Identification
HMDB Protein ID CDBP02242
Secondary Accession Numbers Not Available
Name Phosphoethanolamine/phosphocholine phosphatase
Description Not Available
Synonyms Not Available
Gene Name PHOSPHO1
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
GO Classification
Biological Process
phosphatidylethanolamine biosynthetic process
phosphatidylcholine biosynthetic process
regulation of bone mineralization
Cellular Component
cytosol
Function
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
hydrolase activity, acting on ester bonds
Molecular Function
metal ion binding
phosphocholine phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity
Process
metabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 17
Locus 17q21.32
SNPs PHOSPHO1
Gene Sequence
>804 bp
ATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGACGGCAGGATGGCC
GCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAGACTATCGTGGACGAA
AACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCTGCGA
GCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGC
GAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCCATCCCTTTGTCGCCA
GGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGATTCTC
ATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGC
CTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTG
CGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAAGGTG
CTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTAC
GTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCC
TTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGAGCCC
AGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTG
CAACAGGTGCTGAAGTCGTGCTGA
Protein Properties
Number of Residues 267
Molecular Weight 32350.505
Theoretical pI 7.65
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphoethanolamine/phosphocholine phosphatase
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC
GenBank ID Protein 20196839
UniProtKB/Swiss-Prot ID Q8TCT1
UniProtKB/Swiss-Prot Entry Name PHOP1_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ457189
GeneCard ID PHOSPHO1
GenAtlas ID PHOSPHO1
HGNC ID HGNC:16815
References
General References Not Available