Identification |
HMDB Protein ID
| CDBP00802 |
Secondary Accession Numbers
| Not Available |
Name
| NADP-dependent malic enzyme |
Description
| Not Available |
Synonyms
|
- Malic enzyme 1
- NADP-ME
|
Gene Name
| ME1 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in oxidoreductase activity |
Specific Function
| Not Available |
GO Classification
|
Biological Process |
response to hormone stimulus |
malate metabolic process |
protein tetramerization |
response to carbohydrate stimulus |
NADP biosynthetic process |
cellular lipid metabolic process |
carbohydrate metabolic process |
Cellular Component |
cytosol |
mitochondrion |
Function |
binding |
nucleotide binding |
catalytic activity |
nad or nadh binding |
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
oxidoreductase activity, acting on ch-oh group of donors |
oxidoreductase activity |
malate dehydrogenase activity |
malic enzyme activity |
ion binding |
cation binding |
metal ion binding |
Molecular Function |
electron carrier activity |
NAD binding |
manganese ion binding |
NADP binding |
malate dehydrogenase (oxaloacetate-decarboxylating) activity |
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity |
ADP binding |
Process |
metabolic process |
cellular metabolic process |
organic acid metabolic process |
oxoacid metabolic process |
carboxylic acid metabolic process |
oxidation reduction |
dicarboxylic acid metabolic process |
malate metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Transfer of Acetyl Groups into Mitochondria | | Not Available | PPAR signaling pathway | Not Available | | Pyruvate Metabolism | | | Leigh Syndrome | | Not Available | Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) | | Not Available |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6q12 |
SNPs
| ME1 |
Gene Sequence
|
>1719 bp
ATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGG
AACCCTCACCTCAACAAGGACTTGGCCTTTACCCTGGAAGAGAGACAGCAATTGAACATT
CATGGATTGTTGCCACCTTCCTTCAACAGTCAGGAGATCCAGGTTCTTAGAGTAGTAAAA
AATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGAT
AGAAATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATT
GTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCA
AGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGG
CCAGAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAGAGCGTATTCTTGGCTTGGGA
GACCTTGGCTGTAATGGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGC
GGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAG
GAGTTACTTAAAGATCCACTCTACATTGGACTACGGCAGAGAAGAGTAAGAGGTTCTGAA
TATGATGATTTTTTGGACGAATTCATGGAGGCAGTTTCTTCCAAGTATGGCATGAATTGC
CTTATTCAGTTTGAAGATTTTGCCAATGTGAATGCATTTCGTCTCCTGAACAAGTATCGA
AACCAGTATTGCACATTCAATGATGATATTCAAGGAACAGCATCTGTTGCAGTTGCAGGT
CTCCTTGCAGCTCTTCGAATAACCAAGAACAAACTGTCTGATCAAACAATACTATTCCAA
GGAGCTGGAGAGGCTGCCCTAGGGATTGCACACCTGATTGTGATGGCCTTGGAAAAAGAA
GGTTTACCAAAAGAGAAAGCCATCAAAAAGATATGGCTGGTTGATTCAAAAGGATTAATA
GTTAAGGGACGTGCTTCCTTAACACAAGAGAAAGAGAAGTTTGCCCATGAACATGAAGAA
ATGAAGAACCTAGAAGCCATTGTTCAAGAAATAAAACCAACTGCCCTCATAGGAGTTGCT
GCAATTGGTGGTGCATTCTCAGAACAAATTCTCAAAGATATGGCTGCCTTCAATGAACGG
CCTATTATTTTTGCTTTGAGTAATCCAACTAGCAAAGCAGAATGTTCTGCAGAGCAGTGC
TACAAAATAACCAAGGGACGTGCAATTTTTGCCAGTGGCAGTCCTTTTGATCCAGTCACT
CTTCCAAATGGACAGACCCTATATCCTGGCCAAGGCAACAATTCCTACGTGTTCCCTGGA
GTTGCTCTTGGTGTTGTGGCGTGTGGATTGAGGCAGATCACAGATAATATTTTCCTCACT
ACTGCTGAGGTTATAGCTCAGCAAGTGTCAGATAAACACTTGGAAGAGGGTCGGCTTTAT
CCTCCTTTGAATACCATTAGAGATGTTTCTCTGAAAATTGCAGAAAAGATTGTGAAAGAT
GCATACCAAGAAAAGACAGCCACAGTTTATCCTGAACCGCAAAACAAAGAAGCATTTGTC
CGCTCCCAGATGTATAGTACTGATTATGACCAGATTCTACCTGATTGTTATTCTTGGCCT
GAAGAGGTGCAGAAAATACAGACCAAAGTTGACCAGTAG
|
Protein Properties |
Number of Residues
| 572 |
Molecular Weight
| 64149.075 |
Theoretical pI
| 6.126 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>NADP-dependent malic enzyme
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVK
NFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP
RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC
GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNC
LIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ
GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEE
MKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLT
TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV
RSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
|
External Links |
GenBank ID Protein
| 495123 |
UniProtKB/Swiss-Prot ID
| P48163 |
UniProtKB/Swiss-Prot Entry Name
| MAOX_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| X77244 |
GeneCard ID
| ME1 |
GenAtlas ID
| ME1 |
HGNC ID
| HGNC:6983 |
References |
General References
| Not Available |