| Identification |
|---|
| HMDB Protein ID
| CDBP01393 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein kinase WNK2 |
| Description
| Not Available |
| Synonyms
|
- Antigen NY-CO-43
- Protein kinase lysine-deficient 2
- Protein kinase with no lysine 2
- Serologically defined colon cancer antigen 43
|
| Gene Name
| WNK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| ATP + a protein = ADP + a phosphoprotein |
| GO Classification
|
| Function |
| protein kinase activity |
| protein serine/threonine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q22.3 |
| SNPs
| WNK2 |
| Gene Sequence
|
>6894 bp
ATGGACGGCGATGGCGGCCGCCGAGACGTCCCCGGCACGCTGATGGAGCCCGGGCGCGGC
GCGGGGCCCGCGGGCATGGCGGAGCCTCGGGCGAAGGCGGCGCGGCCGGGGCCCCAGCGC
TTTCTGCGGCGCAGCGTGGTAGAGTCGGACCAGGAGGAGCCGCCGGGCTTGGAGGCAGCC
GAGGCGCCGGGCCCGCAGCCCCCGCAGCCCCTGCAGCGCCGGGTGCTTCTGCTCTGCAAG
ACGCGCCGCCTCATCGCGGAGCGCGCCCGCGGACGCCCCGCCGCCCCCGCGCCCGCAGCG
CTGGTAGCGCAGCCGGGAGCCCCCGGAGCCCCCGCGGACGCCGGCCCCGAGCCCGTGGGC
ACGCAGGAGCCCGGCCCGGACCCCATCGCAGCCGCTGTCGAAACCGCGCCTGCCCCCGAC
GGCGGCCCCAGGGAGGAGGCGGCGGCGACCGTGAGGAAGGAGGATGAGGGGGCGGCCGAG
GCGAAGCCTGAGCCCGGGCGCACTCGCCGGGACGAGCCCGAAGAGGAGGAGGACGACGAG
GACGACCTCAAGGCCGTGGCCACCTCTCTGGACGGCCGCTTCCTCAAGTTCGACATCGAG
CTGGGCCGCGGTTCCTTCAAGACGGTCTACAAGGGGCTGGACACGGAGACCTGGGTGGAG
GTGGCCTGGTGTGAGCTGCAGGACCGGAAGCTCACCAAGCTGGAGCGGCAGCGGTTCAAG
GAAGAGGCTGAGATGCTGAAAGGCCTGCAGCACCCCAACATCGTGCGCTTCTACGACTTC
TGGGAGTCCAGCGCCAAGGGCAAGCGGTGCATTGTGCTGGTGACGGAGCTGATGACCTCA
GGGACGCTGAAGACATACCTGAAGCGGTTCAAGGTGATGAAGCCCAAGGTTCTCCGCAGC
TGGTGCCGGCAGATCCTGAAGGGCCTGCTGTTCCTGCACACAAGGACGCCACCCATCATC
CACCGAGACCTGAAATGTGACAATATTTTCATCACCGGACCAACTGGGTCTGTGAAGATT
GGCGACTTGGGCCTGGCCACTCTGAAAAGAGCGTCATTTGCCAAAAGTGTGATAGGTACT
CCCGAGTTCATGGCGCCCGAGATGTACGAGGAGCACTACGATGAGTCCGTGGACGTCTAT
GCCTTTGGGATGTGCATGCTGGAGATGGCCACCTCGGAGTACCCCTACTCGGAGTGCCAG
AATGCGGCCCAGATCTACCGCAAGGTCACCTGTGGTATCAAGCCGGCCAGCTTTGAGAAA
GTGCACGATCCTGAAATCAAGGAGATTATTGGGGAGTGTATCTGCAAAAACAAGGAGGAA
AGGTACGAGATCAAAGACCTGCTGAGCCACGCCTTCTTCGCAGAGGACACAGGCGTGAGG
GTGGAGCTCGCGGAGGAGGACCACGGCAGGAAGTCCACCATCGCCCTGAGGCTCTGGGTG
GAAGACCCCAAGAAACTGAAGGGAAAGCCCAAGGACAATGGAGCCATAGAGTTCACCTTC
GACCTGGAGAAGGAGACGCCGGATGAGGTGGCCCAAGAGATGATTGAGTCTGGATTCTTC
CACGAGAGTGACGTCAAGATCGTGGCCAAGTCCATCCGTGACCGCGTGGCCTTGATCCAG
TGGCGGCGGGAGAGGATCTGGCCCGCGCTGCAGCCCAAGGAGCAGCAGGATGTGGGCAGC
CCGGACAAGGCCAGGGGTCCGCCGGTGCCCCTGCAGGTCCAGGTGACCTACCATGCACAG
GCTGGGCAGCCCGGGCCACCAGAGCCCGAGGAGCCGGAGGCCGACCAGCACCTCCTGCCA
CCTACGTTGCCGACCAGCGCCACCTCCCTGGCCTCGGACAGCACCTTCGACAGCGGCCAG
GGCTCTACCGTGTACTCAGACTCGCAGAGCAGCCAGCAGAGCGTGATGCTTGGCTCCCTT
GCCGACGCAGCGCCGTCCCCGGCCCAGTGTGTGTGCAGCCCCCCTGTGAGCGAGGGGCCC
GTCCTGCCGCAGAGCCTGCCCTCGCTGGGGGCCTACCAGCAGCCCACGGCTGCACCTGGC
TTGCCGGTGGGCTCTGTCCCGGCCCCCGCCTGCCCTCCGTCCCTCCAGCAGCACTTCCCG
GATCCGGCCATGAGCTTCGCCCCCGTGCTGCCGCCGCCCAGCACCCCCATGCCCACGGGC
CCAGGCCAGCCAGCACCCCCCGGCCAGCAGCCTCCTCCGCTGGCCCAGCCGACACCCCTG
CCGCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCA
CCGTACCTGGCTCCAGCCTCCCAGGTGGGGGCCCCCGCTCAGCTGAAGCCCCTCCAGATG
CCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTT
GTGCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTG
CCGACCGCGACTGTGCCTCCCGTGCCACCACCTCAGTATTTCTCTCCAGCCGTGATCTTG
CCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAG
CTGCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCA
CCGGCCACTATCCCCCTGCTGGCCGTAGCCCCACCGGGCGTGGCTGCCCTGTCCATTCAT
TCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCG
CCTACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCA
CAGCCGGCACTGCCTCCACAACCCACACTGCCCCCACAACCCGTGCTGCCCCCGCAACCC
ACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTG
CCCCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTG
CGCCCTGAGCCCCTCCAGCCCCACCTTCCTGAACAAGCTGCTCCAGCTGCTACACCAGGG
AGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCC
ACCGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCT
GCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAGCTCCCTGGCCACGGTGTCTGCCTCTGTG
CAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGC
GGGCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAG
GAGCAGGCCTCACAGGACAAGCCGCCCGGCCTCCCGCAGAGCTGTGAGAGCTATGGAGGT
TCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGC
AGGCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGG
CAGGAGAGGGCCAGCCGGCCCCGGCTTACCATCTTGAACGTGTGCAACACTGGGGACAAG
ATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTG
GACGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAG
GCCGAGCGGGAAACGTTCATCGAGCAGATGAAGGATGTCATGGACAAGGCAGAGGACATG
CTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTC
AGCACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTG
TATCAGCAGAACGTCCTGCACACCGGGAAGAGGTGGTTCATCATCTGTCCGGTGGCTGAG
CACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCA
GAAGCCAGCCAAGGTCCATGCAGGGGGCTCACCCTGCCCTGTCTCCCATGGCGCAGAGCA
GCCTGTGGGGCTGTGTTCCTATCCTTGTTTTCTGCTGAATCAGCTCAGTCAAAGCAGCCT
CCAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCC
AGTCAGCAGCTCCTGAGCCAGGCGGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCT
TTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCCAGCCACC
AGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCT
CAGGGGCTGACCAGTGAGCTCGAGACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCG
CTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGAGGCTGCC
TCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGC
CCCCACAGCGGGACCCCACAGCCCGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCA
GTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCCCACCGTC
CCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGC
TTTGTGGACAGCACCATCAAGAGCCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAG
CACGTGCCCACCTCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAGAGACTTC
ACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCC
CTGCCCCCAGTGCCTAAGGAGGCGGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTG
GAGAAGTCAGAACTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTCCTCGTCA
ATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTG
GCCTCAGACTCCCATGTGGTCCCCAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCT
GCACGTGTGGAGCCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGCAGAGCCC
CCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCT
CGAGCTTTGGGGTCCCCTCGGAAACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAG
ACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTCCCCCCAC
AGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGAC
GTGAAGCTGGCAGTGCGGCGGGCGCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAG
CCCGTGTCCAGCGACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCAGAAGCAG
GCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTC
CTGCAGAGGCCTTCTCGGGCCGGCTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATG
AAGGTCCCCACGATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAGCAGCGAC
AATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAG
CACCTGAAGGAGATCTCGGAGCTGCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTAC
CGCCGCCTGGGCAAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACCCCCCACT
GGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTG
GTGCGGCAGCTCAAGGTCGTGGCCTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGC
CCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCACGGGCCTG
AGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGAC
ATCTGCTCCGGCTTAGCCAGTGATGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTAC
CACCCAACGTCTGAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCGATTCCTC
AGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAA
CACAGCAGTAGGTCCTCCACCAGCAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCC
GCCCTGCACGTCCAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTTCACGGAC
GACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAG
CCCACGCTCAACCAGCTGAAGCAGACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGC
TGGGCTGCCCCTGGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGGGATGCCA
CGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACC
CTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTT
GGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAG
CGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGTTCGCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 2297 |
| Molecular Weight
| 242673.8 |
| Theoretical pI
| 6.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine/threonine-protein kinase WNK2
MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAA
EAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVG
TQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDE
DDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFK
EEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS
WCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGT
PEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEK
VHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWV
EDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQ
WRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLP
PTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGP
VLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTG
PGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQM
PQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVIL
PSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIH
SAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQP
TLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPG
SQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASV
QSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGG
SDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDK
MVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDM
LSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE
HPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQP
PDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPAT
STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA
STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTV
PPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDF
TLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSS
MTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEP
PPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPH
SLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQ
ASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSD
NDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPT
GRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGL
SGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFL
SGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTD
DLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMP
RLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQ
RVGSKTASFAASDPVRS
|
| External Links |
|---|
| GenBank ID Protein
| 57161866 |
| UniProtKB/Swiss-Prot ID
| Q9Y3S1 |
| UniProtKB/Swiss-Prot Entry Name
| WNK2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ242724 |
| GeneCard ID
| WNK2 |
| GenAtlas ID
| WNK2 |
| HGNC ID
| HGNC:14542 |
| References |
|---|
| General References
| Not Available |