Identification |
HMDB Protein ID
| CDBP01376 |
Secondary Accession Numbers
| Not Available |
Name
| Mitogen-activated protein kinase 4 |
Description
| Not Available |
Synonyms
|
- ERK-4
- Extracellular signal-regulated kinase 4
- MAP kinase 4
- MAP kinase isoform p63
- MAPK 4
- p63-MAPK
|
Gene Name
| MAPK4 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in MAP kinase activity |
Specific Function
| Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle |
GO Classification
|
Function |
protein kinase activity |
protein serine/threonine kinase activity |
receptor signaling protein serine/threonine kinase activity |
map kinase activity |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
Process |
phosphorus metabolic process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 18q21.2 |
SNPs
| MAPK4 |
Gene Sequence
|
>1764 bp
ATGGCTGAGAAGGGTGACTGCATCGCCAGTGTCTATGGGTATGACCTCGGTGGGCGCTTT
GTTGACTTCCAACCCCTGGGCTTCGGTGTCAATGGTTTGGTGCTGTCGGCCGTGGACAGC
CGGGCCTGCCGGAAGGTCGCTGTGAAGAAGATTGCCCTGAGCGATGCCCGCAGCATGAAG
CACGCGCTCCGAGAGATCAAGATCATTCGGCGCCTGGACCACGACAACATCGTCAAAGTG
TACGAGGTGCTCGGTCCCAAGGGCACTGACCTGCAGGGTGAGCTGTTCAAGTTCAGCGTG
GCGTACATCGTCCAGGAGTACATGGAGACCGACCTGGCACGCCTGCTGGAGCAGGGCACG
CTGGCAGAAGAGCATGCCAAGCTGTTCATGTACCAGCTGCTCCGCGGGCTCAAGTACATC
CACTCCGCCAACGTGCTGCACAGGGACCTGAAGCCCGCCAACATCTTCATCAGCACAGAG
GACCTCGTGCTCAAGATTGGGGATTTCGGGTTGGCAAGGATCGTTGATCAGCATTACTCC
CACAAGGGTTATCTGTCAGAAGGGTTGGTAACAAAGTGGTACCGTTCCCCACGACTGCTC
CTTTCCCCCAATAACTACACCAAAGCCATCGACATGTGGGCCGCCGGCTGCATCCTGGCT
GAGATGCTTACGGGGAGAATGCTCTTTGCTGGGGCCCATGAGCTGGAGCAGATGCAACTC
ATCCTGGAGACCATCCCTGTAATCCGGGAGGAAGACAAGGACGAGCTGCTCAGGGTGATG
CCTTCCTTTGTCAGCAGCACCTGGGAGGTGAAGAGGCCTCTGCGCAAGCTGCTCCCTGAA
GTGAACAGTGAAGCCATCGACTTTCTGGAGAAGATCCTGACCTTTAACCCCATGGATCGC
CTAACAGCTGAGATGGGGCTGCAACACCCCTACATGAGCCCATACTCGTGCCCTGAGGAC
GAGCCCACCTCACAACACCCCTTCCGCATTGAGGATGAGATCGACGACATCGTGCTGATG
GCCGCTAACCAGAGCCAGCTGTCCAACTGGGACACGTGCAGTTCCAGGTACCCTGTGAGC
CTGTCGTCGGACCTGGAGTGGCGGCCTGACCGGTGCCAGGACGCCAGCGAGGTACAGCGC
GACCCGCGCGCGGGTTCGGCGCCACTGGCTGAGGACGTGCAGGTGGACCCGCGCAAGGAC
TCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAGTCGCACTCGTCCATGGAGCGCGCCTTC
GAGGCCGACTACGGGCGCTCCTGCGACTACAAGGTGGGGTCGCCGTCCTACCTGGACAAG
CTGCTGTGGCGCGACAACAAGCCGCACCACTACTCGGAGCCCAAGCTCATCCTGGACCTG
TCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCCACGGCCACGGGGCTGGCGGACACGGGG
GCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTGGAGATCGCGCAGTGGGTCAAGAGCACG
CAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCCGACGACCCCGAGCGCCGCTTGTCTGCC
TCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGCGGCGCCAGCCCCCAGTTCGACCTGGAC
GTGTTCATCTCCCGCGCCCTGAAGCTCTGCACCAAGCCCGAGGACCTGCCGGACAATAAA
CTGGGCGACCTCAATGGTGCGTGCATCCCCGAGCACCCTGGCGACCTCGTGCAGACCGAG
GCCTTCTCCAAAGAAAGGTGGTGA
|
Protein Properties |
Number of Residues
| 587 |
Molecular Weight
| 65921.0 |
Theoretical pI
| 5.11 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Mitogen-activated protein kinase 4
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK
HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT
LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS
HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL
ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR
LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS
LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF
EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG
AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD
VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
|
External Links |
GenBank ID Protein
| 89276769 |
UniProtKB/Swiss-Prot ID
| P31152 |
UniProtKB/Swiss-Prot Entry Name
| MK04_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_002747.3 |
GeneCard ID
| MAPK4 |
GenAtlas ID
| MAPK4 |
HGNC ID
| HGNC:6878 |
References |
General References
| Not Available |