| Identification |
|---|
| HMDB Protein ID
| CDBP01131 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity testis-specific protein kinase 2 |
| Description
| Not Available |
| Synonyms
|
- Testicular protein kinase 2
|
| Gene Name
| TESK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis |
| GO Classification
|
| Function |
| protein kinase activity |
| protein tyrosine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p32 |
| SNPs
| TESK2 |
| Gene Sequence
|
>1716 bp
ATGGATCGGAGCAAACGGAATTCAATTGCAGGATTTCCTCCACGTGTGGAGCGTCTTGAA
GAGTTTGAAGGAGGTGGTGGAGGAGAAGGAAATGTGAGCCAGGTGGGAAGAGTTTGGCCA
TCTTCGTATCGAGCTCTTATAAGTGCCTTTTCCAGACTGACGCGTTTGGATGATTTCACC
TGTGAAAAAATAGGGTCTGGCTTCTTTTCTGAAGTGTTCAAGGTACGACACCGAGCTTCT
GGTCAGGTGATGGCTCTTAAGATGAACACATTGAGCAGTAACCGGGCAAACATGCTGAAA
GAAGTACAGCTCATGAATAGACTCTCCCATCCCAACATCCTTAGGTTCATGGGTGTATGT
GTTCATCAAGGACAATTGCATGCACTTACAGAGTATATCAACTCCGGGAACCTGGAACAG
TTGCTAGACAGTAACCTGCATTTGCCTTGGACTGTGAGGGTAAAACTGGCCTATGACATA
GCAGTGGGCCTCAGCTACCTTCACTTCAAAGGCATTTTTCATCGGGACCTCACATCTAAG
AACTGCCTGATAAAGAGGGATGAGAATGGTTACTCTGCAGTGGTAGCTGACTTTGGCCTG
GCTGAGAAGATCCCCGATGTCAGCATGGGGAGTGAGAAGCTGGCCGTGGTGGGTTCCCCA
TTCTGGATGGCACCTGAGGTTCTCCGAGATGAGCCCTATAATGAAAAGGCAGATGTGTTC
TCTTATGGTATCATCCTCTGCGAGATCATCGCCCGCATCCAGGCCGATCCGGACTATCTT
CCCCGCACAGAGAATTTCGGGCTGGACTATGATGCTTTCCAGCACATGGTGGGAGACTGT
CCCCCAGATTTTCTGCAACTTACTTTCAACTGCTGTAACATGGATCCCAAACTGCGCCCA
TCTTTTGTGGAGATTGGGAAGACCCTGGAGGAAATTCTGAGCCGCCTACAGGAAGAAGAG
CAGGAGAGGGATAGGAAGCTGCAGCCCACAGCCAGGGGACTCTTGGAGAAAGCACCTGGG
GTGAAGCGACTAAGCTCACTGGATGACAAGATCCCCCACAAGTCACCATGCCCAAGACGT
ACCATCTGGCTGTCTCGAAGCCAGTCAGATATCTTTTCCCGTAAGCCCCCACGTACAGTG
AGTGTCTTGGACCCATACTACCGGCCACGAGATGGTGCTGCCCGCACCCCCAAAGTCAAC
CCTTTTAGTGCTCGCCAGGACCTCATGGGGGGCAAGATCAAGTTTTTTGACCTGCCCAGC
AAGTCTGTCATCTCTCTGGTATTTGACCTGGATGCACCAGGGCCCGGAACTATGCCCCTG
GCTGACTGGCAGGAGCCCCTGGCCCCACCTATTCGCCGGTGGCGTTCCTTGCCTGGTTCG
CCTGAGTTCTTGCATCAAGAGGCTTGTCCATTTGTGGGCCGGGAAGAATCGCTATCTGAT
GGGCCCCCACCACGCCTAAGTAGTCTCAAGTACAGAGTTAAAGAGATCCCACCATTCCGG
GCATCTGCCCTACCAGCTGCTCAAGCCCATGAGGCTATGGACTGCTCCATTCTCCAGGAA
GAAAATGGTTTTGGGTCCAGGCCCCAGGGGACCAGTCCATGCCCTGCGGGTGCTTCTGAG
GAGATGGAGGTAGAAGAAAGGCCAGCAGGCTCAACTCCAGCCACCTTCTCCACCTCAGGC
ATAGGCCTGCAAACCCAGGGAAAGCAGGATGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 571 |
| Molecular Weight
| 63638.8 |
| Theoretical pI
| 7.06 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dual specificity testis-specific protein kinase 2
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
EMEVEERPAGSTPATFSTSGIGLQTQGKQDG
|
| External Links |
|---|
| GenBank ID Protein
| 15207801 |
| UniProtKB/Swiss-Prot ID
| Q96S53 |
| UniProtKB/Swiss-Prot Entry Name
| TESK2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB057597 |
| GeneCard ID
| TESK2 |
| GenAtlas ID
| TESK2 |
| HGNC ID
| HGNC:11732 |
| References |
|---|
| General References
| Not Available |