Identification |
HMDB Protein ID
| CDBP04040 |
Secondary Accession Numbers
| Not Available |
Name
| Tubulin--tyrosine ligase |
Description
| Not Available |
Synonyms
|
- TTL
|
Gene Name
| TTL |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin (By similarity).
|
GO Classification
|
Biological Process |
regulation of axon extension |
cellular protein modification process |
microtubule cytoskeleton organization |
Function |
catalytic activity |
ligase activity |
ligase activity, forming carbon-nitrogen bonds |
acid-amino acid ligase activity |
tubulin-tyrosine ligase activity |
Molecular Function |
tubulin-tyrosine ligase activity |
ATP binding |
Process |
physiological process |
metabolism |
macromolecule metabolism |
macromolecule modification |
protein modification process |
metabolic process |
macromolecule metabolic process |
biopolymer metabolism |
biopolymer modification |
protein modification |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 2 |
Locus
| 2q13 |
SNPs
| TTL |
Gene Sequence
|
>1134 bp
ATGTACACCTTCGTGGTACGCGATGAGAACAGCAGCGTCTACGCCGAGGTCTCCCGGCTG
CTCCTCGCCACCGGCCACTGGAAGAGGCTGCGGCGAGACAACCCCAGATTCAACCTGATG
CTGGGAGAGAGGAATCGGCTGCCCTTCGGGAGACTGGGTCACGAGCCCGGGCTGGTACAG
TTGGTGAATTACTACAGGGGTGCTGACAAACTGTGTCGCAAAGCTTCTTTAGTGAAGCTA
ATCAAGACAAGCCCTGAACTGGCTGAGTCCTGCACATGGTTCCCTGAATCTTATGTGATT
TATCCAACCAATCTCAAGACTCCAGTTGCTCCAGCACAGAATGGAATTCAGCCACCAATC
AGTAACTCAAGGACAGATGAAAGAGAATTCTTTCTCGCCTCTTATAACAGAAAGAAAGAG
GATGGAGAGGGCAACGTTTGGATTGCAAAGTCATCAGCCGGTGCCAAAGGTGAAGGCATT
CTCATCTCCTCAGAGGCTTCAGAGCTTCTCGATTTCATAGACAACCAGGGCCAAGTGCAC
GTGATCCAGAAATATCTTGAGCACCCTCTGCTGCTTGAGCCAGGTCATCGCAAGTTTGAC
ATCCGAAGCTGGGTCTTGGTGGATCATCAGTATAATATCTACCTCTATAGAGAGGGTGTG
CTTCGGACTGCTTCAGAACCATATCATGTTGATAATTTCCAAGACAAAACCTGCCATTTG
ACCAATCACTGCATTCAAAAAGAGTATTCAAAGAACTACGGGAAGTATGAAGAAGGAAAT
GAAATGTTCTTCAAGGAGTTCAATCAGTACCTAACAAGTGCTTTGAACATTACCCTAGAA
AGTAGTATCTTACTACAAATCAAACATATAATAAGGAACTGCCTCCTGAGCGTGGAGCCT
GCCATTAGCACCAAGCACCTCCCTTACCAGAGCTTCCAGCTCTTCGGCTTTGACTTCATG
GTCGATGAGGAGCTGAAGGTGTGGCTCATTGAGGTCAACGGTGCCCCTGCATGTGCTCAG
AAGCTCTATGCAGAACTGTGCCAAGGCATCGTGGACATAGCCATTTCCAGTGTCTTCCCA
CCCCCAGATGTGGAGCAACCTCAGACCCAGCCAGCTGCCTTCATCAAGCTGTGA
|
Protein Properties |
Number of Residues
| 377 |
Molecular Weight
| 43211.94 |
Theoretical pI
| 6.744 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Tubulin--tyrosine ligase
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
|
External Links |
GenBank ID Protein
| 40363527 |
UniProtKB/Swiss-Prot ID
| Q8NG68 |
UniProtKB/Swiss-Prot Entry Name
| TTL_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB071393 |
GeneCard ID
| TTL |
GenAtlas ID
| TTL |
HGNC ID
| HGNC:21586 |
References |
General References
| Not Available |