3988
CDBP03987
Probable 8-oxo-dGTP diphosphatase NUDT15
Q9NV35
NUD15_HUMAN
true
false
Enzyme
Homo_sapiens
NUDT15
164
18608.965
6.133
Involved in hydrolase activity
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
AK001818
7023325
NUDT15
13
13q14.2
NUDT15
HGNC:23063
true
hsa:55270
NP_060753.1:NM_018283.1
Magnesium or manganese. Magnesium may be the real cofactor in vivo
Interacts with PCNA; interaction is disrupted in response to UV irradiation
2020-06-12T23:07:20Z
2020-07-28T02:29:18Z
0
1
0