| Identification |
|---|
| HMDB Protein ID
| CDBP00717 |
| Secondary Accession Numbers
| Not Available |
| Name
| CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| Description
| Not Available |
| Synonyms
|
- PI synthase
- Phosphatidylinositol synthase
- PtdIns synthase
|
| Gene Name
| CDIPT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, for other substituted phosphate groups |
| Specific Function
| Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| CDP-diacylglycerol metabolic process |
| phosphatidylinositol biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, for other substituted phosphate groups |
| catalytic activity |
| transferase activity |
| Molecular Function |
| manganese ion binding |
| alcohol binding |
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity |
| diacylglycerol binding |
| Process |
| metabolic process |
| phospholipid biosynthetic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Cell membrane
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi- pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phosphatidylinositol Phosphate Metabolism |    |  | | Phospholipid Biosynthesis |    |  | | Glycerophospholipid metabolism | Not Available | | | Phosphatidylinositol signaling system | Not Available |  | | Joubert syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p11.2 |
| SNPs
| CDIPT |
| Gene Sequence
|
>642 bp
ATGCCAGACGAAAATATCTTCCTGTTCGTGCCCAACCTCATCGGTTATGCCCGGATTGTC
TTCGCCATCATTTCTTTCTACTTCATGCCCTGCTGCCCCCTCACGGCCTCCTCCTTCTAC
CTGCTCAGCGGCCTGCTGGACGCTTTCGATGGACACGCTGCTCGCGCTCTTAATCAAGGA
ACCCGGTTTGGGGCCATGCTGGACATGCTGACGGACCGCTGCTCCACCATGTGCCTGTTG
GTCAACCTGGCCCTGCTGTACCCTGGAGCCACGCTGTTCTTCCAAATCAGCATGAGTTTG
GATGTGGCCAGTCACTGGCTGCACCTCCACAGTTCTGTGGTCCGAGGCAGTGAGAGTCAC
AAGATGATCGACTTGTCCGGGAATCCGGTGCTTCGGATCTACTACACCTCGAGGCCTGCT
CTGTTCACCTTGTGTGCTGGGAATGAGCTCTTCTACTGCCTCCTCTACCTGTTCCATTTC
TCTGAGGGACCTTTAGTTGGCTCTGTGGGACTGTTCCGGATGGGCCTCTGGGTCACTGCC
CCCATCGCCTTGCTGAAGTCGCTCATCAGCGTCATCCACCTGATCACGGCCGCCCGCAAC
ATGGCTGCCCTGGACGCAGCAGACCGCGCCAAGAAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 213 |
| Molecular Weight
| 23538.47 |
| Theoretical pI
| 8.037 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>CDP-diacylglycerol--inositol 3-phosphatidyltransferase
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQG
TRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESH
KMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTA
PIALLKSLISVIHLITAARNMAALDAADRAKKK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O14735 |
| UniProtKB/Swiss-Prot Entry Name
| CDIPT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF014807 |
| GeneCard ID
| CDIPT |
| GenAtlas ID
| CDIPT |
| HGNC ID
| HGNC:1769 |
| References |
|---|
| General References
| Not Available |