Identification |
HMDB Protein ID
| CDBP00329 |
Secondary Accession Numbers
| Not Available |
Name
| Nicotinamide mononucleotide adenylyltransferase 1 |
Description
| Not Available |
Synonyms
|
- NMN adenylyltransferase 1
- NaMN adenylyltransferase 1
- Nicotinate-nucleotide adenylyltransferase 1
- SubName: Nicotinamide nucleotide adenylyltransferase 1, isoform CRA_a
- SubName: cDNA, FLJ96727, Homo sapiens nicotinamide nucleotide adenylyltransferase 1(NMNAT1), mRNA
|
Gene Name
| NMNAT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotidyltransferase activity |
Specific Function
| Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
|
GO Classification
|
Biological Process |
NAD biosynthetic process |
water-soluble vitamin metabolic process |
Cellular Component |
nucleoplasm |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
nucleotidyltransferase activity |
Molecular Function |
ATP binding |
nicotinamide-nucleotide adenylyltransferase activity |
nicotinate-nucleotide adenylyltransferase activity |
Process |
coenzyme biosynthetic process |
pyridine nucleotide biosynthetic process |
nicotinamide nucleotide biosynthetic process |
nad biosynthetic process |
cellular metabolic process |
biosynthetic process |
cofactor metabolic process |
coenzyme metabolic process |
metabolic process |
|
Cellular Location
|
- Nucleus
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | NAD(+) biosynthesis | Not Available | Not Available |
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1p36.22 |
SNPs
| NMNAT1 |
Gene Sequence
|
>840 bp
ATGGAAAATTCCGAGAAGACTGAAGTGGTTCTCCTTGCTTGTGGTTCATTCAATCCCATC
ACCAACATGCACCTCAGGTTGTTTGAGCTGGCCAAGGACTACATGAATGGAACAGGAAGG
TACACAGTTGTCAAAGGCATCATCTCTCCTGTTGGTGATGCCTACAAGAAGAAAGGACTC
ATTCCTGCCTATCACCGGGTCATCATGGCAGAACTTGCTACCAAGAATTCTAAATGGGTG
GAAGTTGATACATGGGAAAGTCTTCAGAAGGAGTGGAAAGAGACTCTGAAGGTGCTAAGA
CACCATCAAGAGAAATTGGAGGCTAGTGACTGTGATCACCAGCAGAACTCACCTACTCTA
GAAAGGCCTGGAAGGAAGAGGAAGTGGACTGAAACACAAGATTCTAGTCAAAAGAAATCC
CTAGAGCCAAAAACAAAAGCTGTGCCAAAGGTCAAGCTGCTGTGTGGGGCAGATTTATTG
GAGTCCTTTGCTGTTCCCAATTTGTGGAAGAGTGAAGACATCACCCAAATCGTGGCCAAC
TATGGGCTCATATGTGTTACTCGGGCTGGAAATGATGCTCAGAAGTTTATCTATGAATCG
GATGTGCTGTGGAAACACCGGAGCAACATTCACGTGGTGAATGAATGGATCGCTAATGAC
ATCTCATCCACAAAAATCCGGAGAGCCCTCAGAAGGGGCCAGAGCATTCGCTACTTGGTA
CCAGATCTTGTCCAAGAATACATTGAAAAGCATAATTTGTACAGCTCTGAGAGTGAAGAC
AGGAATGCTGGGGTCATCCTGGCCCCTTTGCAGAGAAACACTGCAGAAGCTAAGACATAG
|
Protein Properties |
Number of Residues
| 279 |
Molecular Weight
| 31932.22 |
Theoretical pI
| 8.86 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Nicotinamide mononucleotide adenylyltransferase 1
MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGL
IPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPTL
ERPGRKRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVAN
YGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLV
PDLVQEYIEKHNLYSSESEDRNAGVILAPLQRNTAEAKT
|
External Links |
GenBank ID Protein
| 189055023 |
UniProtKB/Swiss-Prot ID
| Q9HAN9 |
UniProtKB/Swiss-Prot Entry Name
| NMNA1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF314163 |
GeneCard ID
| NMNAT1 |
GenAtlas ID
| NMNAT1 |
HGNC ID
| HGNC:17877 |
References |
General References
| Not Available |