Identification
HMDB Protein ID CDBP04040
Secondary Accession Numbers Not Available
Name Tubulin--tyrosine ligase
Description Not Available
Synonyms
  1. TTL
Gene Name TTL
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin (By similarity).
GO Classification
Biological Process
regulation of axon extension
cellular protein modification process
microtubule cytoskeleton organization
Function
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
tubulin-tyrosine ligase activity
Molecular Function
tubulin-tyrosine ligase activity
ATP binding
Process
physiological process
metabolism
macromolecule metabolism
macromolecule modification
protein modification process
metabolic process
macromolecule metabolic process
biopolymer metabolism
biopolymer modification
protein modification
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 2
Locus 2q13
SNPs TTL
Gene Sequence
>1134 bp
ATGTACACCTTCGTGGTACGCGATGAGAACAGCAGCGTCTACGCCGAGGTCTCCCGGCTG
CTCCTCGCCACCGGCCACTGGAAGAGGCTGCGGCGAGACAACCCCAGATTCAACCTGATG
CTGGGAGAGAGGAATCGGCTGCCCTTCGGGAGACTGGGTCACGAGCCCGGGCTGGTACAG
TTGGTGAATTACTACAGGGGTGCTGACAAACTGTGTCGCAAAGCTTCTTTAGTGAAGCTA
ATCAAGACAAGCCCTGAACTGGCTGAGTCCTGCACATGGTTCCCTGAATCTTATGTGATT
TATCCAACCAATCTCAAGACTCCAGTTGCTCCAGCACAGAATGGAATTCAGCCACCAATC
AGTAACTCAAGGACAGATGAAAGAGAATTCTTTCTCGCCTCTTATAACAGAAAGAAAGAG
GATGGAGAGGGCAACGTTTGGATTGCAAAGTCATCAGCCGGTGCCAAAGGTGAAGGCATT
CTCATCTCCTCAGAGGCTTCAGAGCTTCTCGATTTCATAGACAACCAGGGCCAAGTGCAC
GTGATCCAGAAATATCTTGAGCACCCTCTGCTGCTTGAGCCAGGTCATCGCAAGTTTGAC
ATCCGAAGCTGGGTCTTGGTGGATCATCAGTATAATATCTACCTCTATAGAGAGGGTGTG
CTTCGGACTGCTTCAGAACCATATCATGTTGATAATTTCCAAGACAAAACCTGCCATTTG
ACCAATCACTGCATTCAAAAAGAGTATTCAAAGAACTACGGGAAGTATGAAGAAGGAAAT
GAAATGTTCTTCAAGGAGTTCAATCAGTACCTAACAAGTGCTTTGAACATTACCCTAGAA
AGTAGTATCTTACTACAAATCAAACATATAATAAGGAACTGCCTCCTGAGCGTGGAGCCT
GCCATTAGCACCAAGCACCTCCCTTACCAGAGCTTCCAGCTCTTCGGCTTTGACTTCATG
GTCGATGAGGAGCTGAAGGTGTGGCTCATTGAGGTCAACGGTGCCCCTGCATGTGCTCAG
AAGCTCTATGCAGAACTGTGCCAAGGCATCGTGGACATAGCCATTTCCAGTGTCTTCCCA
CCCCCAGATGTGGAGCAACCTCAGACCCAGCCAGCTGCCTTCATCAAGCTGTGA
Protein Properties
Number of Residues 377
Molecular Weight 43211.94
Theoretical pI 6.744
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Tubulin--tyrosine ligase
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
GenBank ID Protein 40363527
UniProtKB/Swiss-Prot ID Q8NG68
UniProtKB/Swiss-Prot Entry Name TTL_HUMAN
PDB IDs Not Available
GenBank Gene ID AB071393
GeneCard ID TTL
GenAtlas ID TTL
HGNC ID HGNC:21586
References
General References Not Available