGAAAAGAATATTACAGGCAGTGAAT
TTTCCTTTCCTTGTTCGACTGGAGTATGCTTTTAAGGATAATTCTAATTTATACATGGTT
ATGGAATATGTCCCTGGGGGTGAAATGTTTTCACATCTAAGAAGAATTGGAAGGTTCAGT
GAGCCCCATGCACGGTTCTATGCAGCTCAGATAGTGCTAACATTCGAGTACCTCCATTCA
CTAGACCTCATCTACAGAGATCTAAAACCTGAAAATCTCTTAATTGACCATCAAGGCTAT
ATCCAGGTCACAGACTTTGGGTTTGCCAAAAGAGTTAAAGGCAGAACTTGGACATTATGT
GGAACTCCAGAGTATTTGGCTCCAGAAATAATTCTCAGCAAGGGCTACAATAAGGCAGTG
GATTGGTGGGCATTAGGAGTGCTAATCTATGAAATGGCAGCTGGCTATCCCCCATTCTTT
GCAGACCAACCAATTCAGATTTATGAAAAGATTGTTTCTGGAAAGGTCCGATTCCCATCC
CACTTCAGTTCAGATCTCAAGGACCTTCTACGGAACCTGCTGCAGGTGGATTTGACCAAG
AGATTTGGAAATCTAAAGAATGGTGTCAGTGATATAAAAACTCACAAGTGGTTTGCCACG
ACAGATTGGATTGCTATTTACCAGAGGAAGGTTGAAGCTCCATTCATACCAAAGTTTAGA
GGCTCTGGAGATACCAGCAACTTTGATGACTATGAAGAAGAAGATATCCGTGTCTCTATA
ACAGAAAAATGTGCAAAAGAATTTGGTGAATTTTAA

Protein Properties

Number of Residues

351

Molecular Weight

40622.4

Theoretical pI

9.19

Pfam Domain Function

Pkinase (PF00069 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>cAMP-dependent protein kinase catalytic subunit beta
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF

External Links

GenBank ID Protein

189983

UniProtKB/Swiss-Prot ID

P22694

UniProtKB/Swiss-Prot Entry Name

KAPCB_HUMAN

PDB IDs