Cannabis Compound Database: Showing Protein Sodium/potassium-transporting ATPase subunit alpha-4 (CDBP02268)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP02268

Secondary Accession Numbers

Not Available

Name

Sodium/potassium-transporting ATPase subunit alpha-4

Description

Not Available

Synonyms

Na(+)/K(+) ATPase alpha-4 subunit
Sodium pump subunit alpha-4

Gene Name

ATP1A4

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

GO Classification

Biological Process
ATP biosynthetic process
ATP hydrolysis coupled proton transport
regulation of cellular pH
sperm motility
Cellular Component
sodium:potassium-exchanging ATPase complex
Component
intrinsic to membrane
integral to membrane
membrane
cell part
membrane part
Function
transporter activity
atpase activity, coupled to transmembrane movement of ions
binding
atpase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
catalytic activity
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
hydrolase activity
hydrolase activity, acting on acid anhydrides
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
Molecular Function
metal ion binding
ATP binding
sodium:potassium-exchanging ATPase activity
Process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
establishment of localization
transport
monovalent inorganic cation transport
ion transport
atp biosynthetic process
purine nucleotide metabolic process
cation transport
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Cellular Location

Membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
Cardiac muscle contraction	Not Available
Insulin secretion	Not Available
Aldosterone-regulated sodium reabsorption	Not Available
Endocrine and other factor-regulated calcium reabsorption	Not Available
Proximal tubule bicarbonate reclamation	Not Available

Gene Properties

Chromosome Location

Locus

1q23.2

SNPs

ATP1A4

Gene Sequence

>3090 bp
ATGGGGCTTTGGGGGAAGAAAGGGACAGTGGCTCCCCATGACCAGAGTCCAAGACGAAGA
CCTAAAAAAGGGCTTATCAAGAAAAAAATGGTGAAGAGGGAAAAACAGAAGCGCAATATG
GAGGAACTGAAGAAGGAAGTGGTCATGGATGATCACAAATTAACCTTGGAAGAGCTGAGC
ACCAAGTACTCCGTGGACCTGACAAAGGGCCATAGCCACCAAAGGGCAAAGGAAATCCTG
ACTCGAGGTGGACCCAATACTGTTACCCCACCCCCCACCACTCCAGAATGGGTCAAATTC
TGTAAGCAACTGTTCGGAGGCTTCTCCCTCCTACTATGGACTGGGGCCATTCTCTGCTTT
GTGGCCTACAGCATCCAGATATATTTCAATGAGGAGCCTACCAAAGACAACCTCTACCTG
AGCATCGTACTGTCCGTCGTGGTCATCGTCACTGGCTGCTTCTCCTATTATCAGGAGGCC
AAGAGCTCCAAGATCATGGAGTCTTTTAAGAACATGGTGCCTCAGCAAGCTCTGGTAATT
CGAGGAGGAGAGAAGATGCAAATTAATGTACAAGAGGTGGTGTTGGGAGACCTGGTGGAA
ATCAAGGGTGGAGACCGAGTCCCTGCTGACCTCCGGCTTATCTCTGCACAAGGATGTAAG
GTGGACAACTCATCCTTGACTGGGGAGTCAGAACCCCAGAGCCGCTCCCCTGACTTCACC
CATGAGAACCCTCTGGAGACCCGAAACATCTGCTTCTTTTCCACCAACTGTGTGGAAGGA
ACCGCCCGGGGTATTGTGATTGCTACGGGAGACTCCACAGTGATGGGCAGAATTGCCTCC
CTGACGTCAGGCCTGGCGGTTGGCCAGACACCTATCGCTGCTGAGATCGAACACTTCATC
CATCTGATCACTGTGGTGGCCGTCTTCCTTGGTGTCACTTTTTTTGCGCTCTCACTTCTC
TTGGGCTATGGTTGGCTGGAGGCTATCATTTTTCTCATTGGCATCATTGTGGCCAATGTG
CCTGAGGGGCTGTTGGCCACAGTCACTGTGTGCCTGACCCTCACAGCCAAGCGCATGGCG
CGGAAGAACTGCCTGGTGAAGAACCTGGAGGCGGTGGAGACGCTGGGCTCCACGTCCACC
ATCTGCTCAGACAAGACGGGCACCCTCACCCAGAACCGCATGACCGTCGCCCACATGTGG
TTTGATATGACCGTGTATGAGGCCGACACCACTGAAGAACAGACTGGAAAAACATTTACC
AAGAGCTCTGATACCTGGTTTATGCTGGCCCGAATCGCTGGCCTCTGCAACCGGGCTGAC
TTTAAGGCTAATCAGGAGATCCTGCCCATTGCTAAGAGGGCCACAACAGGTGATGCTTCC
GAGTCAGCCCTCCTCAAGTTCATCGAGCAGTCTTACAGCTCTGTGGCGGAGATGAGAGAG
AAAAACCCCAAGGTGGCAGAGATTCCCTTTAATTCTACCAACAAGTACCAGATGTCCATC
CACCTTCGGGAGGACAGCTCCCAGACCCACGTACTGATGATGAAGGGTGCTCCGGAGAGG
ATCTTGGAGTTTTGTTCTACCTTTCTTCTGAATGGGCAGGAGTACTCAATGAACGATGAA
ATGAAGGAAGCCTTCCAAAATGCCTACTTAGAACTGGGAGGTCTGGGGGAACGTGTGCTA
GGCTTCTGCTTCTTGAATCTGCCTAGCAGCTTCTCCAAGGGATTCCCATTTAATACAGAT
GAAATAAATTTCCCCATGGACAACCTTTGTTTTGTGGGCCTCATATCCATGATTGACCCT
CCCCGAGCTGCAGTGCCTGATGCTGTGAGCAAGTGTCGCAGTGCAGGAATTAAGGTGATC
ATGGTAACAGGAGATCATCCCATTACAGCTAAGGCCATTGCCAAGGGTGTGGGCATCATC
TCAGAAGGCACTGAGACGGCAGAGGAAGTCGCTGCCCGGCTTAAGATCCCTATCAGCAAG
GTCGATGCCAGTGCTGCCAAAGCCATTGTGGTGCATGGTGCAGAACTGAAGGACATACAG
TCCAAGCAGCTTGATCAGATCCTCCAGAACCACCCTGAGATCGTGTTTGCTCGGACCTCC
CCTCAGCAGAAGCTCATCATTGTCGAGGGATGTCAGAGGCTGGGAGCCGTTGTGGCCGTG
ACAGGTGACGGGGTGAACGACTCCCCTGCGCTGAAGAAGGCTGACATTGGCATTGCCATG
GGCATCTCTGGCTCTGACGTCTCTAAGCAGGCAGCCGACATGATCCTGCTGGATGACAAC
TTTGCCTCCATCGTCACGGGGGTGGAGGAGGGCCGCCTGATCTTTGACAACCTGAAGAAA
TCCATCATGTACACCCTGACCAGCAACATCCCCGAGATCACGCCCTTCCTGATGTTCATC
ATCCTCGGTATACCCCTGCCTCTGGGAACCATAACCATCCTCTGCATTGATCTCGGCACT
GACATGGTCCCTGCCATCTCCTTGGCTTATGAGTCAGCTGAAAGCGACATCATGAAGAGG
CTTCCAAGGAACCCAAAGACGGATAATCTGGTGAACCACCGTCTCATTGGCATGGCCTAT
GGACAGATTGGGATGATCCAGGCTCTGGCTGGATTCTTTACCTACTTTGTAATCCTGGCT
GAGAATGGTTTTAGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATAC
TTGAATGACCTGGAGGACAGCTACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTG
GAGTTCACATGCCAAACGGCCTTTTTTGTCACCATCGTGGTTGTGCAGTGGGCGGATCTC
ATCATCTCCAAGACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTA
ATATTTGGGATCCTGGAGGAGACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATG
GACGTGGCCCTGCGAATGTACCCACTCAAGATAACCTGGTGGCTCTGTGCCATTCCCTAC
AGTATTCTCATCTTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGAT
GGCTGGGTGGAAAGGGAGACGTACTACTAA

Protein Properties

Number of Residues

1029

Molecular Weight

19608.69

Theoretical pI

5.97

Pfam Domain Function

Hydrolase (PF00702 )
E1-E2_ATPase (PF00122 )
Cation_ATPase_C (PF00689 )
Cation_ATPase_N (PF00690 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Sodium/potassium-transporting ATPase subunit alpha-4
MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELS
TKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCF
VAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVI
RGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFT
HENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFI
HLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMA
RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT
KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMRE
KNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDE
MKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDP
PRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK
VDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAV
TGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK
SIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR
LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKY
LNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVL
IFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPD
GWVERETYY

External Links

GenBank ID Protein

153946397

UniProtKB/Swiss-Prot ID

Q13733

UniProtKB/Swiss-Prot Entry Name

AT1A4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_144699.3

GeneCard ID