| Identification |
|---|
| HMDB Protein ID
| CDBP02614 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glycerophosphodiester phosphodiesterase 1 |
| Description
| Not Available |
| Synonyms
|
- Membrane-interacting protein of RGS16
- RGS16-interacting membrane protein
|
| Gene Name
| GDE1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glycerophosphodiester phosphodiesterase activity |
| Specific Function
| Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
|
| GO Classification
|
| Biological Process |
| glycerol metabolic process |
| lipid metabolic process |
| Cellular Component |
| cytoplasm |
| integral to membrane |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphoric diester hydrolase activity |
| glycerophosphodiester phosphodiesterase activity |
| Molecular Function |
| metal ion binding |
| glycerophosphodiester phosphodiesterase activity |
| glycerophosphoinositol glycerophosphodiesterase activity |
| Process |
| metabolic process |
| primary metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| polyol metabolic process |
| alditol metabolic process |
| glycerol metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Membrane
- Multi- pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phospholipid Biosynthesis |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p12-p11.2 |
| SNPs
| GDE1 |
| Gene Sequence
|
>996 bp
ATGTGGCTGTGGGAGGACCAGGGCGGCCTCCTGGGCCCTTTCTCCTTCCTGCTGCTAGTG
CTGCTGCTGGTGACGCGGAGCCCGGTCAATGCCTGCCTCCTCACCGGCAGCCTCTTCGTT
CTACTGCGCGTCTTCAGCTTTGAGCCGGTGCCCTCTTGCAGGGCCCTGCAGGTGCTCAAG
CCCCGGGACCGCATTTCTGCCATCGCCCACCGTGGCGGCAGCCACGACGCGCCCGAGAAC
ACGCTGGCGGCCATTCGGCAGGCAGCTAAGAATGGAGCAACAGGCGTGGAGTTGGACATT
GAGTTTACTTCTGACGGGATTCCTGTCTTAATGCACGATAACACAGTAGATAGGACGACT
GATGGGACTGGGCGATTGTGTGATTTGACATTTGAACAAATTAGGAAGCTGAATCCTGCA
GCAAACCACAGACTCAGGAATGATTTCCCTGATGAAAAGATCCCTACCCTAAGGGAAGCT
GTTGCAGAGTGCCTAAACCATAACCTCACAATCTTCTTTGATGTCAAAGGCCATGCACAC
AAGGCTACTGAGGCTCTAAAGAAAATGTATATGGAATTTCCTCAACTGTATAATAATAGT
GTGGTCTGTTCTTTCTTGCCAGAAGTTATCTACAAGATGAGACAAACAGATCGGGATGTA
ATAACAGCATTAACTCACAGACCTTGGAGCCTAAGCCATACAGGAGATGGGAAACCACGC
TATGATACTTTCTGGAAACATTTTATATTTGTTATGATGGACATTTTGCTCGATTGGAGC
ATGCATAATATCTTGTGGTACCTGTGTGGAATTTCAGCTTTCCTCATGCAAAAGGATTTT
GTATCCCCGGCCTACTTGAAGAAGTGGTCAGCTAAAGGAATCCAGGTTGTTGGTTGGACT
GTTAATACCTTTGATGAAAAGAGTTACTACGAATCCCATCTTGGTTCCAGCTATATCACT
GACAGCATGGTAGAAGACTGCGAACCTCACTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 331 |
| Molecular Weight
| 37718.04 |
| Theoretical pI
| 6.706 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycerophosphodiester phosphodiesterase 1
MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLK
PRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTT
DGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHAH
KATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPR
YDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWT
VNTFDEKSYYESHLGSSYITDSMVEDCEPHF
|
| External Links |
|---|
| GenBank ID Protein
| 7637877 |
| UniProtKB/Swiss-Prot ID
| Q9NZC3 |
| UniProtKB/Swiss-Prot Entry Name
| GDE1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF212862 |
| GeneCard ID
| GDE1 |
| GenAtlas ID
| GDE1 |
| HGNC ID
| HGNC:29644 |
| References |
|---|
| General References
| Not Available |