Identification
HMDB Protein ID CDBP04672
Secondary Accession Numbers Not Available
Name DNA-(apurinic or apyrimidinic site) lyase
Description Not Available
Synonyms
  1. AP endonuclease 1
  2. APEN
  3. APEX nuclease
  4. Apurinic-apyrimidinic endonuclease 1
  5. Protein REF-1
Gene Name APEX1
Protein Type Enzyme
Biological Properties
General Function Involved in DNA binding
Specific Function Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin
GO Classification
Component
cell part
intracellular
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
nucleic acid binding
dna binding
nuclease activity
endonuclease activity
Process
macromolecule metabolic process
cellular macromolecule metabolic process
dna metabolic process
dna repair
metabolic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2
SNPs APEX1
Gene Sequence
>957 bp
ATGCCGAAGCGTGGGAAAAAGGGAGCGGTGGCGGAAGACGGGGATGAGCTCAGGACAGAG
CCAGAGGCCAAGAAGAGTAAGACGGCCGCAAAGAAAAATGACAAAGAGGCAGCAGGAGAG
GGCCCAGCCCTGTATGAGGACCCCCCAGATCAGAAAACCTCACCCAGTGGCAAACCTGCC
ACACTCAAGATCTGCTCTTGGAATGTGGATGGGCTTCGAGCCTGGATTAAGAAGAAAGGA
TTAGATTGGGTAAAGGAAGAAGCCCCAGATATACTGTGCCTTCAAGAGACCAAATGTTCA
GAGAACAAACTACCAGCTGAACTTCAGGAGCTGCCTGGACTCTCTCATCAATACTGGTCA
GCTCCTTCGGACAAGGAAGGGTACAGTGGCGTGGGCCTGCTTTCCCGCCAGTGCCCACTC
AAAGTTTCTTACGGCATAGGCGATGAGGAGCATGATCAGGAAGGCCGGGTGATTGTGGCT
GAATTTGACTCGTTTGTGCTGGTAACAGCATATGTACCTAATGCAGGCCGAGGTCTGGTA
CGACTGGAGTACCGGCAGCGCTGGGATGAAGCCTTTCGCAAGTTCCTGAAGGGCCTGGCT
TCCCGAAAGCCCCTTGTGCTGTGTGGAGACCTCAATGTGGCACATGAAGAAATTGACCTT
CGCAACCCGAAGGGGAACAAAAAGAATGCTGGCTTCACGCCACAAGAGGCCCAAGGCTTC
GGGGAATTACTGCAGGCTGTGCCACTGGCTGACAGCTTTAGGCACCTCTACCCCAACACA
CCCTATGCCTACACCTTTTGGACTTATATGATGAATGCTCGATCCAAGAATGTTGGTTGG
CGCCTTGATTACTTTTTGTTGTCCCACTCTCTGTTACCTGCATTGTGTGACAGCAAGATC
CGTTCCAAGGCCCTCGGCAGTGATCACTGTCCTATCACCCTATACCTAGCACTGTGA
Protein Properties
Number of Residues 318
Molecular Weight 35554.2
Theoretical pI 8.26
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>DNA-(apurinic or apyrimidinic site) lyase
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
GenBank ID Protein 32024
UniProtKB/Swiss-Prot ID P27695
UniProtKB/Swiss-Prot Entry Name APEX1_HUMAN
PDB IDs
GenBank Gene ID X59764
GeneCard ID APEX1
GenAtlas ID APEX1
HGNC ID HGNC:587
References
General References Not Available