Identification
HMDB Protein ID CDBP03941
Secondary Accession Numbers Not Available
Name Integrin-linked kinase-associated serine/threonine phosphatase 2C
Description Not Available
Synonyms
  1. ILKAP
Gene Name ILKAP
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
GO Classification
Biological Process
negative regulation of cell cycle
regulation of S phase of mitotic cell cycle
protein dephosphorylation
Cellular Component
cytoplasm
Component
macromolecular complex
protein complex
protein serine/threonine phosphatase complex
Function
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein serine/threonine phosphatase activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 2
Locus 2q37.3
SNPs ILKAP
Gene Sequence
>1179 bp
ATGGACCTCTTCGGGGACCTGCCGGAGCCCGAGCGCTCGCCGCGCCCGGCTGCCGGGAAA
GAAGCTCAGAAAGGACCCCTGCTCTTTGATGACCTCCCTCCGGCCAGCAGTACTGACTCA
GGATCAGGGGGACCTTTGCTTTTTGATGATCTCCCACCCGCTAGCAGTGGCGATTCAGGT
TCTCTTGCCACATCAATATCCCAGATGGTAAAGACTGAAGGGAAAGGAGCAAAGAGAAAA
ACCTCCGAGGAAGAGAAGAATGGCAGTGAAGAGCTTGTGGAAAAGAAAGTTTGTAAAGCC
TCTTCGGTGATCTTTGGTCTGAAGGGCTATGTGGCTGAGCGGAAGGGTGAGAGGGAGGAG
ATGCAGGATGCCCACGTCATCCTGAACGACATCACCGAGGAGTGTAGGCCCCCATCGTCC
CTCATTACTCGGGTTTCATATTTTGCTGTTTTTGATGGACATGGAGGAATTCGAGCCTCA
AAATTTGCTGCACAGAATTTGCATCAAAACTTAATCAGAAAATTTCCTAAAGGAGATGTA
ATCAGTGTAGAGAAAACCGTGAAGAGATGCCTTTTGGACACTTTCAAGCATACTGATGAA
GAGTTCCTTAAACAAGCTTCCAGCCAGAAGCCTGCCTGGAAAGATGGGTCCACTGCCACG
TGTGTTCTGGCTGTAGACAACATTCTTTATATTGCCAACCTCGGAGATAGTCGGGCAATC
TTGTGTCGTTATAATGAGGAGAGTCAAAAACATGCAGCCTTAAGCCTCAGCAAAGAGCAT
AATCCAACTCAGTATGAAGAGCGGATGAGGATACAGAAGGCTGGAGGAAACGTCAGGGAT
GGGCGTGTTTTGGGCGTGCTAGAGGTGTCACGCTCCATTGGGGACGGGCAGTACAAGCGC
TGCGGTGTCACCTCTGTGCCCGACATCAGACGCTGCCAGCTGACCCCCAATGACAGGTTC
ATTTTGTTGGCCTGTGATGGGCTCTTCAAGGTCTTTACCCCAGAAGAAGCCGTGAACTTC
ATCTTGTCCTGTCTCGAGGATGAAAAGATCCAGACCCGGGAAGGGAAGTCCGCAGCCGAC
GCCCGCTACGAAGCAGCCTGCAACAGGCTGGCCAACAAGGCGGTGCAGCGGGGCTCGGCC
GACAACGTCACTGTGATGGTGGTGCGGATAGGGCACTGA
Protein Properties
Number of Residues 392
Molecular Weight 42906.105
Theoretical pI 7.094
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Integrin-linked kinase-associated serine/threonine phosphatase 2C
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG
SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE
MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV
ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR
CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD
ARYEAACNRLANKAVQRGSADNVTVMVVRIGH
GenBank ID Protein 62988949
UniProtKB/Swiss-Prot ID Q9H0C8
UniProtKB/Swiss-Prot Entry Name ILKAP_HUMAN
PDB IDs Not Available
GenBank Gene ID AC016757
GeneCard ID ILKAP
GenAtlas ID ILKAP
HGNC ID HGNC:15566
References
General References Not Available