Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase/endoribonuclease IRE1 (CDBP03928)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03928

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase/endoribonuclease IRE1

Description

Not Available

Synonyms

Endoplasmic reticulum-to-nucleus signaling 1
Endoribonuclease
IRE1a
Inositol-requiring protein 1
Ire1-alpha
Serine/threonine-protein kinase
hIRE1p

Gene Name

ERN1

Protein Type

Enzyme

Biological Properties

General Function

Involved in endoribonuclease activity, producing 5'-phosphomonoesters

Specific Function

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis

GO Classification

Function
protein serine/threonine kinase activity
nuclease activity
endonuclease activity
hydrolase activity, acting on ester bonds
endoribonuclease activity
binding
catalytic activity
endoribonuclease activity, producing 5'-phosphomonoesters
hydrolase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
rna metabolic process
phosphorus metabolic process
phosphate metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
cellular metabolic process
protein amino acid phosphorylation
mrna processing
phosphorylation

Cellular Location

Endoplasmic reticulum membrane
Single-pass type I membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q24.2

SNPs

ERN1

Gene Sequence

>2934 bp
ATGCCGGCCCGGCGGCTGCTGCTGCTGCTGACGCTGCTGCTGCCCGGCCTCGGGATTTTT
GGAAGTACCAGCACAGTGACGCTTCCTGAAACCTTGTTGTTTGTGTCAACGCTGGATGGA
AGTTTGCATGCTGTCAGCAAGAGGACAGGCTCAATCAAATGGACTTTAAAAGAAGATCCA
GTCCTGCAGGTCCCAACACATGTGGAAGAGCCTGCCTTTCTCCCAGATCCTAATGATGGC
AGCCTGTATACGCTTGGAAGCAAGAATAATGAAGGCCTGACGAAACTTCCTTTTACCATC
CCAGAATTGGTGCAGGCATCCCCATGCCGAAGTTCAGATGGAATCCTCTACATGGGTAAA
AAGCAGGACATCTGGTATGTTATTGACCTCCTGACCGGAGAGAAGCAGCAGACTTTGTCA
TCGGCCTTTGCAGATAGTCTCTGCCCATCAACCTCTCTTCTGTATCTTGGGCGAACAGAA
TACACCATCACCATGTACGACACCAAAACCCGAGAGCTCCGGTGGAATGCCACCTACTTT
GACTATGCGGCCTCACTGCCTGAGGACGACGTGGACTACAAGATGTCCCACTTTGTGTCC
AATGGTGATGGGCTGGTGGTGACTGTGGACAGTGAATCTGGGGACGTCCTGTGGATCCAA
AACTACGCCTCCCCTGTGGTGGCCTTTTATGTCTGGCAGCGGGAGGGTCTGAGGAAGGTG
ATGCACATCAATGTCGCTGTGGAGACCCTGCGCTATCTGACCTTCATGTCTGGGGAGGTG
GGGCGCATCACAAAGTGGAAGTACCCGTTCCCCAAGGAGACAGAGGCCAAGAGCAAGCTG
ACGCCCACTCTGTATGTTGGGAAATACTCTACCAGCCTCTATGCCTCTCCCTCAATGGTA
CACGAGGGGGTTGCTGTCGTGCCCCGCGGCAGCACACTTCCTTTGCTGGAAGGGCCCCAG
ACTGATGGCGTCACCATTGGGGACAAGGGGGAGTGTGTGATCACGCCCAGCACGGACGTC
AAGTTTGATCCCGGACTCAAAAGCAAGAACAAGCTCAACTACTTGAGGAATTACTGGCTT
CTGATAGGACACCATGAAACCCCACTGTCTGCGTCTACCAAGATGCTGGAGAGATTTCCC
AACAATCTACCCAAACATCGGGAAAATGTGATTCCTGCTGATTCAGAGAAAAAGAGCTTT
GAGGAAGTTATCAACCTGGTTGACCAGACTTCAGAAAACGCACCTACCACCGTGTCTCGG
GATGTGGAGGAGAAGCCCGCCCATGCCCCTGCCCGGCCCGAGGCCCCCGTGGACTCCATG
CTTAAGGACATGGCTACCATCATCCTGAGCACCTTCCTGCTGATTGGCTGGGTGGCCTTC
ATCATCACCTATCCCCTGAGCATGCATCAGCAGCAGCAGCTCCAGCACCAGCAGTTCCAG
AAGGAACTGGAGAAGATCCAGCTCCTGCAGCAGCAGCAGCAGCAGCTGCCCTTCCACCCA
CCTGGAGACACGGCTCAGGACGGCGAGCTCCTGGACACGTCTGGCCCGTACTCAGAGAGC
TCGGGCACCAGCAGCCCCAGCACGTCCCCCAGGGCCTCCAACCACTCGCTCTGCTCCGGC
AGCTCTGCCTCCAAGGCTGGCAGCAGCCCCTCCCTGGAACAAGACGATGGAGATGAGGAA
ACCAGCGTGGTGATAGTTGGGAAAATTTCCTTCTGTCCCAAGGATGTCCTGGGCCATGGA
GCTGAGGGCACAATTGTGTACCGGGGCATGTTTGACAACCGCGACGTGGCCGTGAAGAGG
ATCCTCCCCGAGTGTTTTAGCTTCGCAGACCGTGAGGTCCAGCTGTTGCGAGAATCGGAT
GAGCACCCGAACGTGATCCGCTACTTCTGCACGGAGAAGGACCGGCAATTCCAGTACATT
GCCATCGAGCTGTGTGCAGCCACCCTGCAAGAGTATGTGGAGCAGAAGGACTTTGCGCAT
CTCGGCCTGGAGCCCATCACCTTGCTGCAGCAGACCACCTCGGGCCTGGCCCACCTCCAC
TCCCTCAACATCGTTCACAGAGACCTAAAGCCACACAACATCCTCATATCCATGCCCAAT
GCACACGGCAAGATCAAGGCCATGATCTCCGACTTTGGCCTCTGCAAGAAGCTGGCAGTG
GGCAGACACAGTTTCAGCCGCCGATCTGGGGTGCCTGGCACAGAAGGCTGGATCGCTCCA
GAGATGCTGAGCGAAGACTGTAAGGAGAACCCTACCTACACGGTGGACATCTTTTCTGCA
GGCTGCGTCTTTTACTACGTAATCTCTGAGGGCAGCCACCCTTTTGGCAAGTCCCTGCAG
CGGCAGGCCAACATCCTCCTGGGTGCCTGCAGCCTTGACTGCTTGCACCCAGAGAAGCAC
GAAGACGTCATTGCACGTGAATTGATAGAGAAGATGATTGCGATGGATCCTCAGAAACGC
CCCTCAGCGAAGCATGTGCTCAAACACCCGTTCTTCTGGAGCCTAGAGAAGCAGCTCCAG
TTCTTCCAGGACGTGAGCGACAGAATAGAAAAGGAATCCCTGGATGGCCCGATCGTGAAG
CAGTTAGAGAGAGGCGGGAGAGCCGTGGTGAAGATGGACTGGCGGGAGAACATCACTGTC
CCCCTCCAGACAGACCTGCGTAAATTCAGGACCTATAAAGGTGGTTCTGTCAGAGATCTC
CTCCGAGCCATGAGAAATAAGAAGCACCACTACCGGGAGCTGCCTGCAGAGGTGCGGGAG
ACGCTGGGGTCCCTCCCCGACGACTTCGTGTGCTACTTCACATCTCGCTTCCCCCACCTC
CTCGCACACACCTACCGGGCCATGGAGCTGTGCAGCCACGAGAGACTCTTCCAGCCCTAC
TACTTCCACGAGCCCCCAGAGCCCCAGCCCCCAGTGACTCCAGACGCCCTCTGA

Protein Properties

Number of Residues

977

Molecular Weight

109734.1

Theoretical pI

6.39

Pfam Domain Function

Pkinase (PF00069 )
Ribonuc_2-5A (PF06479 )

Signals

["1-18"]

Transmembrane Regions

["444-464"]

Protein Sequence

>Serine/threonine-protein kinase/endoribonuclease IRE1
MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
YFHEPPEPQPPVTPDAL

External Links

GenBank ID Protein

153946421

UniProtKB/Swiss-Prot ID

O75460

UniProtKB/Swiss-Prot Entry Name

ERN1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001433.3

GeneCard ID