Identification |
HMDB Protein ID
| CDBP02242 |
Secondary Accession Numbers
| Not Available |
Name
| Phosphoethanolamine/phosphocholine phosphatase |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| PHOSPHO1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in phosphatase activity |
Specific Function
| Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
|
GO Classification
|
Biological Process |
phosphatidylethanolamine biosynthetic process |
phosphatidylcholine biosynthetic process |
regulation of bone mineralization |
Cellular Component |
cytosol |
Function |
catalytic activity |
hydrolase activity |
phosphoric ester hydrolase activity |
phosphatase activity |
hydrolase activity, acting on ester bonds |
Molecular Function |
metal ion binding |
phosphocholine phosphatase activity |
phosphoethanolamine phosphatase activity |
pyrophosphatase activity |
Process |
metabolic process |
|
Cellular Location
|
- Cytoplasmic
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycerophospholipid metabolism | Not Available | | Phospholipid Biosynthesis | | |
|
Gene Properties |
Chromosome Location
| 17 |
Locus
| 17q21.32 |
SNPs
| PHOSPHO1 |
Gene Sequence
|
>804 bp
ATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGACGGCAGGATGGCC
GCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAGACTATCGTGGACGAA
AACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCTGCGA
GCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGC
GAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCCATCCCTTTGTCGCCA
GGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGATTCTC
ATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGC
CTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTG
CGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAAGGTG
CTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTAC
GTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCC
TTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGAGCCC
AGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTG
CAACAGGTGCTGAAGTCGTGCTGA
|
Protein Properties |
Number of Residues
| 267 |
Molecular Weight
| 32350.505 |
Theoretical pI
| 7.65 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Phosphoethanolamine/phosphocholine phosphatase
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC
|
External Links |
GenBank ID Protein
| 20196839 |
UniProtKB/Swiss-Prot ID
| Q8TCT1 |
UniProtKB/Swiss-Prot Entry Name
| PHOP1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AJ457189 |
GeneCard ID
| PHOSPHO1 |
GenAtlas ID
| PHOSPHO1 |
HGNC ID
| HGNC:16815 |
References |
General References
| Not Available |