Identification |
HMDB Protein ID
| CDBP00991 |
Secondary Accession Numbers
| Not Available |
Name
| UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 |
Description
| Not Available |
Synonyms
|
- Beta-1,3-GalNAc-T1
- Beta-1,3-GalTase 3
- Beta-1,3-galactosyltransferase 3
- Beta-3-Gx-T3
- Beta3Gal-T3
- Beta3GalT3
- Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
- Globoside synthase
- UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
- b3Gal-T3
|
Gene Name
| B3GALNT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in galactosyltransferase activity |
Specific Function
| Transfers N-acetylgalactosamine onto globotriaosylceramide.
|
GO Classification
|
Biological Process |
oligosaccharide biosynthetic process |
protein glycosylation |
Cellular Component |
integral to membrane |
Golgi membrane |
Component |
membrane |
cell part |
Function |
galactosyltransferase activity |
catalytic activity |
transferase activity |
transferase activity, transferring hexosyl groups |
transferase activity, transferring glycosyl groups |
Molecular Function |
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity |
Process |
metabolic process |
macromolecule metabolic process |
macromolecule modification |
protein modification process |
protein amino acid glycosylation |
|
Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | Glycosphingolipid biosynthesis - globo series | Not Available | |
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3q25 |
SNPs
| B3GALNT1 |
Gene Sequence
|
>996 bp
ATGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAATGG
AGCCTCCTGCTGCTGTCACTCCTGAGTTTCTTTGTGATGTGGTACCTCAGCCTTCCCCAC
TACAATGTGATAGAACGCGTGAACTGGATGTACTTCTATGAGTATGAGCCGATTTACAGA
CAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTTCTG
GTCATTCTGGTGACCTCCCACCCTTCAGATGTGAAAGCCAGGCAGGCCATTAGAGTTACT
TGGGGTGAAAAAAAGTCTTGGTGGGGATATGAGGTTCTTACATTTTTCTTATTAGGCCAA
GAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTTTAT
GGTGACATAATCCGACAAGATTTTTTAGACACATATAATAACCTGACCTTGAAAACCATT
ATGGCATTCAGGTGGGTAACTGAGTTTTGCCCCAATGCCAAGTACGTAATGAAGACAGAC
ACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCACTCA
GAGAAGTTTTTCACAGGTTATCCTCTAATTGATAATTATTCCTATAGAGGATTTTACCAA
AAAACCCATATTTCTTACCAGGAGTATCCTTTCAAGGTGTTCCCTCCATACTGCAGTGGG
TTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCACGTA
AAACCCATCAAGTTTGAAGATGTTTATGTCGGGATCTGTTTGAATTTATTAAAAGTGAAC
ATTCATATTCCAGAAGACACAAATCTTTTCTTTCTATATAGAATCCATTTGGATGTCTGT
CAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTTTGG
CAGGTCATGCTAAGGAACACCACATGCCATTATTAA
|
Protein Properties |
Number of Residues
| 331 |
Molecular Weight
| 39511.55 |
Theoretical pI
| 7.799 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
MASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYR
QDFHFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQ
EAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYNNLTLKTIMAFRWVTEFCPNAKYVMKTD
TDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSG
LGYIMSRDLVPRIYEMMGHVKPIKFEDVYVGICLNLLKVNIHIPEDTNLFFLYRIHLDVC
QLRRVIAAHGFSSKEIITFWQVMLRNTTCHY
|
External Links |
GenBank ID Protein
| 3256005 |
UniProtKB/Swiss-Prot ID
| O75752 |
UniProtKB/Swiss-Prot Entry Name
| B3GL1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| Y15062 |
GeneCard ID
| B3GALNT1 |
GenAtlas ID
| B3GALNT1 |
HGNC ID
| HGNC:918 |
References |
General References
| Not Available |