| Identification |
|---|
| HMDB Protein ID
| CDBP03939 |
| Secondary Accession Numbers
| Not Available |
| Name
| 2-hydroxyacyl-CoA lyase 1 |
| Description
| Not Available |
| Synonyms
|
- 2-HPCL
- 2-hydroxyphytanoyl-CoA lyase
- Phytanoyl-CoA 2-hydroxylase 2
|
| Gene Name
| HACL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
|
| GO Classification
|
| Biological Process |
| protein oligomerization |
| fatty acid alpha-oxidation |
| Cellular Component |
| peroxisomal matrix |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| magnesium ion binding |
| vitamin binding |
| thiamin pyrophosphate binding |
| Molecular Function |
| magnesium ion binding |
| carbon-carbon lyase activity |
| thiamine pyrophosphate binding |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidation of Branched Chain Fatty Acids |    | Not Available | | Phytanic Acid Peroxisomal Oxidation |    | Not Available | | Peroxisome | Not Available |  | | Refsum Disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p25.1 |
| SNPs
| HACL1 |
| Gene Sequence
|
>1737 bp
ATGCCGGACAGTAACTTCGCAGAGCGCAGCGAGGAGCAGGTGTCTGGTGCTAAAGTCATC
GCTCAGGCCCTGAAAACGCAAGATGTGGAGTACATATTTGGCATCGTAGGCATCCCAGTG
ACCGAAATCGCCATTGCTGCCCAGCAGCTAGGCATCAAGTACATCGGGATGAGGAATGAG
CAAGCGGCTTGTTATGCTGCCTCCGCGATTGGATATCTGACAAGCAGGCCAGGAGTCTGC
CTTGTTGTTTCTGGCCCAGGTCTCATCCATGCCTTGGGCGGTATGGCAAATGCAAACATG
AACTGCTGGCCCTTGCTTGTGATTGGTGGTTCCTCTGAAAGAAACCAAGAAACAATGGGA
GCTTTCCAGGAGTTTCCTCAGGTTGAAGCTTGTAGATTATATACCAAGTTCTCTGCCCGC
CCAAGCAGCATAGAAGCTATTCCTTTTGTTATTGAAAAGGCAGTGAGAAGCAGTATCTAT
GGTCGTCCAGGTGCTTGCTATGTTGACATACCAGCAGATTTTGTGAACCTTCAGGTGAAT
GTGAATTCTATAAAGTACATGGAACGCTGCATGTCACCTCCTATTAGCATGGCAGAAACC
TCTGCTGTGTGCACGGCGGCTTCTGTTATTAGGAATGCCAAACAACCCCTTCTTATCATC
GGGAAAGGTGCTGCTTACGCTCATGCAGAAGAGAGTATCAAGAAATTGGTGGAGCAATAT
AAACTGCCATTTTTGCCCACCCCTATGGGGAAGGGTGTTGTCCCTGACAACCATCCATAC
TGTGTAGGTGCAGCCAGATCCAGGGCTTTGCAATTTGCTGATGTAATTGTGTTATTTGGT
GCCAGACTAAATTGGATTTTACATTTTGGACTGCCTCCAAGATATCAGCCAGATGTGAAG
TTTATCCAGGTTGATATCTGTGCAGAAGAATTGGGGAATAATGTAAAGCCCGCTGTTACT
TTGCTAGGAAACATACATGCTGTCACTAAGCAGCTTTTAGAGGAACTTGATAAAACACCA
TGGCAGTATCCTCCAGAGAGCAAGTGGTGGAAAACTCTGAGAGAAAAAATGAAGAGCAAT
GAAGCTGCATCCAAGGAACTAGCTTCTAAAAAATCCCTGCCTATGAATTATTACACAGTA
TTCTACCATGTTCAAGAACAACTACCTAGAGACTGTTTCGTGGTAAGTGAAGGAGCAAAT
ACTATGGACATTGGACGGACTGTGCTTCAGAACTACCTTCCTCGTCACAGGCTTGATGCT
GGTACTTTCGGAACAATGGGAGTTGGTTTGGGATTTGCTATTGCAGCTGCCGTGGTGGCT
AAAGATAGAAGCCCTGGGCAATGGATCATCTGTGTGGAAGGAGACAGTGCATTTGGGTTT
TCTGGCATGGAGGTAGAAACCATCTGCAGGTACAACTTGCCAATCATACTGTTGGTAGTG
AATAACAATGGAATTTACCAAGGTTTTGATACAGATACTTGGAAAGAAATGTTAAAATTT
CAAGATGCTACTGCAGTGGTCCCTCCAATGTGTTTGCTGCCAAATTCACATTATGAGCAA
GTCATGACTGCATTTGGAGGCAAAGGGTATTTTGTACAAACACCAGAAGAACTCCAAAAA
TCCCTGAGGCAGAGCCTAGCAGACACAACTAAACCTTCTCTTATCAACATCATGATTGAG
CCACAAGCCACACGGAAGGCCCAGGATTTTCATTGGCTGACCCGCTCTAATATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 578 |
| Molecular Weight
| 63728.095 |
| Theoretical pI
| 7.354 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2-hydroxyacyl-CoA lyase 1
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNE
QAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANMNCWPLLVIGGSSERNQETMG
AFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVN
VNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQY
KLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVK
FIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSN
EAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDA
GTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVV
NNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQK
SLRQSLADTTKPSLINIMIEPQATRKAQDFHWLTRSNM
|
| External Links |
|---|
| GenBank ID Protein
| 93004078 |
| UniProtKB/Swiss-Prot ID
| Q9UJ83 |
| UniProtKB/Swiss-Prot Entry Name
| HACL1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012260.2 |
| GeneCard ID
| HACL1 |
| GenAtlas ID
| HACL1 |
| HGNC ID
| HGNC:17856 |
| References |
|---|
| General References
| Not Available |