Cannabis Compound Database: Showing Protein 5'(3')-deoxyribonucleotidase, cytosolic type (CDBP00006)

Identification Biological properties Gene properties Protein properties External links References XML Show 22 compounds

Identification

HMDB Protein ID

CDBP00006

Secondary Accession Numbers

Not Available

Name

5'(3')-deoxyribonucleotidase, cytosolic type

Description

Not Available

Synonyms

Cytosolic 5',3'-pyrimidine nucleotidase
Deoxy-5'-nucleotidase 1
dNT-1

Gene Name

NT5C

Protein Type

Enzyme

Biological Properties

General Function

Involved in metal ion binding

Specific Function

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

GO Classification

Biological Process
purine nucleobase metabolic process
purine nucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
pyrimidine deoxyribonucleotide catabolic process
Cellular Component
cytosol
mitochondrion
nucleus
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
5'-nucleotidase activity
metal ion binding
pyrimidine nucleotide binding

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Gemcitabine Action Pathway		Not Available
Gemcitabine Metabolism Pathway		Not Available
Lamivudine Metabolism Pathway		Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

NT5C

Gene Sequence

>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

Protein Properties

Number of Residues

201

Molecular Weight

Not Available

Theoretical pI

Not Available

Pfam Domain Function

NT5C (PF06941 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>5'(3')-deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

External Links

GenBank ID Protein

7524492

UniProtKB/Swiss-Prot ID

Q8TCD5

UniProtKB/Swiss-Prot Entry Name

NT5C_HUMAN

PDB IDs