| Identification |
|---|
| HMDB Protein ID
| CDBP01016 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sphingosine kinase 1 |
| Description
| Not Available |
| Synonyms
|
- SK 1
- SPK 1
|
| Gene Name
| SPHK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in diacylglycerol kinase activity |
| Specific Function
| Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
|
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| blood vessel development |
| positive regulation of fibroblast proliferation |
| positive regulation of NF-kappaB transcription factor activity |
| positive regulation of smooth muscle contraction |
| positive regulation of mitotic cell cycle |
| sphingolipid biosynthetic process |
| positive regulation of NF-kappaB import into nucleus |
| positive regulation of protein ubiquitination |
| regulation of interleukin-1 beta production |
| inflammatory response |
| regulation of tumor necrosis factor-mediated signaling pathway |
| sphingoid catabolic process |
| 'de novo' posttranslational protein folding |
| protein kinase C-activating G-protein coupled receptor signaling pathway |
| positive regulation of angiogenesis |
| phospholipid metabolic process |
| brain development |
| positive regulation of cell migration |
| positive regulation of cell growth |
| calcium-mediated signaling |
| sphingosine metabolic process |
| Cellular Component |
| cytosol |
| plasma membrane |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| diacylglycerol kinase activity |
| Molecular Function |
| calmodulin binding |
| DNA binding |
| magnesium ion binding |
| D-erythro-sphingosine kinase activity |
| diacylglycerol kinase activity |
| sphinganine kinase activity |
| ATP binding |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
| activation of protein kinase c activity by g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Calcium signaling pathway | Not Available |  | | VEGF signaling pathway | Not Available |  | | Fc gamma R-mediated phagocytosis | Not Available |  | | Tuberculosis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q25.2 |
| SNPs
| SPHK1 |
| Gene Sequence
|
>1155 bp
ATGGATCCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCCGCGTGCTGGTGCTG
CTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCC
CTTTTGGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCG
CGGGAGCTGGTGCGGTCGGAGGAGCTGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGA
GACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCTGACTGGGAGACCGCC
ATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTG
AACCATTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTA
TTGCTGTGCCGCCGGCTGCTGTCACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGG
CTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCTGATGTGGACCTAGAG
AGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACTTTCCTGCGTCTG
GCAGCCTTGCGCACTTACCGCGGCCGACTGGCTTACCTCCCTGTAGGAAGAGTGGGTTCC
AAGACACCTGCCTCCCCCGTTGTGGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCA
CTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAGGACTTTGTGCTAGTC
CTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGT
GCAGCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTG
CGCCTCTTCCTGGCCATGGAGAAGGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTA
TATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAAGGTATGTTTGCAGTG
GATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGG
ATGGTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCA
GAAGAGCCCTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 42517.245 |
| Theoretical pI
| 7.115 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sphingosine kinase 1
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
|
| External Links |
|---|
| GenBank ID Protein
| 9909361 |
| UniProtKB/Swiss-Prot ID
| Q9NYA1 |
| UniProtKB/Swiss-Prot Entry Name
| SPHK1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF200328 |
| GeneCard ID
| SPHK1 |
| GenAtlas ID
| SPHK1 |
| HGNC ID
| HGNC:11240 |
| References |
|---|
| General References
| Not Available |