| Identification |
|---|
| HMDB Protein ID
| CDBP03499 |
| Secondary Accession Numbers
| Not Available |
| Name
| [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- PDP 2
- PDPC 2
- Pyruvate dehydrogenase phosphatase catalytic subunit 2
|
| Gene Name
| PDP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).
|
| GO Classification
|
| Biological Process |
| regulation of acetyl-CoA biosynthetic process from pyruvate |
| pyruvate metabolic process |
| protein dephosphorylation |
| Cellular Component |
| mitochondrial matrix |
| Component |
| macromolecular complex |
| protein complex |
| protein serine/threonine phosphatase complex |
| Function |
| phosphatase activity |
| protein serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| Molecular Function |
| metal ion binding |
| [pyruvate dehydrogenase (lipoamide)] phosphatase activity |
| magnesium-dependent protein serine/threonine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q22.1 |
| SNPs
| PDP2 |
| Gene Sequence
|
>1590 bp
ATGTCAAGTACTGTGTCCTACTGGATCTTAAATTCTACAAGGAACAGCATTGCCACATTG
CAAGGGGGTAGACGCTTATACTCCAGGTATGTCTCAAATAGGAATAAATTAAAATGGAGG
CTCTTTTCCCGGGTGCCACCCACCCTAAACAGTTCCCCATGTGGTGGCTTTACTCTGTGC
AAAGCCTACAGACACACATCAACAGAGGAAGATGATTTTCACTTGCAACTCAGCCCTGAG
CAGATAAATGAAGTGCTTCGAGCTGGCGAGACAACCCACAAGATTCTTGACCTTGAAAGC
AGAGTCCCAAATTCAGTGTTGCGGTTTGAGAGCAACCAGCTGGCTGCCAATTCCCCAGTG
GAGGACCGGCGAGGTGTAGCCTCCTGCCTGCAAACCAATGGACTGATGTTTGGCATCTTC
GATGGACATGGTGGTCATGCATGTGCCCAAGCAGTGAGCGAGAGGCTCTTCTACTATGTG
GCAGTGTCCCTGATGTCCCACCAGACCCTGGAGCACATGGAGGGAGCTATGGAAAGCATG
AAACCCTTGCTGCCCATCCTGCATTGGCTCAAGCACCCAGGGGACAGTATCTACAAGGAT
GTCACATCTGTGCATCTTGACCACCTCCGTGTCTATTGGCAGGAACTGCTTGATTTGCAC
ATGGAAATGGGACTAAGCATTGAAGAAGCATTAATGTACTCCTTCCAGAGACTGGATTCT
GACATCTCGCTGGAAATCCAGGCCCCCCTGGAAGATGAGGTGACAAGGAACCTGTCACTC
CAGGTTGCTTTCTCTGGGGCAACAGCTTGCATGGCCCATGTTGATGGAATTCACTTGCAC
GTGGCAAATGCTGGTGACTGCCGAGCCATCCTTGGTGTCCAAGAGGACAATGGCATGTGG
TCTTGTCTGCCCCTTACACGTGACCACAATGCCTGGAACCAGGCCGAGCTGTCCCGGCTA
AAGAGGGAGCACCCTGAGTCAGAGGACAGGACGATCATCATGGAGGACAGGCTACTGGGC
GTCCTCATCCCCTGCAGGGCCTTTGGGGATGTTCAGCTGAAGTGGAGTAAAGAGTTGCAG
CGCAGCATTCTGGAGAGGGGCTTCAATACCGAGGCCCTCAACATTTACCAGTTCACACCC
CCACACTACTACACTCCACCCTACCTGACTGCTGAGCCTGAGGTCACATACCACAGGCTG
AGGCCCCAGGATAAGTTCCTTGTGCTGGCCTCAGATGGCCTGTGGGACATGCTGAGCAAT
GAGGACGTGGTAAGGCTGGTGGTGGGGCACCTGGCTGAGGCAGATTGGCACAAGACAGAC
CTGGCCCAGAGACCCGCCAACTTGGGGCTCATGCAGAGCCTGCTGCTGCAGAGGAAAGCC
AGCGGGCTCCACGAGGCTGACCAAAATGCAGCCACGCGGCTGATCAGACATGCCATCGGG
AACAATGAGTATGGGGAGATGGAGGCAGAGCGGCTGGCGGCGATGCTGACATTGCCAGAG
GACTTGGCGAGGATGTACAGGGATGATATCACTGTCACTGTGGTGTATTTTAACTCAGAA
TCAATCGGTGCATATTACAAGGGGGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 529 |
| Molecular Weight
| 59977.46 |
| Theoretical pI
| 6.081 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLC
KAYRHTSTEEDDFHLQLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPV
EDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAMESM
KPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDS
DISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMW
SCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQ
RSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSN
EDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIG
NNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAYYKGG
|
| External Links |
|---|
| GenBank ID Protein
| 41349497 |
| UniProtKB/Swiss-Prot ID
| Q9P2J9 |
| UniProtKB/Swiss-Prot Entry Name
| PDP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020786.1 |
| GeneCard ID
| PDP2 |
| GenAtlas ID
| PDP2 |
| HGNC ID
| HGNC:30263 |
| References |
|---|
| General References
| Not Available |