Identification |
HMDB Protein ID
| CDBP02504 |
Secondary Accession Numbers
| Not Available |
Name
| Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 |
Description
| Not Available |
Synonyms
|
- Methenyltetrahydrofolate cyclohydrolase
- NAD-dependent methylenetetrahydrofolate dehydrogenase
- NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
- MTHFD2-like
|
Gene Name
| MTHFD2L |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Not Available |
GO Classification
|
Biological Process |
purine nucleotide biosynthetic process |
methionine biosynthetic process |
folic acid-containing compound biosynthetic process |
histidine biosynthetic process |
tetrahydrofolate interconversion |
one-carbon metabolic process |
Cellular Component |
mitochondrion |
mitochondrial inner membrane |
Function |
binding |
catalytic activity |
Molecular Function |
methenyltetrahydrofolate cyclohydrolase activity |
methylenetetrahydrofolate dehydrogenase (NADP+) activity |
nucleotide binding |
methylenetetrahydrofolate dehydrogenase (NAD+) activity |
Process |
metabolic process |
cellular aromatic compound metabolic process |
folic acid and derivative metabolic process |
cellular metabolic process |
folic acid and derivative biosynthetic process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | tetrahydrofolate interconversion | Not Available | Not Available | One carbon pool by folate | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q13.3 |
SNPs
| MTHFD2L |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 289 |
Molecular Weight
| 37315.11 |
Theoretical pI
| 9.33 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
MAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILK
PKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGR
LCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGG
DATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVT
GKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY
|
External Links |
GenBank ID Protein
| 222418558 |
UniProtKB/Swiss-Prot ID
| Q9H903 |
UniProtKB/Swiss-Prot Entry Name
| MTD2L_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| MTHFD2L |
GenAtlas ID
| MTHFD2L |
HGNC ID
| HGNC:31865 |
References |
General References
| Not Available |