Identification
HMDB Protein ID CDBP01016
Secondary Accession Numbers Not Available
Name Sphingosine kinase 1
Description Not Available
Synonyms
  1. SK 1
  2. SPK 1
Gene Name SPHK1
Protein Type Enzyme
Biological Properties
General Function Involved in diacylglycerol kinase activity
Specific Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
GO Classification
Biological Process
negative regulation of apoptotic process
blood vessel development
positive regulation of fibroblast proliferation
positive regulation of NF-kappaB transcription factor activity
positive regulation of smooth muscle contraction
positive regulation of mitotic cell cycle
sphingolipid biosynthetic process
positive regulation of NF-kappaB import into nucleus
positive regulation of protein ubiquitination
regulation of interleukin-1 beta production
inflammatory response
regulation of tumor necrosis factor-mediated signaling pathway
sphingoid catabolic process
'de novo' posttranslational protein folding
protein kinase C-activating G-protein coupled receptor signaling pathway
positive regulation of angiogenesis
phospholipid metabolic process
brain development
positive regulation of cell migration
positive regulation of cell growth
calcium-mediated signaling
sphingosine metabolic process
Cellular Component
cytosol
plasma membrane
nucleus
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
diacylglycerol kinase activity
Molecular Function
calmodulin binding
DNA binding
magnesium ion binding
D-erythro-sphingosine kinase activity
diacylglycerol kinase activity
sphinganine kinase activity
ATP binding
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
activation of protein kinase c activity by g-protein coupled receptor protein signaling pathway
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 17
Locus 17q25.2
SNPs SPHK1
Gene Sequence
>1155 bp
ATGGATCCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCCGCGTGCTGGTGCTG
CTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCC
CTTTTGGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCG
CGGGAGCTGGTGCGGTCGGAGGAGCTGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGA
GACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCTGACTGGGAGACCGCC
ATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTG
AACCATTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTA
TTGCTGTGCCGCCGGCTGCTGTCACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGG
CTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCTGATGTGGACCTAGAG
AGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACTTTCCTGCGTCTG
GCAGCCTTGCGCACTTACCGCGGCCGACTGGCTTACCTCCCTGTAGGAAGAGTGGGTTCC
AAGACACCTGCCTCCCCCGTTGTGGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCA
CTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAGGACTTTGTGCTAGTC
CTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGT
GCAGCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTG
CGCCTCTTCCTGGCCATGGAGAAGGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTA
TATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAAGGTATGTTTGCAGTG
GATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGG
ATGGTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCA
GAAGAGCCCTTATGA
Protein Properties
Number of Residues 384
Molecular Weight 42517.245
Theoretical pI 7.115
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Sphingosine kinase 1
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
GenBank ID Protein 9909361
UniProtKB/Swiss-Prot ID Q9NYA1
UniProtKB/Swiss-Prot Entry Name SPHK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF200328
GeneCard ID SPHK1
GenAtlas ID SPHK1
HGNC ID HGNC:11240
References
General References Not Available