Cannabis Compound Database: Showing Protein Crossover junction endonuclease MUS81 (CDBP03974)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03974

Secondary Accession Numbers

Not Available

Name

Crossover junction endonuclease MUS81

Description

Not Available

Synonyms

Not Available

Gene Name

MUS81

Protein Type

Enzyme

Biological Properties

General Function

Involved in DNA binding

Specific Function

Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks

GO Classification

Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
protein binding
nucleic acid binding
dna binding
nuclease activity
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
dna metabolic process
dna repair

Cellular Location

Nucleus
nucleolus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11q13

SNPs

MUS81

Gene Sequence

>1656 bp
ATGGCGGCCCCGGTCCGCCTGGGCCGGAAGCGCCCGCTGCCTGCCTGTCCCAACCCGCTC
TTCGTTCGCTGGCTGACCGAGTGGCGGGACGAGGCGACCCGCAGCAGGCACCGCACGCGC
TTCGTATTTCAGAAGGCGCTGCGTTCCCTCCGACGGTACCCACTGCCGCTGCGCAGCGGG
AAGGAAGCTAAGATCCTACAGCACTTCGGAGACGGGCTCTGCCGGATGCTGGACGAGCGG
CTGCAGCGGCACCGAACATCGGGCGGTGACCATGCCCCGGACTCACCATCTGGAGAGAAC
AGTCCAGCCCCGCAGGGGCGACTTGCGGAAGTCCAGGACTCTTCCATGCCAGTTCCTGCC
CAGCCCAAAGCGGGAGGCTCTGGCAGCTACTGGCCAGCTCGGCACTCAGGAGCCCGAGTG
ATACTGCTGGTGCTCTACCGGGAGCACCTGAATCCTAATGGTCACCACTTCTTAACCAAG
GAGGAGCTGCTGCAGAGGTGTGCTCAGAAGTCCCCCAGGGTAGCCCCTGGGAGTGCCCCA
CCCTGGCCAGCCCTCCGCTCCCTCCTTCACAGGAACCTGGTCCTCAGGACACACCAGCCA
GCCAGGTACTCATTGACCCCAGAGGGCCTGGAGCTGGCCCAGAAGTTGGCCGAGTCAGAA
GGCCTGAGCTTGCTGAATGTGGGCATCGGGCCCAAGGAGCCCCCTGGGGAGGAGACAGCA
GTGCCAGGAGCAGCTTCAGCAGAGCTTGCCAGTGAAGCAGGGGTCCAGCAGCAGCCACTG
GAGCTGAGGCCTGGAGAGTACAGGGTGCTGTTGTGTGTGGACATTGGCGAGACCCGGGGG
GGCGGGCACAGGCCGGAGCTGCTCCGAGAGCTACAGCGGCTGCACGTGACCCACACGGTG
CGCAAGCTGCACGTTGGAGATTTTGTGTGGGTGGCTCAGGAGACCAATCCTAGAGACCCA
GCAAACCCTGGGGAGTTGGTACTGGATCACATTGTGGAGCGCAAGCGACTGGATGACCTT
TGCAGCAGCATCATCGACGGCCGCTTCCGGGAGCAGAAGTTCCGACTGAAGCGCTGTGGT
CTGGAGCGCCGGGTATACCTGGTGGAAGAGCATGGTTCCGTCCACAACCTCAGCCTTCCT
GAGAGCACACTGCTGCAGGCTGTCACCAACACTCAGGTCATTGATGGCTTTTTTGTGAAG
CGCACAGCAGACATTAAGGAGTCAGCCGCCTACCTGGCCCTCTTGACTCGGGGCCTGCAG
AGACTCTACCAGGGCCACACCCTACGCAGCCGCCCCTGGGGAACCCCTGGGAACCCTGAA
TCAGGGGCCATGACCTCTCCAAACCCTCTCTGCTCACTCCTCACCTTCAGTGACTTCAAC
GCAGGAGCCATCAAGAATAAGGCCCAGTCGGTGCGAGAAGTGTTTGCCCGGCAGCTGATG
CAGGTGCGCGGAGTGAGTGGGGAGAAGGCAGCAGCCCTGGTGGATCGATACAGCACCCCT
GCCAGCCTCCTGGCCGCCTATGATGCCTGTGCCACCCCCAAGGAACAAGAGACACTGCTG
AGCACCATTAAGTGTGGGCGTCTACAGAGGAATCTGGGGCCTGCTCTGAGCAGGACCTTA
TCCCAGCTCTACTGCAGCTACGGCCCCTTGACCTGA

Protein Properties

Number of Residues

551

Molecular Weight

61172.4

Theoretical pI

10.22

Pfam Domain Function

ERCC4 (PF02732 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Crossover junction endonuclease MUS81
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSG
KEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPA
QPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAR
PWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETA
VPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTV
RKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCG
LERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQ
RLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLM
QVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTL
SQLYCSYGPLT

External Links

GenBank ID Protein

16755672

UniProtKB/Swiss-Prot ID

Q96NY9

UniProtKB/Swiss-Prot Entry Name

MUS81_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF425646

GeneCard ID