Identification
HMDB Protein ID CDBP04041
Secondary Accession Numbers Not Available
Name Ubiquitin-like domain-containing CTD phosphatase 1
Description Not Available
Synonyms
  1. Nuclear proteasome inhibitor UBLCP1
Gene Name UBLCP1
Protein Type Enzyme
Biological Properties
General Function Involved in phosphoprotein phosphatase activity
Specific Function Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
GO Classification
Cellular Component
nucleolus
Component
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
organelle
Function
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
phosphoprotein phosphatase activity
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location 5
Locus 5q33.3
SNPs UBLCP1
Gene Sequence
>957 bp
ATGGCTCTCCCTATCATTGTAAAATGGGGTGGACAGGAGTATTCAGTGACCACACTTTCA
GAAGATGATACTGTGCTCGATCTCAAACAGTTTCTCAAGACCCTTACAGGAGTTCTTCCA
GAACGCCAAAAGTTACTTGGACTCAAAGTTAAAGGCAAACCTGCAGAAAATGATGTTAAG
CTTGGAGCTCTCAAACTGAAACCAAATACTAAAATCATGATGATGGGAACTCGTGAGGAG
AGCTTGGGAGATGTCTTAGGTCCACCCCCTGACAATGATGATGTTGTTAATGACTTTGAT
ATTGAAGATGAAGTAGTTGAAGTAGAAAATAGGGAAGAAAACCTACTGAAAATTTCTCGC
AGAGTGAAAGAGTACAAAGTGGAAATTTTGAATCCTCCCAGGGAAGGGAAAAAGCTTTTG
GTGCTAGATGTTGATTATACATTATTTGACCACAGGTCTTGTGCAGAGACTGGGGTAGAA
TTAATGCGGCCATATCTTCATGAATTTCTAACATCTGCCTATGAAGATTATGACATTGTT
ATTTGGTCTGCAACAAATATGAAGTGGATTGAAGCTAAAATGAAAGAGCTGGGAGTGAGC
ACAAATGCAAATTATAAGATTACTTTCATGTTGGATAGTGCTGCTATGATAACAGTACAT
ACTCCAAGGAGAGGATTAATAGACGTAAAGCCTCTTGGTGTTATATGGGGAAAGTTTTCG
GAGTTTTACAGCAAGAAAAACACCATTATGTTTGATGACATAGGGAGAAATTTTCTAATG
AACCCACAGAATGGACTAAAGATAAGGCCTTTTATGAAAGCGCACCTAAATCGTGATAAA
GACAAAGAACTTTTAAAATTAACTCAGTACCTCAAGGAGATAGCAAAATTAGATGACTTT
TTGGATCTAAATCACAAATATTGGGAAAGATATCTCTCAAAGAAGCAAGGACAGTAG
Protein Properties
Number of Residues 318
Molecular Weight 36804.355
Theoretical pI 6.461
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-like domain-containing CTD phosphatase 1
MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQKLLGLKVKGKPAENDVK
LGALKLKPNTKIMMMGTREESLEDVLGPPPDNDDVVNDFDIEDEVVEVENREENLLKISR
RVKEYKVEILNPPREGKKLLVLDVDYTLFDHRSCAETGVELMRPYLHEFLTSAYEDYDIV
IWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIDVKPLGVIWGKFS
EFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELLKLTQYLKEIAKLDDF
LDLNHKYWERYLSKKQGQ
GenBank ID Protein 16553992
UniProtKB/Swiss-Prot ID Q8WVY7
UniProtKB/Swiss-Prot Entry Name UBCP1_HUMAN
PDB IDs
GenBank Gene ID AK057996
GeneCard ID UBLCP1
GenAtlas ID UBLCP1
HGNC ID HGNC:28110
References
General References Not Available