| Identification |
|---|
| HMDB Protein ID
| CDBP03936 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras GTPase-activating protein-binding protein 1 |
| Description
| Not Available |
| Synonyms
|
- ATP-dependent DNA helicase VIII
- G3BP-1
- GAP SH3 domain-binding protein 1
- hDH VIII
|
| Gene Name
| G3BP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.
|
| GO Classification
|
| Biological Process |
| Ras protein signal transduction |
| nucleic acid phosphodiester bond hydrolysis |
| transport |
| Cellular Component |
| cytosol |
| cytoplasm |
| plasma membrane |
| nucleus |
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
| Molecular Function |
| DNA binding |
| endonuclease activity |
| ATP-dependent RNA helicase activity |
| ATP binding |
| ATP-dependent DNA helicase activity |
| RNA binding |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cell membrane
- Nucleus
- Cytoplasm
- Cytoplasm
- cytosol
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q33.1 |
| SNPs
| G3BP1 |
| Gene Sequence
|
>1401 bp
ATGGTGATGGAGAAGCCTAGTCCCCTGCTGGTCGGGCGGGAATTTGTGAGACAGTATTAC
ACACTGCTGAACCAGGCCCCAGACATGCTGCATAGATTTTATGGAAAGAACTCTTCTTAT
GTCCATGGGGGATTGGATTCAAATGGAAAGCCAGCAGATGCAGTCTACGGACAGAAAGAA
ATCCACAGGAAAGTGATGTCACAAAACTTCACCAACTGCCACACCAAGATTCGCCATGTT
GATGCTCATGCCACGCTAAATGATGGTGTGGTAGTCCAGGTGATGGGGCTTCTCTCTAAC
AACAACCAGGCTTTGAGGAGATTCATGCAAACGTTTGTCCTTGCTCCTGAGGGGTCTGTT
GCAAATAAATTCTATGTTCACAATGATATCTTCAGATACCAAGATGAGGTCTTTGGTGGG
TTTGTCACTGAGCCTCAGGAGGAGTCTGAAGAAGAAGTAGAGGAACCTGAAGAAAGACAG
CAAACACCTGAGGTGGTACCTGATGATTCTGGAACTTTCTATGATCAGGCAGTTGTCAGT
AATGACATGGAAGAACATTTAGAGGAGCCTGTTGCTGAACCAGAGCCTGATCCTGAACCA
GAACCAGAACAAGAACCTGTATCTGAAATCCAAGAGGAAAAGCCTGAGCCAGTATTAGAA
GAAACTGCCCCTGAGGATGCTCAGAAGAGTTCTTCTCCAGCACCTGCAGACATAGCTCAG
ACAGTACAGGAAGACTTGAGGACATTTTCTTGGGCATCTGTGACCAGTAAGAATCTTCCA
CCCAGTGGAGCTGTTCCAGTTACTGGGATACCACCTCATGTTGTTAAAGTACCAGCTTCA
CAGCCCCGTCCAGAGTCTAAGCCTGAATCTCAGATTCCACCACAAAGACCTCAGCGGGAT
CAAAGAGTGCGAGAACAACGAATAAATATTCCTCCCCAAAGGGGACCCAGACCAATCCGT
GAGGCTGGTGAGCAAGGTGACATTGAACCCCGAAGAATGGTGAGACACCCTGACAGTCAC
CAACTCTTCATTGGCAACCTGCCTCATGAAGTGGACAAATCAGAGCTTAAAGATTTCTTT
CAAAGTTATGGAAACGTGGTGGAGTTGCGCATTAACAGTGGTGGGAAATTACCCAATTTT
GGTTTTGTTGTGTTTGATGATTCTGAGCCTGTTCAGAAAGTCCTTAGCAACAGGCCCATC
ATGTTCAGAGGTGAGGTCCGTCTGAATGTCGAAGAGAAGAAGACTCGAGCTGCCAGGGAA
GGCGACCGACGAGATAATCGCCTTCGGGGACCTGGAGGCCCTCGAGGTGGGCTGGGTGGT
GGAATGAGAGGCCCTCCCCGTGGAGGCATGGTGCAGAAACCAGGATTTGGAGTGGGAAGG
GGGCTTGCGCCACGGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 466 |
| Molecular Weight
| 52164.045 |
| Theoretical pI
| 5.515 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ras GTPase-activating protein-binding protein 1
MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE
IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV
ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS
NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ
TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD
QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF
QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE
GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ
|
| External Links |
|---|
| GenBank ID Protein
| 13937794 |
| UniProtKB/Swiss-Prot ID
| Q13283 |
| UniProtKB/Swiss-Prot Entry Name
| G3BP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC006997 |
| GeneCard ID
| G3BP1 |
| GenAtlas ID
| G3BP1 |
| HGNC ID
| HGNC:30292 |
| References |
|---|
| General References
| Not Available |