| Identification |
|---|
| HMDB Protein ID
| CDBP02291 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytosolic 5'-nucleotidase 3 |
| Description
| Not Available |
| Synonyms
|
- Cytosolic 5'-nucleotidase III
- P5'N-1
- P5N-1
- PN-I
- Pyrimidine 5'-nucleotidase 1
- Uridine 5'-monophosphate hydrolase 1
- cN-III
- p36
|
| Gene Name
| NT5C3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| Can act both as nucleotidase and as phosphotransferase.
|
| GO Classification
|
| Biological Process |
| adenosine metabolic process |
| pyrimidine nucleobase metabolic process |
| pyrimidine nucleoside catabolic process |
| nucleotide metabolic process |
| Cellular Component |
| cytosol |
| endoplasmic reticulum |
| mitochondrion |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| binding |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| nucleotidase activity |
| 5'-nucleotidase activity |
| magnesium ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| Molecular Function |
| 5'-nucleotidase activity |
| magnesium ion binding |
| 2'-phosphotransferase activity |
| nucleotide binding |
|
| Cellular Location
|
- Isoform 2:Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p14.3 |
| SNPs
| NT5C3 |
| Gene Sequence
|
>1011 bp
ATGAGGGCCCCGTCCATGGACCGCGCGGCCGTGGCGAGGGTGGGCGCGGTAGCGAGCGCC
AGCGTGTGCGCCCTGGTGGCGGGGGTGGTGCTGGCTCAGTACATATTCACCTTGAAGAGG
AAGACGGGGCGGAAGACCAAGATCATCGAGATGATGCCAGAATTCCAGAAAAGTTCAGTT
CGAATCAAGAACCCTACAAGAGTAGAAGAAATTATCTGTGGTCTTATCAAAGGAGGAGCT
GCCAAACTTCAGATAATAACGGACTTTGATATGACACTCAGTAGATTTTCATATAAAGGG
AAAAGATGCCCAACATGTCATAATATCATTGACAACTGTAAGCTGGTTACAGATGAATGT
AGAAAAAAGTTATTGCAACTAAAGGAAAAATATTACGCTATTGAAGTTGATCCTGTTCTT
ACTGTAGAAGAGAAGTACCCTTATATGGTGGAATGGTATACTAAATCACATGGTTTGCTT
GTTCAGCAAGCTTTACCAAAAGCTAAACTTAAAGAAATTGTGGCAGAATCTGACGTTATG
CTCAAAGAAGGATATGAGAATTTCTTTGATAAGCTCCAACAACATAGCATCCCCGTGTTC
ATATTTTCGGCTGGAATCGGCGATGTACTAGAGGAAGTTATTCGTCAAGCTGGTGTTTAT
CATCCCAATGTCAAAGTTGTGTCCAATTTTATGGATTTTGATGAAACTGGGGTGCTCAAA
GGATTTAAAGGAGAACTAATTCATGTATTTAACAAACATGATGGTGCCTTGAGGAATACA
GAATATTTCAATCAACTAAAAGACAATAGTAACATAATTCTTCTGGGAGACTCCCAAGGA
GACTTAAGAATGGCAGATGGAGTGGCCAATGTTGAGCACATTCTGAAAATTGGATATCTA
AATGATAGAGTGGATGAGCTTTTAGAAAAGTACATGGACTCTTATGATATTGTTTTAGTA
CAAGATGAATCATTAGAAGTAGCCAACTCTATTTTACAGAAGATTCTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 33914.91 |
| Theoretical pI
| 5.854 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytosolic 5'-nucleotidase 3
MRAPSMDRAAVARVGAVASASVCALVAGVVLAQYIFTLKRKTGRKTKIIEMMPEFQKSSV
RIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYKGKRCPTCHNIIDNCKLVTDEC
RKKLLQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSHGLLVQQALPKAKLKEIVAESDVM
LKEGYENFFDKLQQHSIPVFIFSAGIGDVLEEVIRQAGVYHPNVKVVSNFMDFDETGVLK
GFKGELIHVFNKHDGALRNTEYFNQLKDNSNIILLGDSQGDLRMADGVANVEHILKIGYL
NDRVDELLEKYMDSYDIVLVQDESLEVANSILQKIL
|
| External Links |
|---|
| GenBank ID Protein
| 70608082 |
| UniProtKB/Swiss-Prot ID
| Q9H0P0 |
| UniProtKB/Swiss-Prot Entry Name
| 5NT3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001002010.1 |
| GeneCard ID
| NT5C3 |
| GenAtlas ID
| NT5C3 |
| HGNC ID
| HGNC:17820 |
| References |
|---|
| General References
| Not Available |