| Identification |
|---|
| HMDB Protein ID
| CDBP02128 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cholinephosphotransferase 1 |
| Description
| Not Available |
| Synonyms
|
- AAPT1-like protein
- Diacylglycerol cholinephosphotransferase 1
- hCPT1
|
| Gene Name
| CHPT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, for other substituted phosphate groups |
| Specific Function
| Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
|
| GO Classification
|
| Biological Process |
| regulation of cell growth |
| platelet activating factor biosynthetic process |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, for other substituted phosphate groups |
| Molecular Function |
| diacylglycerol binding |
| metal ion binding |
| diacylglycerol cholinephosphotransferase activity |
| Process |
| metabolic process |
| phospholipid biosynthetic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Golgi apparatus membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phospholipid Biosynthesis |    |  | | Glycerophospholipid metabolism | Not Available | | | Ether lipid metabolism | Not Available |  | | Lamivudine Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q |
| SNPs
| CHPT1 |
| Gene Sequence
|
>1221 bp
ATGGCGGCAGGCGCCGGGGCCGGGTCCGCGCCGCGCTGGCTGAGGGCGCTGAGCGAGCCG
CTGAGCGCGGCGCAGCTGCGGCGACTGGAGGAGCACCGCTACAGCGCGGCGGGCGTCTCG
CTGCTCGAGCCGCCGCTGCAGCTCTACTGGACCTGGCTGCTCCAGTGGATCCCGCTCTGG
ATGGCCCCCAACTCCATCACCCTGCTGGGGCTCGCCGTCAACGTGGTCACCACGCTCGTG
CTCATCTCCTACTGTCCCACGGCCACCGAAGAGGCACCATACTGGACATACCTTTTATGT
GCACTGGGACTTTTTATTTACCAGTCACTGGATGCTATTGATGGGAAACAAGCCAGAAGA
ACAAACTCTTGTTCCCCTTTAGGGGAGCTCTTTGACCATGGCTGTGACTCTCTTTCCACA
GTATTTATGGCAGTGGGAGCTTCAATTGCCGCTCGCTTAGGAACTTATCCTGACTGGTTT
TTTTTCTGCTCTTTTATTGGGATGTTTGTGTTTTATTGCGCTCATTGGCAGACTTATGTT
TCAGGCATGTTGAGATTTGGAAAAGTGGATGTAACTGAAATTCAGATAGCTTTAGTGATT
GTCTTTGTGTTGTCTGCATTTGGAGGAGCAACAATGTGGGACTATACGATTCCTATTCTA
GAAATAAAATTGAAGATCCTTCCAGTTCTTGGATTTCTAGGTGGAGTAATATTTTCCTGT
TCAAATTATTTCCATGTTATCCTCCATGGTGGTGTTGGCAAGAATGGATCCACTATAGCA
GGCACCAGTGTCTTGTCACCTGGACTCCACATAGGACTAATTATTATACTGGCAATAATG
ATCTATAAAAAGTCAGCAACTGATGTGTTTGAAAAGCATCCTTGTCTTTATATCCTAATG
TTTGGATGTGTCTTTGCTAAAGTCTCACAAAAATTAGTGGTAGCTCACATGACCAAAAGT
GAACTATATCTTCAAGACACTGTCTTTTTGGGGCCAGGTCTTTTGTTTTTAGACCAGTAC
TTTAATAACTTTATAGACGAATATGTTGTTCTATGGATGGCAATGGTGATTTCTTCATTT
GATATGGTGATATACTTTAGTGCTTTGTGCCTGCAAATTTCAAGACACCTTCATCTAAAT
ATATTCAAGACTGCATGTCATCAAGCACCTGAACAGGTTCAAGTTCTTTCTTCAAAGAGT
CATCAGAATAACATGGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 45096.535 |
| Theoretical pI
| 6.92 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cholinephosphotransferase 1
MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLW
MAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARR
TNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYV
SGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSC
SNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILM
FGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSF
DMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD
|
| External Links |
|---|
| GenBank ID Protein
| 50726996 |
| UniProtKB/Swiss-Prot ID
| Q8WUD6 |
| UniProtKB/Swiss-Prot Entry Name
| CHPT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020244.2 |
| GeneCard ID
| CHPT1 |
| GenAtlas ID
| CHPT1 |
| HGNC ID
| HGNC:17852 |
| References |
|---|
| General References
| Not Available |