| Identification |
|---|
| HMDB Protein ID
| CDBP00830 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphoserine phosphatase |
| Description
| Not Available |
| Synonyms
|
- L-3-phosphoserine phosphatase
- O-phosphoserine phosphohydrolase
- PSP
- PSPase
|
| Gene Name
| PSPH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| response to mechanical stimulus |
| response to testosterone stimulus |
| response to nutrient levels |
| L-serine biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoserine phosphatase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| magnesium ion binding |
| phosphoserine phosphatase activity |
| calcium ion binding |
| Process |
| metabolic process |
| cellular metabolic process |
| serine family amino acid metabolic process |
| l-serine metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| l-serine biosynthetic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine and Serine Metabolism |    |  | | L-serine biosynthesis | Not Available | Not Available | | Glycine, serine and threonine metabolism | Not Available | | | Dimethylglycine Dehydrogenase Deficiency |    | Not Available | | Dihydropyrimidine Dehydrogenase Deficiency (DHPD) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p11.2 |
| SNPs
| PSPH |
| Gene Sequence
|
>678 bp
ATGGTCTCCCACTCAGAGCTGAGGAAGCTTTTCTACTCAGCAGATGCTGTGTGTTTTGAT
GTTGACAGCACGGTCATCAGAGAAGAAGGAATCGATGAGCTAGCCAAAATCTGTGGCGTT
GAGGACGCGGTGTCAGAAATGACACGGCGAGCCATGGGCGGGGCAGTGCCTTTCAAAGCT
GCTCTCACAGAGCGCTTAGCCCTCATCCAGCCCTCCAGGGAGCAGGTGCAGAGACTCATA
GCAGAGCAACCCCCACACCTGACCCCCGGCATAAGGGAGCTGGTAAGTCGCCTACAGGAG
CGAAATGTTCAGGTTTTCCTAATATCTGGTGGCTTTAGGAGTATTGTAGAGCATGTTGCT
TCAAAGCTCAATATCCCAGCAACCAATGTATTTGCCAATAGGCTGAAATTCTACTTTAAC
GGTGAATATGCAGGTTTTGATGAGACGCAGCCAACAGCTGAATCTGGTGGAAAAGGAAAA
GTGATTAAACTTTTAAAGGAAAAATTTCATTTTAAGAAAATAATCATGATTGGAGATGGT
GCCACAGATATGGAAGCCTGTCCTCCTGCTGATGCTTTCATTGGATTTGGAGGAAATGTG
ATCAGGCAACAAGTCAAGGATAACGCCAAATGGTATATCACTGATTTTGTAGAGCTGCTG
GGAGAACTGGAAGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 225 |
| Molecular Weight
| 25007.49 |
| Theoretical pI
| 5.694 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphoserine phosphatase
MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKA
ALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVA
SKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDG
ATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE
|
| External Links |
|---|
| GenBank ID Protein
| 1890331 |
| UniProtKB/Swiss-Prot ID
| P78330 |
| UniProtKB/Swiss-Prot Entry Name
| SERB_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Y10275 |
| GeneCard ID
| PSPH |
| GenAtlas ID
| PSPH |
| HGNC ID
| HGNC:9577 |
| References |
|---|
| General References
| Not Available |