Identification
HMDB Protein ID CDBP03956
Secondary Accession Numbers Not Available
Name G protein-activated inward rectifier potassium channel 3
Description Not Available
Synonyms
  1. GIRK-3
  2. Inward rectifier K(+) channel Kir3.3
  3. Potassium channel, inwardly rectifying subfamily J member 9
Gene Name KCNJ9
Protein Type Transporter
Biological Properties
General Function Involved in inward rectifier potassium channel activity
Specific Function This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium
GO Classification
Component
membrane
cell part
Function
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
g-protein activated inward rectifier potassium channel activity
ion channel activity
inward rectifier potassium channel activity
Process
establishment of localization
transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q23.2
SNPs KCNJ9
Gene Sequence
>1182 bp
ATGGCGCAGGAGAACGCGGCCTTCTCGCCCGGGCAGGAGGAGCCGCCGCGGCGCCGCGGC
CGCCAGCGCTACGTGGAGAAGGATGGCCGGTGCAACGTGCAGCAGGGCAACGTGCGCGAG
ACATACCGCTACCTGACGGACCTGTTCACCACGCTGGTGGACCTGCAGTGGCGCCTCAGC
CTGTTGTTCTTCGTCCTGGCCTACGCGCTCACCTGGCTCTTCTTCGGCGCCATCTGGTGG
CTGATCGCCTACGGCCGCGGCGACCTGGAGCACCTGGAGGACACCGCGTGGACGCCGTGC
GTCAACAACCTCAACGGCTTCGTGGCCGCCTTCCTCTTCTCCATCGAGACCGAGACCACC
ATCGGCTACGGGCACCGCGTCATCACCGACCAGTGCCCCGAGGGCATCGTGCTGCTGCTG
CTGCAGGCCATCCTGGGCTCCATGGTGAACGCCTTCATGGTGGGCTGCATGTTCGTCAAG
ATCTCGCAGCCCAACAAGCGCGCAGCCACGCTCGTCTTCTCCTCGCACGCCGTGGTGTCG
CTGCGCGACGGGCGCCTCTGCCTCATGTTCCGCGTGGGCGACTTGCGCTCCTCACACATA
GTGGAGGCCTCCATCCGCGCCAAGCTCATCCGCTCGCGCCAGACGCTGGAGGGCGAGTTC
ATCCCGCTGCACCAGACCGACCTCAGCGTGGGCTTCGACACGGGAGACGACCGCCTCTTC
CTCGTCTCGCCGCTGGTTATCAGCCACGAGATCGACGCCGCCAGCCCCTTCTGGGAGGCG
TCGCGCCGTGCCCTCGAGAGGGACGACTTCGAGATCGTCGTTATCCTCGAGGGCATGGTG
GAAGCCACGGGAATGACATGCCAAGCTCGGAGCTCCTACCTGGTAGACGAGGTGCTGTGG
GGCCACCGCTTCACGTCAGTGCTGACTCTGGAGGACGGCTTCTACGAAGTGGACTATGCC
AGCTTTCACGAGACTTTTGAGGTGCCCACACCTTCGTGCAGTGCTCGAGAGCTGGCAGAG
GCTGCCGCCCGCCTTGATGCCCATCTCTACTGGTCCATCCCCAGCCGGCTGGATGAGAAG
GTGGAGGAGGAGGGGGTGGGGGAGGGGGCGGGTGGGGAAGCTGGGGCTGACAAGGAGCAG
AATGGCTGCCTGCCACCCCCAGAGAGTGAGTCCAAGGTGTGA
Protein Properties
Number of Residues 393
Molecular Weight 44019.4
Theoretical pI 4.59
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["58-82", "135-156"]
Protein Sequence
>G protein-activated inward rectifier potassium channel 3
MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS
LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT
IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS
LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF
LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW
GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK
VEEEGAGEGAGGEAGADKEQNGCLPPPESESKV
GenBank ID Protein 9581856
UniProtKB/Swiss-Prot ID Q92806
UniProtKB/Swiss-Prot Entry Name IRK9_HUMAN
PDB IDs Not Available
GenBank Gene ID AF193615
GeneCard ID KCNJ9
GenAtlas ID KCNJ9
HGNC ID HGNC:6270
References
General References Not Available