Identification |
HMDB Protein ID
| CDBP01359 |
Secondary Accession Numbers
| Not Available |
Name
| Ectonucleoside triphosphate diphosphohydrolase 2 |
Description
| Not Available |
Synonyms
|
- CD39 antigen-like 1
- Ecto-ATP diphosphohydrolase 2
- Ecto-ATPDase 2
- Ecto-ATPase 2
- NTPDase 2
|
Gene Name
| ENTPD2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in ATP binding |
Specific Function
| In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
|
GO Classification
|
Biological Process |
platelet activation |
G-protein coupled receptor signaling pathway |
purine ribonucleoside diphosphate catabolic process |
Cellular Component |
basal lamina |
integral to membrane |
Function |
catalytic activity |
hydrolase activity |
Molecular Function |
nucleoside-diphosphatase activity |
nucleoside-triphosphatase activity |
ATP binding |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| ENTPD2 |
Gene Sequence
|
>1488 bp
ATGGCCGGGAAGGTGCGGTCACTGCTGCCGCCGCTGCTGCTGGCCGCCGCGGGCCTCGCC
GGCCTCCTACTGCTGTGCGTCCCCACCCGCGACGTCCGGGAGCCGCCCGCCCTCAAGTAT
GGCATCGTCCTGGACGCTGGTTCTTCACACACGTCCATGTTTATCTACAAGTGGCCGGCA
GACAAGGAGAACGACACAGGCATTGTGGGCCAGCACAGCTCCTGTGATGTTCCAGGTGGG
GGCATCTCCAGCTATGCAGACAACCCTTCTGGGGCCAGCCAGAGTCTTGTTGGATGCCTC
GAACAGGCGCTTCAGGATGTGCCCAAAGAGAGACACGCGGGCACACCCCTCTACCTGGGA
GCCACAGCGGGTATGCGCCTGCTCAACCTGACCAATCCAGAGGCCTCGACCAGTGTGCTC
ATGGCAGTGACTCACACACTGACCCAGTACCCCTTTGACTTCCGGGGTGCACGCATCCTC
TCGGGCCAGGAAGAGGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTACGGCTGGGTGGGCCGGTGGTTCCGGCCACGGAAGGGGACACTGGGGGCCATG
GACCTGGGGGGTGCCTCTACCCAGATCACTTTTGAGACAACCAGTCCAGCTGAGGACAGA
GCCAGCGAGGTCCAGCTGCATCTCTACGGCCAGCACTACCGAGTCTACACCCACAGCTTC
CTCTGCTATGGCCGTGACCAGGTCCTCCAGAGGCTGCTGGCCAGCGCCCTCCAGACCCAC
GGCTTCCACCCCTGCTGGCCGAGGGGCTTTTCCACCCAAGTGCTGCTCGGGGATGTGTAC
CAGTCACCATGCACCATGGCCCAGCGGCCCCAGAACTTCAACAGCAGTGCCAGGGTCAGC
CTGTCAGGGAGCAGTGACCCCCACCTCTGCCGAGATCTGGTTTCTGGGCTCTTCAGCTTC
TCCTCCTGCCCCTTCTCCCGATGCTCTTTCAATGGGGTCTTCCAGCCCCCAGTGGCTGGG
AACTTTGTGGCCTTCTCTGCCTTCTTCTACACTGTGGACTTTTTGCGGACTTCGATGGGG
CTGCCCGTGGCCACCCTGCAGCAGCTGGAGGCAGCCGCAGTGAATGTCTGCAACCAGACC
TGGGCTCAGCTGCAAGCTCGGGTGCCAGGGCAACGGGCCCGCCTGGCCGACTACTGCGCC
GGGGCCATGTTCGTGCAGCAGCTGCTGAGTCGCGGCTACGGCTTCGACGAGCGCGCCTTC
GGCGGCGTGATCTTCCAGAAGAAGGCCGCGGACACTGCAGTGGGCTGGGCGCTCGGCTAC
ATGCTGAACCTGACCAACCTGATCCCCGCCGACCCGCCGGGGCTGCGCAAGGGCACAGAC
TTCAGCTCCTGGGTCGTCCTCCTGCTGCTCTTCGCCTCCGCGCTCCTGGCTGCGCTTGTC
CTGCTGCTGCGTCAGGTGCACTCCGCCAAGCTGCCAAGCACCATTTAG
|
Protein Properties |
Number of Residues
| 495 |
Molecular Weight
| Not Available |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Ectonucleoside triphosphate diphosphohydrolase 2
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPA
DKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLG
ATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENF
IKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSF
LCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVS
LSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMG
LPVATLQQLEAAAVNVCNQTWAQLQARVPGQRARLADYCAGAMFVQQLLSRGYGFDERAF
GGVIFQKKAADTAVGWALGYMLNLTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALV
LLLRQVHSAKLPSTI
|
External Links |
GenBank ID Protein
| 5114239 |
UniProtKB/Swiss-Prot ID
| Q9Y5L3 |
UniProtKB/Swiss-Prot Entry Name
| ENTP2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF144748 |
GeneCard ID
| ENTPD2 |
GenAtlas ID
| ENTPD2 |
HGNC ID
| HGNC:3364 |
References |
General References
| Not Available |