| Identification |
|---|
| HMDB Protein ID
| CDBP00105 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nucleoside diphosphate kinase A |
| Description
| Not Available |
| Synonyms
|
- GAAD
- Granzyme A-activated DNase
- Metastasis inhibition factor nm23
- NDK A
- NDP kinase A
- Tumor metastatic process-associated protein
- nm23-H1
|
| Gene Name
| NME1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleoside diphosphate kinase activity |
| Specific Function
| Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
|
| GO Classification
|
| Biological Process |
| nucleobase-containing small molecule interconversion |
| positive regulation of DNA binding |
| nervous system development |
| CTP biosynthetic process |
| GTP biosynthetic process |
| UTP biosynthetic process |
| cell differentiation |
| regulation of apoptotic process |
| positive regulation of epithelial cell proliferation |
| negative regulation of cell proliferation |
| endocytosis |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| phosphotransferase activity, phosphate group as acceptor |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| nucleoside diphosphate kinase activity |
| binding |
| Molecular Function |
| magnesium ion binding |
| ATP binding |
| nucleoside diphosphate kinase activity |
| deoxyribonuclease activity |
| GTP binding |
| Process |
| pyrimidine ribonucleoside triphosphate biosynthetic process |
| utp biosynthetic process |
| purine nucleotide metabolic process |
| purine nucleotide biosynthetic process |
| purine nucleoside triphosphate biosynthetic process |
| purine ribonucleoside triphosphate biosynthetic process |
| gtp biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| ctp biosynthetic process |
| pyrimidine nucleotide metabolic process |
| pyrimidine nucleoside triphosphate biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Gemcitabine Action Pathway |    | Not Available | | Gemcitabine Metabolism Pathway |    | Not Available | | Tenofovir Metabolism Pathway |    | Not Available | | Lamivudine Metabolism Pathway |    | Not Available | | Adefovir Dipivoxil Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21.3 |
| SNPs
| NME1 |
| Gene Sequence
|
>459 bp
ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTT
GTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAATTC
ATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC
TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGG
CTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAG
CCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGAACATTATACATGGCAGT
GATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTGTGGTTTCACCCTGAGGAACTGGTA
GATTACACGAGCTGTGCTCAGAACTGGATCTATGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 152 |
| Molecular Weight
| 17148.635 |
| Theoretical pI
| 6.186 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nucleoside diphosphate kinase A
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPF
FAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
|
| External Links |
|---|
| GenBank ID Protein
| 4557797 |
| UniProtKB/Swiss-Prot ID
| P15531 |
| UniProtKB/Swiss-Prot Entry Name
| NDKA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_000269.2 |
| GeneCard ID
| NME1 |
| GenAtlas ID
| NME1 |
| HGNC ID
| HGNC:7849 |
| References |
|---|
| General References
| Not Available |