Identification |
HMDB Protein ID
| CDBP03920 |
Secondary Accession Numbers
| Not Available |
Name
| m7GpppN-mRNA hydrolase |
Description
| Not Available |
Synonyms
|
- Nucleoside diphosphate-linked moiety X motif 20
- Nudix motif 20
- hDpc
- mRNA-decapping enzyme 2
|
Gene Name
| DCP2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in RNA binding |
Specific Function
| Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety.
|
GO Classification
|
Biological Process |
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay |
gene expression |
histone mRNA catabolic process |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Cellular Component |
cytoplasmic mRNA processing body |
RNA-induced silencing complex |
nucleus |
cytosol |
Function |
manganese ion binding |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
hydrolase activity |
transition metal ion binding |
nucleic acid binding |
rna binding |
Molecular Function |
RNA binding |
exoribonuclease activity, producing 5'-phosphomonoesters |
m7G(5')pppN diphosphatase activity |
manganese ion binding |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- P-body
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | RNA degradation | Not Available | |
|
Gene Properties |
Chromosome Location
| 5 |
Locus
| 5q22.2 |
SNPs
| DCP2 |
Gene Sequence
|
>1263 bp
ATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATCTCTGCAGCCGATTT
ATTTTGCATATTCCCAGCGAGGAAAGAGACAATGCAATCCGAGTGTGTTTTCAGATTGAA
CTTGCCCATTGGTTTTACTTGGATTTCTACATGCAGAACACACCAGGATTACCTCAGTGT
GGGATAAGAGACTTTGCTAAAGCTGTCTTCAGTCATTGTCCGTTTTTGCTGCCTCAAGGT
GAAGATGTGGAAAAAGTTTTGGATGAATGGAAGGAATATAAAATGGGAGTACCAACATAT
GGTGCAATTATTCTTGATGAGACACTTGAAAATGTACTACTAGTTCAGGGGTACCTAGCA
AAATCAGGCTGGGGATTTCCAAAAGGAAAAGTAAATAAAGAAGAAGCTCCTCATGATTGT
GCTGCTAGAGAGGTCTTTGAAGAAACTGGTTTTGATATCAAAGACTATATTTGTAAGGAT
GATTACATTGAACTTCGAATCAATGACCAGCTTGCTCGTTTGTACATCATTCCAGGAATT
CCAAAAGACACAAAATTTAACCCAAAAACTAGAAGAGAAATTCGGAACATTGAGTGGTTC
TCTATTGAGAAATTGCCTTGTCATAGAAATGATATGACCCCCAAATCCAAACTTGGTTTG
GCACCTAACAAATTTTTTATGGCCATTCCCTTTATCAGACCATTAAGGGACTGGCTTTCT
CGAAGATTTGGCGATTCCTCAGACAGTGACAATGGATTTTCCTCAACTGGTAGCACGCCG
GCTAAACCCACTGTGGAAAAATTGAGTCGAACCAAATTCCGCCACAGTCAGCAGTTATTT
CCTGACGGTTCTCCTGGTGACCAGTGGGTAAAGCACAGGCAACCACTGCAGCAAAAGCCA
TATAATAATCATTCTGAAATGTCTGACCTTTTAAAAGGAAAGAATCAAAGTATGAGGGGA
AATGGCAGAAAACAGTATCAAGATTCACCTAATCAAAAGAAAAGAACAAATGGGCTTCAG
CCAGCAAAGCAGCAGAATTCTTTGATGAAGTGTGAAAAGAAACTTCATCCACGGAAACTT
CAGGATAATTTTGAAACAGATGCTGTATATGACTTGCCTAGCTCCAGTGAAGACCAGTTG
CTAGAACATGCTGAGGGACAGCCCGTGGCATGTAATGGACATTGCAAGTTCCCCTTTTCA
TCCAGAGCCTTTTTGAGTTTCAAGTTTGACCATAATGCTATAATGAAAATCTTGGACCTT
TGA
|
Protein Properties |
Number of Residues
| 420 |
Molecular Weight
| 44408.25 |
Theoretical pI
| 6.936 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>mRNA-decapping enzyme 2
METKRVEIPGSVLDDFCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQC
GIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLA
KSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGI
PKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLS
RRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKP
YNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKL
QDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL
|
External Links |
GenBank ID Protein
| 31542498 |
UniProtKB/Swiss-Prot ID
| Q8IU60 |
UniProtKB/Swiss-Prot Entry Name
| DCP2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_152624.4 |
GeneCard ID
| DCP2 |
GenAtlas ID
| DCP2 |
HGNC ID
| HGNC:24452 |
References |
General References
| Not Available |