Identification
HMDB Protein ID CDBP03987
Secondary Accession Numbers Not Available
Name Probable 8-oxo-dGTP diphosphatase NUDT15
Description Not Available
Synonyms
  1. 8-oxo-dGTPase NUDT15
  2. MTH2
  3. MutT homolog 2
  4. Nucleoside diphosphate-linked moiety X motif 15
  5. Nudix motif 15
  6. 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15
Gene Name NUDT15
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
GO Classification
Biological Process
GTP catabolic process
dGTP catabolic process
Function
catalytic activity
hydrolase activity
Molecular Function
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
metal ion binding
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 13
Locus 13q14.2
SNPs NUDT15
Gene Sequence
>495 bp
ATGACGGCCAGCGCACAGCCGCGCGGGCGGCGGCCAGGAGTCGGAGTCGGAGTCGTGGTG
ACCAGCTGCAAGCATCCGCGTTGCGTCCTCCTGGGGAAGAGGAAAGGCTCGGTTGGAGCT
GGCAGTTTCCAACTCCCTGGAGGTCATCTGGAGTTCGGTGAAACCTGGGAAGAATGTGCT
CAAAGGGAAACCTGGGAAGAAGCAGCTCTTCACCTGAAAAATGTTCACTTTGCCTCAGTT
GTGAATTCTTTCATTGAGAAGGAGAATTACCATTATGTTACTATATTAATGAAAGGAGAA
GTGGATGTGACTCATGATTCAGAACCAAAGAATGTAGAGCCTGAAAAAAATGAAAGTTGG
GAGTGGGTTCCTTGGGAAGAACTACCTCCCCTGGACCAGCTTTTCTGGGGACTGCGTTGT
TTAAAAGAACAAGGCTATGATCCATTTAAAGAAGATCTGAACCATCTGGTGGGATACAAA
GGAAATCATCTCTAG
Protein Properties
Number of Residues 164
Molecular Weight 18608.965
Theoretical pI 6.133
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESW
EWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL
GenBank ID Protein 7023325
UniProtKB/Swiss-Prot ID Q9NV35
UniProtKB/Swiss-Prot Entry Name NUD15_HUMAN
PDB IDs Not Available
GenBank Gene ID AK001818
GeneCard ID NUDT15
GenAtlas ID NUDT15
HGNC ID HGNC:23063
References
General References Not Available