Identification |
HMDB Protein ID
| CDBP01326 |
Secondary Accession Numbers
| Not Available |
Name
| Mitogen-activated protein kinase kinase kinase kinase 5 |
Description
| Not Available |
Synonyms
|
- KHS
- Kinase homologous to SPS1/STE20
- MAPK/ERK kinase kinase kinase 5
- MEK kinase kinase 5
- MEKKK 5
|
Gene Name
| MAP4K5 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in small GTPase regulator activity |
Specific Function
| May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway |
GO Classification
|
Function |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
enzyme regulator activity |
protein kinase activity |
protein serine/threonine kinase activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
small gtpase regulator activity |
binding |
Process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
phosphorus metabolic process |
phosphate metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 14q11.2-q21 |
SNPs
| MAP4K5 |
Gene Sequence
|
>2541 bp
ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTAC
GAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTA
CACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCT
TTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACATTGTAACATCGTTGCCTAC
TTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGA
TCACTTCAAGATATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTA
TGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAAAGGCAAAATGCATAGAGAT
ATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGT
GTGGCTGCAAAAATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTAC
TGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGGCTACAACCAACTCTGTGAT
ATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGAT
CTCCACCCAATGAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTA
AAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGTCAAAATAGCACTAACCAAA
AACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCA
GGTCTCTCTAGAGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCAC
GCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCATGCAATCATTCGTCATACC
ATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGAC
AAATTACAATTTGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTG
TCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGTTGATGGTGCAAATACTGGC
AAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGT
TACCCTGAAGACAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGAT
TCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAGCCCAAGTTGTGGGCCTGTG
GCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACA
GAAGGATCAGCACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAA
CCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGATGGGAGCATGCTTTTCAAAA
GTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACA
AAAGATCAGTACATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAG
CTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTGTACTTGGCTGTATGTTATC
AATAATACTTTAATGTCATTATCAGAAGGAAAAACCTTTCAGCTCTACTCTCACAATCTT
ATAGCTTTGTTTGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGG
TTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAACAAAGATTCCTGATACAAAA
GGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGA
GCTTTACAGTCTGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTG
ATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGTTTTTGAAATGCTGGTGATA
CCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAG
GTAGTTCAGTTTGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGT
GCAGGCAGCCAGCAGTTAGATTCCATTCATGTAACACAGTTGGAGAGAGATACCGTTTTA
GTGTGTTTAGACAAATTTGTGAAAATTGTAAATCTACAAGGAAAATTAAAATCAAGTAAG
AAACTGGCCTCTGAGTTAAGTTTTGATTTTCGCATTGAATCTGTAGTATGCCTTCAAGAC
AGTGTGTTGGCTTTCTGGAAACATGGGATGCAGGGTAAAAGCTTCAAGTCAGATGAGGTT
ACCCAGGAGATTTCAGATGAAACAAGAGTTTTCCGCTTATTAGGATCAGACAGGGTTGTC
GTTTTGGAAAGTAGGCCAACAGAAAATCCTACTGCACACAGCAATCTCTACATCTTGGCT
GGACATGAAAATAGTTACTAA
|
Protein Properties |
Number of Residues
| 846 |
Molecular Weight
| 95039.0 |
Theoretical pI
| 7.68 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Mitogen-activated protein kinase kinase kinase kinase 5
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKNDKRDFPK
PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
GHENSY
|
External Links |
GenBank ID Protein
| 23273903 |
UniProtKB/Swiss-Prot ID
| Q9Y4K4 |
UniProtKB/Swiss-Prot Entry Name
| M4K5_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| BC036013 |
GeneCard ID
| MAP4K5 |
GenAtlas ID
| MAP4K5 |
HGNC ID
| HGNC:6867 |
References |
General References
| Not Available |