Showing Protein Nucleoside diphosphate kinase A (CDBP00105)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 14 compounds
Identification
HMDB Protein ID CDBP00105
Secondary Accession Numbers Not Available
Name Nucleoside diphosphate kinase A
Description Not Available
Synonyms
  1. GAAD
  2. Granzyme A-activated DNase
  3. Metastasis inhibition factor nm23
  4. NDK A
  5. NDP kinase A
  6. Tumor metastatic process-associated protein
  7. nm23-H1
Gene Name NME1
Protein Type Enzyme
Biological Properties
General Function Involved in nucleoside diphosphate kinase activity
Specific Function Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
GO Classification
Biological Process
nucleobase-containing small molecule interconversion
positive regulation of DNA binding
nervous system development
CTP biosynthetic process
GTP biosynthetic process
UTP biosynthetic process
cell differentiation
regulation of apoptotic process
positive regulation of epithelial cell proliferation
negative regulation of cell proliferation
endocytosis
Cellular Component
nucleus
cytosol
Function
nucleoside diphosphate kinase activity
binding
catalytic activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
GTP binding
magnesium ion binding
ATP binding
nucleoside diphosphate kinase activity
deoxyribonuclease activity
Process
nucleotide metabolic process
pyrimidine nucleotide metabolic process
ctp biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine ribonucleoside triphosphate biosynthetic process
utp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
gtp biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 17
Locus 17q21.3
SNPs NME1
Gene Sequence 
>459 bp
ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTT
GTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAATTC
ATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC
TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGG
CTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAG
CCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGAACATTATACATGGCAGT
GATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTGTGGTTTCACCCTGAGGAACTGGTA
GATTACACGAGCTGTGCTCAGAACTGGATCTATGAATGA
Protein Properties
Number of Residues 152
Molecular Weight 17148.635
Theoretical pI 6.186
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Nucleoside diphosphate kinase A
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPF
FAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
GenBank ID Protein 4557797
UniProtKB/Swiss-Prot ID P15531
UniProtKB/Swiss-Prot Entry Name NDKA_HUMAN
PDB IDs
GenBank Gene ID NM_000269.2
GeneCard ID NME1
GenAtlas ID NME1
HGNC ID HGNC:7849
References
General References Not Available