Cannabis Compound Database: Showing Protein Chloride channel protein ClC-Kb (CDBP03397)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03397

Secondary Accession Numbers

Not Available

Name

Chloride channel protein ClC-Kb

Description

Not Available

Synonyms

Chloride channel Kb
ClC-K2

Gene Name

CLCNKB

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms

GO Classification

Component
membrane
cell part
Function
voltage-gated chloride channel activity
anion channel activity
chloride channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
transmembrane transport
anion transport
inorganic anion transport
ion transport
establishment of localization
transport
chloride transport

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1p36

SNPs

CLCNKB

Gene Sequence

>2064 bp
ATGGAGGAGTTTGTGGGGCTGCGTGAAGGCTCCTCAGGGAACCCTGTGACTCTGCAGGAG
CTGTGGGGCCCCTGTCCCCTCATCCGCCGAGGCATCCGAGGTGGCCTGGAGTGGCTGAAG
CAGAAGCTCTTCCGCCTGGGCGAGGACTGGTACTTCCTGATGACCCTCGGGGTGCTCATG
GCCCTGGTCAGCTGTGCCATGGACTTGGCTGTTGAGAGTGTGGTCCGAGCGCACCAGTGG
CTGTACAGGGAGATTGGGGACAGCCACCTGCTCCGGTATCTCTCCTGGACTGTGTACCCT
GTGGCCCTCGTCTCTTTCTCTTCGGGCTTCTCTCAGAGCATCACACCCTCCTCTGGAGGT
TCTGGAATCCCGGAGGTGAAGACCATGTTGGCGGGTGTGGTCTTGGAGGACTACCTGGAT
ATCAAGAACTTTGGGGCCAAAGTGGTGGGCCTCTCCTGCACCCTGGCCTGTGGCAGCACC
CTCTTCCTCGGCAAAGTGGGCCCTTTCGTGCACCTGTCTGTGATGATGGCTGCCTACCTG
GGCCGTGTGCGCACCACGACCATCGGGGAGCCTGAGAACAAGAGCAAGCAAAACGAAATG
CTGGTGGCAGCGGCGGCAGTGGGCGTGGCCACAGTCTTTGGCGCTCCCTTCAGCGGCGTC
CTGTTCAGCATCGAGGTCATGTCTTCCCACTTCTCTGTCTGGGATTACTGGAGGGGCTTC
TTTGCGGCCACCTGCGGGGCCTTCATGTTCCGGCTCCTGGCGGTCTTCAACAGCGAGCAG
GAGACCATCACCTCCCTCTACAAGACCAGTTTCCGGGTGGACGTTCCCTTCGACCTGCCT
GAGATCTTCTTTTTTGTGGTGCTGGGGGGTCTCTGCGGCATCCTGGGCAGCGCTTACCTC
TTCTGTCAGCGAATCTTCTTTGGCTTCATCAGGAACAATAGGTTCAGCTCCAAACTGCTG
GCCACCAGCAAGCCTGTGTACTCCGCTCTGGCCACCTTGGTTCTCGCCTCCATCACCTAC
CCACCCAGCGCCGGCCGCTTCCTAGCTTCTCGGCTGTCCATGAAGCAGCATCTGGACTCG
CTGTTCGACAACCACTCCTGGGCGCTGATGACCCAGAACTCCAGCCCACCCTGGCCCGAG
GAGCTCGACCCCCAGCACCTGTGGTGGGAATGGTACCACCCGCGGTTCACCATCTTTGGG
ACCCTTGCCTTCTTCCTGGTTATGAAGTTCTGGATGCTGATTCTGGCCACCACCATCCCC
ATGCCTGCCGGGTACTTCATGCCCATCTTTGTCTATGGAGCTGCTATCGGGCGCCTCTTT
GGGGAGACTCTCTCTTTTATCTTCCCTGAGGGCATCGTGGCTGGAGGGATCACCAATCCC
ATCATGCCAGGGGGGTATGCTCTGGCAGGGGCTGCAGCCTTCTCAGGGGCTGTGACCCAC
ACCATCTCCACGGCGCTGCTGGCCTTCGAGGTGACCGGCCAGATAGTGCATGCACTGCCC
GTGCTGATGGCGGTGCTGGCAGCCAACGCCATTGCACAGAGCTGCCAGCCCTCCTTCTAT
GATGGCACCGTCATTGTCAAGAAGCTGCCATACCTGCCACGGATTCTGGGCCGCAACATC
GGTTCCCACCGCGTGAGGGTGGAGCACTTCATGAACCACAGCATCACCACACTGGCCAAG
GACACGCCACTGGAGGAGGTGGTCAAGGTTGTGACCTCCACAGACGTGGCCGAGTATCCC
TTGGTGGAGAGCACAGAGTCCCAGATCCTGGTGGGCATAGTGCGAAGGGCCCAGCTGGTG
CAGGCCCTGAAGGCTGAGCCTCCTTCCTGGGCTCCTGGACACCAGCAGTGTCTCCAGGAC
ATCTTGGCTGCAGGCTGCCCCACAGAACCAGTGACCCTGAAGCTGTCCCCAGAGACTTCC
CTGCATGAGGCACACAACCTCTTTGAGCTGTTGAACCTTCATTCCCTCTTTGTGACGTCG
CGGGGCAGAGCTGTGGGCTGCGTGTCCTGGGTGGAGATGAAGAAAGCAATTTCCAACCTG
ACAAATCCGCCAGCCCCAAAGTGA

Protein Properties

Number of Residues

687

Molecular Weight

75445.3

Theoretical pI

8.07

Pfam Domain Function

CBS (PF00571 )
Voltage_CLC (PF00654 )

Signals

["None"]

Transmembrane Regions

["51-71", "94-114", "161-181", "202-222", "236-256", "282-302", "325-345", "396-416", "417-437", "452-472", "486-506"]

Protein Sequence

>Chloride channel protein ClC-Kb
MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL
GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGF
FAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYL
FCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDS
LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP
MPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH
TISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNI
GSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLV
QALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTS
RGRAVGCVSWVEMKKAISNLTNPPAPK

External Links

GenBank ID Protein

521074

UniProtKB/Swiss-Prot ID

P51801

UniProtKB/Swiss-Prot Entry Name

CLCKB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Z30644

GeneCard ID