Identification
HMDB Protein ID CDBP01458
Secondary Accession Numbers Not Available
Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Description Not Available
Synonyms
  1. Mutated in multiple advanced cancers 1
  2. Phosphatase and tensin homolog
Gene Name PTEN
Protein Type Enzyme
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
GO Classification
Biological Process
forebrain morphogenesis
endothelial cell migration
neuron-neuron synaptic transmission
locomotor rhythm
T cell receptor signaling pathway
positive regulation of excitatory postsynaptic membrane potential
long-term synaptic potentiation
angiogenesis
learning or memory
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of cell migration
male mating behavior
inositol phosphate dephosphorylation
negative regulation of organ growth
postsynaptic density assembly
phosphatidylinositol-mediated signaling
cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
phosphatidylinositol biosynthetic process
prepulse inhibition
multicellular organismal response to stress
negative regulation of axonogenesis
induction of apoptosis
apoptotic process
presynaptic membrane assembly
negative regulation of cell proliferation
negative regulation of cell size
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of cell proliferation
regulation of B cell apoptotic process
negative regulation of cell aging
negative regulation of cyclin-dependent protein kinase activity involved in G1/S
canonical Wnt receptor signaling pathway
negative regulation of apoptotic process
prostate gland growth
epidermal growth factor receptor signaling pathway
negative regulation of dendritic spine morphogenesis
cardiac muscle tissue development
negative regulation of protein kinase B signaling cascade
regulation of myeloid cell apoptotic process
rhythmic synaptic transmission
fibroblast growth factor receptor signaling pathway
negative regulation of epithelial cell proliferation
negative regulation of excitatory postsynaptic membrane potential
synapse maturation
nerve growth factor receptor signaling pathway
negative regulation of focal adhesion assembly
activation of mitotic anaphase-promoting complex activity
phosphatidylinositol dephosphorylation
negative regulation of myelination
central nervous system myelin maintenance
central nervous system neuron axonogenesis
maternal behavior
protein stabilization
dendritic spine morphogenesis
protein kinase B signaling cascade
negative regulation of phosphatidylinositol 3-kinase cascade
dentate gyrus development
heart development
negative regulation of ribosome biogenesis
cell migration
social behavior
negative regulation of synaptic vesicle clustering
Cellular Component
PML body
neuron projection
cytosol
myelin sheath adaxonal region
Schmidt-Lanterman incisure
nucleus
internal side of plasma membrane
Function
phosphatidylinositol bisphosphate phosphatase activity
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
protein domain specific binding
phosphoprotein phosphatase activity
pdz domain binding
protein tyrosine phosphatase activity
phosphatidylinositol trisphosphate phosphatase activity
ion binding
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
cation binding
protein tyrosine/serine/threonine phosphatase activity
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
magnesium ion binding
protein binding
inositol or phosphatidylinositol phosphatase activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
protein serine/threonine phosphatase activity
magnesium ion binding
phosphatidylinositol-3-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
lipid binding
protein tyrosine phosphatase activity
Process
regulation of cellular process
phosphorus metabolic process
negative regulation of cell migration
negative regulation of signal transduction
phosphate metabolic process
negative regulation of cell proliferation
negative regulation of intracellular protein kinase cascade
dephosphorylation
regulation of cell communication
negative regulation of protein kinase b signaling cascade
protein amino acid dephosphorylation
regulation of signal transduction
polyol metabolic process
metabolic process
organophosphate metabolic process
regulation of cell adhesion
regulation of cell proliferation
phospholipid metabolic process
regulation of cell-substrate adhesion
posttranscriptional regulation of gene expression
inositol metabolic process
regulation of cell-matrix adhesion
biological regulation
glycerophospholipid metabolic process
negative regulation of cell-matrix adhesion
regulation of biological process
phosphoinositide metabolic process
negative regulation of focal adhesion assembly
regulation of metabolic process
phosphoinositide dephosphorylation
inositol phosphate dephosphorylation
regulation of macromolecule metabolic process
regulation of protein stability
regulation of gene expression
cellular metabolic process
regulation of locomotion
small molecule metabolic process
regulation of cell motility
alcohol metabolic process
regulation of cell migration
Cellular Location
  1. Nucleus
  2. Nucleus
  3. Cytoplasm
  4. PML body
Pathways
Gene Properties
Chromosome Location 10
Locus 10q23.3
SNPs PTEN
Gene Sequence
>1212 bp
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGA
TTCGACTTAGACTTGACCTATATTTATCCAAACATTATTGCTATGGGATTTCCTGCAGAA
AGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAG
CATAAAAACCATTACAAGATATACAATCTTTGTGCTGAAAGACATTATGACACCGCCAAA
TTTAATTGCAGAGTTGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTT
ATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCA
GCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTA
CATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACC
AGAGACAAAAAGGGAGTAACTATTCCCAGTCAGAGGCGCTATGTGTATTATTATAGCTAC
CTGTTAAAGAATCATCTGGATTATAGACCAGTGGCACTGTTGTTTCACAAGATGATGTTT
GAAACTATTCCAATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTCTGCCAGCTA
AAGGTGAAGATATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTAC
TTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCAAAGTAGAGTTCTTCCACAAA
CAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATA
CCAGGACCAGAGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATC
GATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGGAATATCTAGTACTTACTTTA
ACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAAT
TTTAAGGTGAAGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGC
AGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTATAGATATTCT
GACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATT
ACAAAAGTCTGA
Protein Properties
Number of Residues 403
Molecular Weight 47165.92
Theoretical pI 6.371
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P60484
UniProtKB/Swiss-Prot Entry Name PTEN_HUMAN
PDB IDs
GenBank Gene ID U96180
GeneCard ID PTEN
GenAtlas ID PTEN
HGNC ID HGNC:9588
References
General References Not Available