| Identification |
|---|
| HMDB Protein ID
| CDBP03949 |
| Secondary Accession Numbers
| Not Available |
| Name
| ATP-sensitive inward rectifier potassium channel 15 |
| Description
| Not Available |
| Synonyms
|
- Inward rectifier K(+) channel Kir1.3
- Inward rectifier K(+) channel Kir4.2
- Potassium channel, inwardly rectifying subfamily J member 15
|
| Gene Name
| KCNJ15 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in inward rectifier potassium channel activity |
| Specific Function
| Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| inward rectifier potassium channel activity |
| cation channel activity |
| potassium channel activity |
| voltage-gated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.2 |
| SNPs
| KCNJ15 |
| Gene Sequence
|
>1128 bp
ATGGATGCCATTCACATCGGCATGTCCAGCACCCCCCTGGTGAAGCACACTGCTGGGGCT
GGGCTCAAGGCCAACAGACCCCGCGTCATGTCCAAGAGTGGGCACAGCAACGTGAGAATT
GACAAAGTGGATGGCATATACCTACTCTACCTGCAAGACCTGTGGACCACAGTTATCGAC
ATGAAGTGGAGATACAAACTCACCCTGTTCGCTGCCACTTTTGTGATGACCTGGTTCCTT
TTTGGAGTCATCTACTATGCCATCGCGTTTATTCATGGGGACTTAGAACCCGGTGAGCCC
ATTTCAAATCATACCCCCTGCATCATGAAAGTGGACTCTCTCACTGGGGCGTTTCTCTTT
TCCCTGGAATCCCAGACAACCATTGGCTATGGAGTCCGTTCCATCACAGAGGAATGTCCT
CATGCCATCTTCCTGTTGGTTGCTCAGTTGGTCATCACGACCTTGATTGAGATCTTCATC
ACCGGAACCTTCCTGGCCAAAATCGCCAGACCCAAAAAGCGGGCTGAGACCATCAAGTTC
AGCCACTGTGCAGTCATCACCAAGCAGAATGGGAAGCTGTGCTTGGTGATTCAGGTAGCC
AATATGAGGAAGAGCCTCTTGATTCAGTGCCAGCTCTCTGGCAAGCTCCTGCAGACCCAC
GTCACCAAGGAGGGGGAGCGGATTCTCCTCAACCAAGCCACTGTCAAATTCCACGTGGAC
TCCTCCTCTGAGAGCCCCTTCCTCATTCTGCCCATGACATTCTACCATGTGCTGGATGAG
ACGAGCCCCCTGAGAGACCTCACACCCCAAAACCTAAAGGAGAAGGAGTTTGAGCTTGTG
GTCCTCCTCAATGCCACTGTGGAATCCACCAGCGCTGTCTGCCAGAGCCGAACATCTTAT
ATCCCAGAGGAAATCTACTGGGGTTTTGAGTTTGTGCCTGTGGTATCTCTCTCCAAAAAT
GGAAAATATGTGGCTGATTTCAGTCAGTTTGAACAGATTCGGAAAAGCCCAGATTGCACA
TTTTACTGTGCAGATTCTGAGAAACAGCAACTCGAGGAGAAGTACAGGCAGGAGGATCAG
AGGGAAAGAGAACTGAGGACACTTTTATTACAACAGAGCAATGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 375 |
| Molecular Weight
| 42577.0 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ATP-sensitive inward rectifier potassium channel 15
MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVID
MKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLF
SLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKF
SHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD
SSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSY
IPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQ
RERELRTLLLQQSNV
|
| External Links |
|---|
| GenBank ID Protein
| 15426450 |
| UniProtKB/Swiss-Prot ID
| Q99712 |
| UniProtKB/Swiss-Prot Entry Name
| IRK15_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC013327 |
| GeneCard ID
| KCNJ15 |
| GenAtlas ID
| KCNJ15 |
| HGNC ID
| HGNC:6261 |
| References |
|---|
| General References
| Not Available |