Identification
HMDB Protein ID CDBP03922
Secondary Accession Numbers Not Available
Name Dual specificity tyrosine-phosphorylation-regulated kinase 3
Description Not Available
Synonyms
  1. REDK
  2. Regulatory erythroid kinase
Gene Name DYRK3
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling
GO Classification
Function
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.1
SNPs DYRK3
Gene Sequence
>1767 bp
ATGGGAGGCACAGCTCGTGGGCCTGGGCGGAAGGATGCGGGGCCGCCTGGGGCCGGGCTC
CCGCCCCAGCAGCGGAGGTTGGGGGATGGTGTCTATGACACCTTCATGATGATAGATGAA
ACCAAATGTCCCCCCTGTTCAAATGTACTCTGCAATCCTTCTGAACCACCTCCACCCAGA
AGACTAAATATGACCACTGAGCAGTTTACAGGAGATCATACTCAGCACTTTTTGGATGGA
GGTGAGATGAAGGTAGAACAGCTGTTTCAAGAATTTGGCAACAGAAAATCCAATACTATT
CAGTCAGATGGCATCAGTGACTCTGAAAAATGCTCTCCTACTGTTTCTCAGGGTAAAAGT
TCAGATTGCTTGAATACAGTAAAATCCAACAGTTCATCCAAGGCACCCAAAGTGGTGCCT
CTGACTCCAGAACAAGCCCTGAAGCAATATAAACACCACCTCACTGCCTATGAGAAACTG
GAAATAATTAATTATCCAGAAATTTACTTTGTAGGTCCAAATGCCAAGAAAAGACATGGA
GTTATTGGTGGTCCCAATAATGGAGGGTATGATGATGCAGATGGGGCCTATATTCATGTA
CCTCGAGACCATCTAGCTTATCGATATGAGGTGCTGAAAATTATTGGCAAGGGGAGTTTT
GGGCAGGTGGCCAGGGTCTATGATCACAAACTTCGACAGTACGTGGCCCTAAAAATGGTG
CGCAATGAGAAGCGCTTTCATCGTCAAGCAGCTGAGGAGATCCGGATTTTGGAGCATCTT
AAGAAACAGGATAAAACTGGTAGTATGAACGTTATCCACATGCTGGAAAGTTTCACATTC
CGGAACCATGTTTGCATGGCCTTTGAATTGCTGAGCATAGACCTTTATGAGCTGATTAAA
AAAAATAAGTTTCAGGGTTTTAGCGTCCAGTTGGTACGCAAGTTTGCCCAGTCCATCTTG
CAATCTTTGGATGCCCTCCACAAAAATAAGATTATTCACTGCGATCTGAAGCCAGAAAAC
ATTCTCCTGAAACACCACGGGCGCAGTTCAACCAAGGTCATTGACTTTGGGTCCAGCTGT
TTCGAGTACCAGAAGCTCTACACATATATCCAGTCTCGGTTCTACAGAGCTCCAGAAATC
ATCTTAGGAAGCCGCTACAGCACACCAATTGACATATGGAGTTTTGGCTGCATCCTTGCA
GAACTTTTAACAGGACAGCCTCTCTTCCCTGGAGAGGATGAAGGAGACCAGTTGGCCTGC
ATGATGGAGCTTCTAGGGATGCCACCACCAAAACTTCTGGAGCAATCCAAACGTGCCAAG
TACTTTATTAATTCCAAGGGCATACCCCGCTACTGCTCTGTGACTACCCAGGCAGATGGG
AGGGTTGTGCTTGTGGGGGGTCGCTCACGTAGGGGTAAAAAGCGGGGTCCCCCAGGCAGC
AAAGACTGGGGGACAGCACTGAAAGGGTGTGATGACTACTTGTTTATAGAGTTCTTGAAA
AGGTGTCTTCACTGGGACCCCTCTGCCCGCTTGACCCCAGCTCAAGCATTAAGACACCCT
TGGATTAGCAAGTCTGTCCCCAGACCTCTCACCACCATAGACAAGGTGTCAGGGAAACGG
GTAGTTAATCCTGCAAGTGCTTTCCAGGGATTGGGTTCTAAGCTGCCTCCAGTTGTTGGA
ATAGCCAATAAGCTTAAAGCTAACTTAATGTCAGAAACCAATGGTAGTATACCCCTATGC
AGTGTATTGCCAAAACTGATTAGCTAG
Protein Properties
Number of Residues 588
Molecular Weight 65713.2
Theoretical pI 9.78
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Dual specificity tyrosine-phosphorylation-regulated kinase 3
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
GenBank ID Protein 10441415
UniProtKB/Swiss-Prot ID O43781
UniProtKB/Swiss-Prot Entry Name DYRK3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF186773
GeneCard ID DYRK3
GenAtlas ID DYRK3
HGNC ID HGNC:3094
References
General References Not Available