| Identification |
|---|
| HMDB Protein ID
| CDBP00992 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pyridoxal kinase |
| Description
| Not Available |
| Synonyms
|
- Pyridoxine kinase
|
| Gene Name
| PDXK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in pyridoxal kinase activity |
| Specific Function
| Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
|
| GO Classification
|
| Biological Process |
| cell proliferation |
| pyridoxal 5'-phosphate salvage |
| pyridoxal phosphate biosynthetic process |
| vitamin B6 metabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| pyridoxal kinase activity |
| Molecular Function |
| ATP binding |
| pyridoxal phosphate binding |
| zinc ion binding |
| protein homodimerization activity |
| sodium ion binding |
| lithium ion binding |
| pyridoxal kinase activity |
| potassium ion binding |
| magnesium ion binding |
| Process |
| metabolic process |
| small molecule metabolic process |
| vitamin metabolic process |
| water-soluble vitamin metabolic process |
| vitamin b6 metabolic process |
| pyridoxine metabolic process |
| pyridoxine biosynthetic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Vitamin B6 Metabolism |    |  | | Hypophosphatasia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| 21q22.3 |
| SNPs
| PDXK |
| Gene Sequence
|
>939 bp
ATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGC
AACCGGGCGGCCACGTTCCCGCTGCAGGTTTTGGGATTTGAGATTGACGCGGTGAACTCT
GTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGAT
GAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTG
CTCACAGGTTATACGAGGGACAAGTCGTTCCTGGCCATGGTGGTGGACATTGTGCAGGAG
CTGAAGCAGCAGAACCCCAGGCTGGTGTACGTGTGTGATCCAGTCTTGGGTGACAAGTGG
GACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTG
GTGCCGCTTGCAGACATTATCACGCCCAACCAGTTTGAGGCCGAGTTACTGAGTGGCCGG
AAGATCCACAGCCAGGAGGAAGCCTTGCGGGTGATGGACATGCTGCACTCTATGGGCCCC
GACACCGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATT
GTGCTGGGGAGTCAGAGGAGGAGGAATCCCGCTGGCTCCGTGGTGATGGAACGCATCCGG
ATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGGCACTGGGGACCTGTTTGCTGCCATG
CTCCTGGCGTGGACACACAAGCACCCCAATAACCTCAAGGTGGCCTGTGAGAAGACCGTG
TCTACCTTGCACCACGTTCTGCAGAGGACCATCCAGTGTGCAAAAGCCCAGGCCGGGGAA
GGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCGGATGGTGCAGAGCAAAAGGGACATC
GAGGACCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 312 |
| Molecular Weight
| 35102.105 |
| Theoretical pI
| 6.128 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyridoxal kinase
MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSD
ELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKW
DGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGP
DTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAM
LLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDI
EDPEIVVQATVL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O00764 |
| UniProtKB/Swiss-Prot Entry Name
| PDXK_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U89606 |
| GeneCard ID
| PDXK |
| GenAtlas ID
| PDXK |
| HGNC ID
| HGNC:8819 |
| References |
|---|
| General References
| Not Available |