| Identification |
|---|
| HMDB Protein ID
| CDBP01429 |
| Secondary Accession Numbers
| Not Available |
| Name
| Isopentenyl-diphosphate Delta-isomerase 1 |
| Description
| Not Available |
| Synonyms
|
- IPP isomerase 1
- IPPI1
- Isopentenyl pyrophosphate isomerase 1
|
| Gene Name
| IDI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in isopentenyl-diphosphate delta-isomerase activity |
| Specific Function
| Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
|
| GO Classification
|
| Biological Process |
| isoprenoid biosynthetic process |
| cholesterol biosynthetic process |
| dimethylallyl diphosphate biosynthetic process |
| response to stilbenoid |
| Cellular Component |
| cytosol |
| mitochondrion |
| peroxisome |
| Function |
| isomerase activity |
| intramolecular oxidoreductase activity |
| catalytic activity |
| hydrolase activity |
| intramolecular oxidoreductase activity, transposing c=c bonds |
| isopentenyl-diphosphate delta-isomerase activity |
| Molecular Function |
| manganese ion binding |
| magnesium ion binding |
| metal ion binding |
| isopentenyl-diphosphate delta-isomerase activity |
| hydrolase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| cellular lipid metabolic process |
| isoprenoid metabolic process |
| isoprenoid biosynthetic process |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | dimethylallyl diphosphate biosynthesis | Not Available | Not Available | | Terpenoid backbone biosynthesis | Not Available |  | | Steroid Biosynthesis |    |  | | Smith-Lemli-Opitz Syndrome (SLOS) |    | Not Available | | CHILD Syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p15.3 |
| SNPs
| IDI1 |
| Gene Sequence
|
>687 bp
ATGATGCCTGAAATAAACACTAACCACCTCGACAAGCAACAGGTTCAACTCCTGGCAGAG
ATGTGTATCCTTATTGATGAAAATGACAATAAAATTGGAGCTGAGACCAAGAAGAATTGT
CACCTGAACGAGAACATTGAGAAAGGATTATTGCATCGAGCTTTTAGTGTCTTCTTATTC
AACACCGAAAATAAGCTTCTGCTACAGCAAAGATCAGATGCTAAGATTACCTTTCCAGGT
TGTTTTACGAATACGTGTTGTAGTCATCCATTAAGCAATCCAGCCGAGCTTGAGGAAAGT
GACGCCCTTGGAGTGAGGCGAGCAGCACAGAGACGGCTGAAAGCTGAGCTAGGAATTCCC
TTGGAAGAGGTTCCTCCAGAAGAAATTAATTATTTAACACGAATTCACTACAAAGCTCAG
TCTGATGGTATCTGGGGTGAACATGAAATTGATTACATTTTGTTGGTGAGGAAGAATGTA
ACTTTGAATCCAGATCCCAATGAGATTAAAAGCTATTGTTATGTGTCAAAGGAAGAACTA
AAAGAACTTCTGAAAAAAGCAGCCAGTGGTGAAATTAAGATAACGCCATGGTTTAAAATT
ATTGCAGCGACTTTTCTCTTTAAATGGTGGGATAACTTAAATCATTTGAATCAGTTTGTT
GACCATGAGAAAATATACAGAATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 32485.165 |
| Theoretical pI
| 7.89 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isopentenyl-diphosphate Delta-isomerase 1
MPEINTNHLDKQQVQLLAEMCILIDENDNKIGAETKKNCHLNENIEKGLLHRAFSVFLFN
TENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELEESDALGVRRAAQRRLKAELGIPL
EEVPPEEINYLTRIHYKAQSDGIWGEHEIDYILLVRKNVTLNPDPNEIKSYCYVSKEELK
ELLKKAASGEIKITPWFKIIAATFLFKWWDNLNHLNQFVDHEKIYRM
|
| External Links |
|---|
| GenBank ID Protein
| 13925759 |
| UniProtKB/Swiss-Prot ID
| Q13907 |
| UniProtKB/Swiss-Prot Entry Name
| IDI1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF271720 |
| GeneCard ID
| IDI1 |
| GenAtlas ID
| IDI1 |
| HGNC ID
| HGNC:5387 |
| References |
|---|
| General References
| Not Available |