Identification |
HMDB Protein ID
| CDBP03922 |
Secondary Accession Numbers
| Not Available |
Name
| Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
Description
| Not Available |
Synonyms
|
- REDK
- Regulatory erythroid kinase
|
Gene Name
| DYRK3 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase activity |
Specific Function
| Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling |
GO Classification
|
Function |
protein kinase activity |
protein serine/threonine kinase activity |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
Process |
phosphorus metabolic process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
|
Cellular Location
|
- Nucleus
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1q32.1 |
SNPs
| DYRK3 |
Gene Sequence
|
>1767 bp
ATGGGAGGCACAGCTCGTGGGCCTGGGCGGAAGGATGCGGGGCCGCCTGGGGCCGGGCTC
CCGCCCCAGCAGCGGAGGTTGGGGGATGGTGTCTATGACACCTTCATGATGATAGATGAA
ACCAAATGTCCCCCCTGTTCAAATGTACTCTGCAATCCTTCTGAACCACCTCCACCCAGA
AGACTAAATATGACCACTGAGCAGTTTACAGGAGATCATACTCAGCACTTTTTGGATGGA
GGTGAGATGAAGGTAGAACAGCTGTTTCAAGAATTTGGCAACAGAAAATCCAATACTATT
CAGTCAGATGGCATCAGTGACTCTGAAAAATGCTCTCCTACTGTTTCTCAGGGTAAAAGT
TCAGATTGCTTGAATACAGTAAAATCCAACAGTTCATCCAAGGCACCCAAAGTGGTGCCT
CTGACTCCAGAACAAGCCCTGAAGCAATATAAACACCACCTCACTGCCTATGAGAAACTG
GAAATAATTAATTATCCAGAAATTTACTTTGTAGGTCCAAATGCCAAGAAAAGACATGGA
GTTATTGGTGGTCCCAATAATGGAGGGTATGATGATGCAGATGGGGCCTATATTCATGTA
CCTCGAGACCATCTAGCTTATCGATATGAGGTGCTGAAAATTATTGGCAAGGGGAGTTTT
GGGCAGGTGGCCAGGGTCTATGATCACAAACTTCGACAGTACGTGGCCCTAAAAATGGTG
CGCAATGAGAAGCGCTTTCATCGTCAAGCAGCTGAGGAGATCCGGATTTTGGAGCATCTT
AAGAAACAGGATAAAACTGGTAGTATGAACGTTATCCACATGCTGGAAAGTTTCACATTC
CGGAACCATGTTTGCATGGCCTTTGAATTGCTGAGCATAGACCTTTATGAGCTGATTAAA
AAAAATAAGTTTCAGGGTTTTAGCGTCCAGTTGGTACGCAAGTTTGCCCAGTCCATCTTG
CAATCTTTGGATGCCCTCCACAAAAATAAGATTATTCACTGCGATCTGAAGCCAGAAAAC
ATTCTCCTGAAACACCACGGGCGCAGTTCAACCAAGGTCATTGACTTTGGGTCCAGCTGT
TTCGAGTACCAGAAGCTCTACACATATATCCAGTCTCGGTTCTACAGAGCTCCAGAAATC
ATCTTAGGAAGCCGCTACAGCACACCAATTGACATATGGAGTTTTGGCTGCATCCTTGCA
GAACTTTTAACAGGACAGCCTCTCTTCCCTGGAGAGGATGAAGGAGACCAGTTGGCCTGC
ATGATGGAGCTTCTAGGGATGCCACCACCAAAACTTCTGGAGCAATCCAAACGTGCCAAG
TACTTTATTAATTCCAAGGGCATACCCCGCTACTGCTCTGTGACTACCCAGGCAGATGGG
AGGGTTGTGCTTGTGGGGGGTCGCTCACGTAGGGGTAAAAAGCGGGGTCCCCCAGGCAGC
AAAGACTGGGGGACAGCACTGAAAGGGTGTGATGACTACTTGTTTATAGAGTTCTTGAAA
AGGTGTCTTCACTGGGACCCCTCTGCCCGCTTGACCCCAGCTCAAGCATTAAGACACCCT
TGGATTAGCAAGTCTGTCCCCAGACCTCTCACCACCATAGACAAGGTGTCAGGGAAACGG
GTAGTTAATCCTGCAAGTGCTTTCCAGGGATTGGGTTCTAAGCTGCCTCCAGTTGTTGGA
ATAGCCAATAAGCTTAAAGCTAACTTAATGTCAGAAACCAATGGTAGTATACCCCTATGC
AGTGTATTGCCAAAACTGATTAGCTAG
|
Protein Properties |
Number of Residues
| 588 |
Molecular Weight
| 65713.2 |
Theoretical pI
| 9.78 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Dual specificity tyrosine-phosphorylation-regulated kinase 3
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
|
External Links |
GenBank ID Protein
| 10441415 |
UniProtKB/Swiss-Prot ID
| O43781 |
UniProtKB/Swiss-Prot Entry Name
| DYRK3_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF186773 |
GeneCard ID
| DYRK3 |
GenAtlas ID
| DYRK3 |
HGNC ID
| HGNC:3094 |
References |
General References
| Not Available |