| Identification |
|---|
| HMDB Protein ID
| CDBP03992 |
| Secondary Accession Numbers
| Not Available |
| Name
| Diphosphoinositol polyphosphate phosphohydrolase 2 |
| Description
| Not Available |
| Synonyms
|
- DIPP-2
- Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
- Nucleoside diphosphate-linked moiety X motif 4
- Nudix motif 4
|
| Gene Name
| NUDT4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
|
| GO Classification
|
| Biological Process |
| cyclic-nucleotide-mediated signaling |
| intracellular transport |
| regulation of RNA export from nucleus |
| calcium-mediated signaling |
| cyclic nucleotide metabolic process |
| Cellular Component |
| intracellular |
| cytoplasm |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| snoRNA binding |
| diphosphoinositol-polyphosphate diphosphatase activity |
| inositol diphosphate tetrakisphosphate diphosphatase activity |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity |
| inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity |
| inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q21 |
| SNPs
| NUDT4 |
| Gene Sequence
|
>543 bp
ATGATGAAGTTCAAGCCCAACCAGACGCGGACCTACGACCGCGAGGGCTTCAAGAAGCGG
GCGGCGTGCCTGTGCTTCCGGAGCGAGCAGGAGGACGAGGTGCTGCTGGTGAGTAGCAGC
CGGTACCCAGACCAGTGGATTGTCCCAGGAGGAGGAATGGAACCCGAGGAGGAACCTGGC
GGTGCTGCCGTGAGGGAAGTTTATGAGGAGGCTGGAGTCAAAGGAAAACTAGGCAGACTT
CTGGGCATATTTGAGAACCAAGACCGAAAGCACAGAACATATGTTTATGTTCTAACAGTC
ACTGAAATATTAGAAGATTGGGAAGATTCTGTTAATATTGGAAGGAAGAGAGAGTGGTTC
AAAGTAGAAGATGCTATCAAAGTTCTCCAGTGTCATAAACCTGTACATGCAGAGTATCTG
GAAAAGCTAAAGCTGGGTTGTTCCCCAGCCAATGGAAATTCTACAGTCCCTTCCCTTCCG
GATAATAATGCCTTGTTTGTAACCGCTGCACAGACCTCTGGGTTGCCATCTAGTGTAAGA
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 180 |
| Molecular Weight
| 20305.895 |
| Theoretical pI
| 6.351 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diphosphoinositol polyphosphate phosphohydrolase 2
MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG
GAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWF
KVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR
|
| External Links |
|---|
| GenBank ID Protein
| 40317632 |
| UniProtKB/Swiss-Prot ID
| Q9NZJ9 |
| UniProtKB/Swiss-Prot Entry Name
| NUDT4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_019094.4 |
| GeneCard ID
| NUDT4 |
| GenAtlas ID
| NUDT4 |
| HGNC ID
| HGNC:8051 |
| References |
|---|
| General References
| Not Available |