Cannabis Compound Database: Showing Protein Transient receptor potential cation channel subfamily M member 7 (CDBP01409)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP01409

Secondary Accession Numbers

Not Available

Name

Transient receptor potential cation channel subfamily M member 7

Description

Not Available

Synonyms

Channel-kinase 1
LTrpC-7
LTrpC7
Long transient receptor potential channel 7

Gene Name

TRPM7

Protein Type

Receptor

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)

GO Classification

Component
membrane
cell part
Function
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
protein kinase activity
transporter activity
ion channel activity
protein serine/threonine kinase activity
binding
catalytic activity
Process
phosphate metabolic process
metabolic process
establishment of localization
transport
cellular metabolic process
protein amino acid phosphorylation
transmembrane transport
phosphorylation
ion transport
phosphorus metabolic process

Cellular Location

Membrane
Multi-pass membrane protein (Probable)

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

15q21

SNPs

TRPM7

Gene Sequence

>5598 bp
ATGTCCCAGAAATCCTGGATAGAAAGCACTTTGACCAAGAGGGAATGTGTATATATTATA
CCAAGTTCCAAGGACCCTCACAGATGCCTTCCAGGATGTCAAATTTGTCAGCAACTCGTC
AGGTGTTTTTGTGGTCGCTTGGTCAAGCAACATGCTTGTTTTACTGCAAGTCTTGCCATG
AAATACTCAGATGTGAAATTGGGTGACCATTTTAATCAGGCAATAGAAGAATGGTCTGTG
GAAAAGCATACAGAACAGAGCCCAACGGATGCTTATGGAGTCATAAATTTTCAAGGGGGT
TCTCATTCCTACAGAGCTAAGTATGTGAGGCTATCATATGACACCAAACCTGAAGTCATT
CTGCAACTTCTGCTTAAAGAATGGCAAATGGAGTTACCCAAACTTGTTATCTCTGTACAT
GGGGGCATGCAGAAATTTGAGCTTCACCCACGAATCAAGCAGTTGCTTGGAAAAGGTCTT
ATTAAAGCTGCAGTTACAACTGGAGCCTGGATTTTAACTGGAGGAGTAAACACAGGTGTG
GCAAAACATGTTGGAGATGCCCTCAAAGAACATGCTTCCAGATCATCTCGAAAGATTTGC
ACTATCGGAATAGCTCCATGGGGAGTGATTGAAAACAGAAATGATCTTGTTGGGAGAGAT
GTGGTTGCTCCTTATCAAACCTTATTGAACCCCCTGAGCAAATTGAATGTTTTGAATAAT
CTGCATTCCCATTTCATATTGGTGGATGATGGCACTGTTGGAAAGTATGGGGCGGAAGTC
AGACTGAGAAGAGAACTTGAAAAAACTATTAATCAGCAAAGAATTCATGCTAGGATTGGC
CAGGGTGTCCCTGTGGTGGCACTTATATTTGAGGGTGGGCCAAATGTTATCCTCACAGTT
CTTGAATACCTTCAGGAAAGCCCCCCTGTTCCAGTAGTTGTGTGTGAAGGAACAGGCAGA
GCTGCAGATCTGCTAGCGTATATTCATAAACAAACAGAAGAAGGAGGGAATCTTCCTGAT
GCAGCAGAGCCCGATATTATTTCCACTATCAAAAAAACATTTAACTTTGGCCAGAATGAA
GCACTTCATTTATTTCAAACACTGATGGAGTGCATGAAAAGAAAGGAGCTTATCACTGTT
TTCCATATTGGGTCAGATGAACATCAAGATATAGATGTAGCAATACTTACTGCACTGCTA
AAAGGTACTAATGCATCTGCATTTGACCAGCTTATCCTTACATTGGCATGGGATAGAGTT
GACATTGCCAAAAATCATGTATTTGTTTATGGACAGCAGTGGCTGGTTGGATCCTTGGAA
CAAGCTATGCTTGATGCTCTTGTAATGGATAGAGTTGCATTTGTAAAACTTCTTATTGAA
AATGGAGTAAGCATGCATAAATTCCTTACCATTCCGAGACTGGAAGAACTTTACAACACT
AAACAAGGTCCAACTAATCCAATGCTGTTTCATCTTGTTCGAGACGTCAAACAGGGAAAT
CTTCCTCCAGGATATAAGATCACTCTGATTGATATAGGACTTGTTATTGAATATCTCATG
GGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGTCTT
GGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAG
AGTCATGAATCTTTTGGCAATAGGGCAGATAAAAAGGAAAAAATGAGGCATAACCATTTC
ATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAGAAG
AAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTAT
CCACTTAATGAACTTTTAATTTGGGCTTGCCTTATGAAGAGGCAGGTCATGGCCCGTTTT
TTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTATCGT
TCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAA
CAGTATTCCAATGATTTTGGTCAGTTGGCCGTTGAATTATTAGAACAGTCCTTCAGACAA
GATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCAACC
TGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAA
ATGTTGTTATCTGATATGTGGATGGGAAGGCTGAATATGAGGAAAAATTCCTGGTACAAG
GTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAGGCT
GAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAA
AACAACTTTCAGAACATAACAGAAGAGATCCCCATGGAAGTGTTTAAAGAAGTACGGATT
TTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTTCCA
ATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACG
TTGGCATATTTAGGATTTCTGATGCTTTATACATTTGTGGTTCTTGTACAAATGGAACAG
TTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAGAAA
GTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTT
AGTGATTACTTCAACATCAGTGATACAATTGCCATAATTTCTTTCTTCATTGGATTTGGA
CTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTGGCT
GGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTA
GCTGTAAATCAACAGGCAGGACCTTATGTAATGATGATTGGAAAAATGGTGGCCAATATG
TTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAGGCA
ATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCA
TACTGGATGATTTTTGGTGAAGTTTATGCATACGAAATTGATGTGTGTGCAAATGATTCT
GTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTCTAC
CTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTAT
TTACAAGTGAAGGCAATTTCCAATATTGTATGGAAGTACCAGCGTTATCATTTTATTATG
GCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTTTCT
CTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTT
TTCTTAACAGAAGAAGATCAAAAGAAACTTCATGATTTTGAAGAGCAGTGTGTTGAAATG
TATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTCACT
TTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTAC
ATAAAAAGATCATTACAATCATTAGATTCTCAAATTGGCCATTTGCAAGATCTTTCAGCC
CTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAAGTT
CATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGAT
GATGGTCCTGTAAGACCTTCTGTATGGAAAAAGCATGGTGTTGTAAATACACTTAGCTCC
TCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATGAAA
GATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGA
AAAGAATTTAATTTTCCAGAGGCTGGTTCCTCTTCTGGTGCCTTATTCCCAAGTGCTGTT
TCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAATAAA
AATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAA
TTTTTTGTTAGTACACCATCTCAGCCAAGTTGCAAAAGCCACTTGGAAACTGGAACCAAA
GATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCATTT
GTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAA
ATACTATCCAATAACAATACTTCTGAAAACACTTTGAAACGAGTGAGTTCTCTTGCTGGA
TTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGCAGAAAAAATCAGT
AGAAGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGAT
TGGTTACAAGATAGACCATCAAACAGAGAAATGCCATCTGAAGAAGGAACATTAAATGGT
CTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAAAGA
AATAACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAG
CCTGTCACAGTGTATCGTTTGGAAGAGAGTTCACCCAACATACTAAATAACAGCATGTCT
TCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATGGGA
GGAGGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAA
TCAGGGCATCTTTATATTATCAAATCTTTTCTTCCAGAGGTGGTTAATACATGGTCAAGT
ATTTATAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGAGCA
GCACAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCA
AGGTTCCTTGAAGTTTTCCTGCTGTATTGCCATTCAGCAGGACAGTGGTTTGCTGTGGAA
GAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATTCCA
ACTAATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGA
GGGGAGTTACTGGTACTTGATTTGCAAGGTGTTGGTGAAAATTTGACTGACCCATCTGTG
ATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGAGAA
GATGCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAA
CTTCCAGATCTGAAGAGGAATGATTATACGCCTGATAAAATTATATTTCCTCAGGATGAG
CCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAATTCT
GTTCGTCTGATGTTATAA

Protein Properties

Number of Residues

1865

Molecular Weight

212695.4

Theoretical pI

7.95

Pfam Domain Function

Ion_trans (PF00520 )
Alpha_kinase (PF02816 )

Signals

["None"]

Transmembrane Regions

["756-776", "856-876", "919-939", "963-983", "996-1016", "1075-1095"]

Protein Sequence

>Transient receptor potential cation channel subfamily M member 7
MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM
KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI
LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV
AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN
LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV
LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE
ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV
DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT
KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL
GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK
KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR
SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST
CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA
EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP
ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK
VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA
GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA
ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY
LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS
LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT
FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV
HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK
DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK
NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF
VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS
RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER
NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG
GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA
AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP
TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE
DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS
VRLML

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q96QT4

UniProtKB/Swiss-Prot Entry Name

TRPM7_HUMAN

PDB IDs