Cannabis Compound Database: Showing Protein Integrin-linked kinase-associated serine/threonine phosphatase 2C (CDBP03941)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03941

Secondary Accession Numbers

Not Available

Name

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Description

Not Available

Synonyms

ILKAP

Gene Name

ILKAP

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

GO Classification

Biological Process
negative regulation of cell cycle
regulation of S phase of mitotic cell cycle
protein dephosphorylation
Cellular Component
cytoplasm
Component
macromolecular complex
protein complex
protein serine/threonine phosphatase complex
Function
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein serine/threonine phosphatase activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

2q37.3

SNPs

ILKAP

Gene Sequence

>1179 bp
ATGGACCTCTTCGGGGACCTGCCGGAGCCCGAGCGCTCGCCGCGCCCGGCTGCCGGGAAA
GAAGCTCAGAAAGGACCCCTGCTCTTTGATGACCTCCCTCCGGCCAGCAGTACTGACTCA
GGATCAGGGGGACCTTTGCTTTTTGATGATCTCCCACCCGCTAGCAGTGGCGATTCAGGT
TCTCTTGCCACATCAATATCCCAGATGGTAAAGACTGAAGGGAAAGGAGCAAAGAGAAAA
ACCTCCGAGGAAGAGAAGAATGGCAGTGAAGAGCTTGTGGAAAAGAAAGTTTGTAAAGCC
TCTTCGGTGATCTTTGGTCTGAAGGGCTATGTGGCTGAGCGGAAGGGTGAGAGGGAGGAG
ATGCAGGATGCCCACGTCATCCTGAACGACATCACCGAGGAGTGTAGGCCCCCATCGTCC
CTCATTACTCGGGTTTCATATTTTGCTGTTTTTGATGGACATGGAGGAATTCGAGCCTCA
AAATTTGCTGCACAGAATTTGCATCAAAACTTAATCAGAAAATTTCCTAAAGGAGATGTA
ATCAGTGTAGAGAAAACCGTGAAGAGATGCCTTTTGGACACTTTCAAGCATACTGATGAA
GAGTTCCTTAAACAAGCTTCCAGCCAGAAGCCTGCCTGGAAAGATGGGTCCACTGCCACG
TGTGTTCTGGCTGTAGACAACATTCTTTATATTGCCAACCTCGGAGATAGTCGGGCAATC
TTGTGTCGTTATAATGAGGAGAGTCAAAAACATGCAGCCTTAAGCCTCAGCAAAGAGCAT
AATCCAACTCAGTATGAAGAGCGGATGAGGATACAGAAGGCTGGAGGAAACGTCAGGGAT
GGGCGTGTTTTGGGCGTGCTAGAGGTGTCACGCTCCATTGGGGACGGGCAGTACAAGCGC
TGCGGTGTCACCTCTGTGCCCGACATCAGACGCTGCCAGCTGACCCCCAATGACAGGTTC
ATTTTGTTGGCCTGTGATGGGCTCTTCAAGGTCTTTACCCCAGAAGAAGCCGTGAACTTC
ATCTTGTCCTGTCTCGAGGATGAAAAGATCCAGACCCGGGAAGGGAAGTCCGCAGCCGAC
GCCCGCTACGAAGCAGCCTGCAACAGGCTGGCCAACAAGGCGGTGCAGCGGGGCTCGGCC
GACAACGTCACTGTGATGGTGGTGCGGATAGGGCACTGA

Protein Properties

Number of Residues

392

Molecular Weight

42906.105

Theoretical pI

7.094

Pfam Domain Function

PP2C (PF00481 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Integrin-linked kinase-associated serine/threonine phosphatase 2C
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG
SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE
MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV
ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR
CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD
ARYEAACNRLANKAVQRGSADNVTVMVVRIGH

External Links

GenBank ID Protein

62988949

UniProtKB/Swiss-Prot ID

Q9H0C8

UniProtKB/Swiss-Prot Entry Name

ILKAP_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AC016757

GeneCard ID