Identification |
HMDB Protein ID
| CDBP01016 |
Secondary Accession Numbers
| Not Available |
Name
| Sphingosine kinase 1 |
Description
| Not Available |
Synonyms
|
- SK 1
- SPK 1
|
Gene Name
| SPHK1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in diacylglycerol kinase activity |
Specific Function
| Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
|
GO Classification
|
Biological Process |
sphingosine metabolic process |
calcium-mediated signaling |
blood vessel development |
negative regulation of apoptotic process |
positive regulation of NF-kappaB transcription factor activity |
positive regulation of fibroblast proliferation |
positive regulation of smooth muscle contraction |
positive regulation of mitotic cell cycle |
sphingolipid biosynthetic process |
positive regulation of NF-kappaB import into nucleus |
positive regulation of protein ubiquitination |
regulation of interleukin-1 beta production |
inflammatory response |
regulation of tumor necrosis factor-mediated signaling pathway |
sphingoid catabolic process |
'de novo' posttranslational protein folding |
protein kinase C-activating G-protein coupled receptor signaling pathway |
positive regulation of angiogenesis |
brain development |
phospholipid metabolic process |
positive regulation of cell growth |
positive regulation of cell migration |
Cellular Component |
cytosol |
plasma membrane |
nucleus |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
diacylglycerol kinase activity |
Molecular Function |
ATP binding |
calmodulin binding |
DNA binding |
magnesium ion binding |
D-erythro-sphingosine kinase activity |
diacylglycerol kinase activity |
sphinganine kinase activity |
Process |
signaling |
signaling pathway |
cell surface receptor linked signaling pathway |
g-protein coupled receptor protein signaling pathway |
activation of protein kinase c activity by g-protein coupled receptor protein signaling pathway |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Calcium signaling pathway | Not Available | | VEGF signaling pathway | Not Available | | Fc gamma R-mediated phagocytosis | Not Available | | Tuberculosis | Not Available | |
|
Gene Properties |
Chromosome Location
| 17 |
Locus
| 17q25.2 |
SNPs
| SPHK1 |
Gene Sequence
|
>1155 bp
ATGGATCCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCCGCGTGCTGGTGCTG
CTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCC
CTTTTGGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCG
CGGGAGCTGGTGCGGTCGGAGGAGCTGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGA
GACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCTGACTGGGAGACCGCC
ATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTG
AACCATTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTA
TTGCTGTGCCGCCGGCTGCTGTCACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGG
CTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCTGATGTGGACCTAGAG
AGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACTTTCCTGCGTCTG
GCAGCCTTGCGCACTTACCGCGGCCGACTGGCTTACCTCCCTGTAGGAAGAGTGGGTTCC
AAGACACCTGCCTCCCCCGTTGTGGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCA
CTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAGGACTTTGTGCTAGTC
CTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGT
GCAGCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTG
CGCCTCTTCCTGGCCATGGAGAAGGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTA
TATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAAGGTATGTTTGCAGTG
GATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGG
ATGGTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCA
GAAGAGCCCTTATGA
|
Protein Properties |
Number of Residues
| 384 |
Molecular Weight
| 42517.245 |
Theoretical pI
| 7.115 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Sphingosine kinase 1
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
|
External Links |
GenBank ID Protein
| 9909361 |
UniProtKB/Swiss-Prot ID
| Q9NYA1 |
UniProtKB/Swiss-Prot Entry Name
| SPHK1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF200328 |
GeneCard ID
| SPHK1 |
GenAtlas ID
| SPHK1 |
HGNC ID
| HGNC:11240 |
References |
General References
| Not Available |