Cannabis Compound Database: Showing Protein Ribose-phosphate pyrophosphokinase 3 (CDBP00537)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00537

Secondary Accession Numbers

Not Available

Name

Ribose-phosphate pyrophosphokinase 3

Description

Not Available

Synonyms

PRPS1-like 1
PRS-III
Phosphoribosyl pyrophosphate synthase 1-like 1
Phosphoribosyl pyrophosphate synthase III

Gene Name

PRPS1L1

Protein Type

Enzyme

Biological Properties

General Function

Involved in magnesium ion binding

Specific Function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

GO Classification

Biological Process
nucleotide biosynthetic process
5-phosphoribose 1-diphosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
nucleoside metabolic process
Function
magnesium ion binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
diphosphotransferase activity
ribose phosphate diphosphokinase activity
Molecular Function
magnesium ion binding
kinase activity
ribose phosphate diphosphokinase activity
ATP binding
protein homodimerization activity
Process
ribonucleoside monophosphate biosynthetic process
nucleoside metabolic process
biosynthetic process
cellular biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
5-phospho-alpha-D-ribose 1-diphosphate biosynthesis	Not Available	Not Available
Pentose Phosphate Pathway
Glucose-6-phosphate dehydrogenase deficiency		Not Available
Ribose-5-phosphate isomerase deficiency		Not Available
Transaldolase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

7p21.1

SNPs

PRPS1L1

Gene Sequence

>957 bp
ACGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCCCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACC
TGCGTGGAAATTGATGAGAGTGTGCGTGGAGAGGATGTCTACATCGTTCAGAGTGGTTGT
GGCGAAATCAACGACAGTCTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCTAGCCGAGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGACAGGATAAGAAG
GATAAGAGCCGGTCCCCAATCTCTGCCAAGCTTGTTGCAAATATGCTCTCTATAGCAGGT
GCGGATCATATCATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAACTTGTATGCAGAGCCAACTGTCCTGAAGTGGATAAGGGAGAATATCCCT
GAGTGGAAGAACTGCATTATTGTCTCGCCAGATGCTGGTGGAGCTAAAAGAGTGACCTCC
ATTGCAGACCAGTTGAATGTGGACTTTGCTTTGATTCATAAAGAACGGAAGAAGGCCAAT
GAAGTGGACTGCATAGTGCTAGTGGGAGATGTGAATGATCGTGTGGCTATCCTTGTAGAT
GACATGGCAGACACTTGTGTTACAATCTGCCTCGCAGCTGACAAACTTCTCTCAGCTGGA
GCAACCAGAGTTTATGCTATCTTGACTCATGGAATCTTTTCTGGCCCAGCCATTTCTCGC
ATCAACACTGCATGCTTTGAAGCAGTGGTAGTCACCAATACCATACCTCAAGATGATAAG
ATGAAGCATTGCTCCAAAATACGAGTAATTGACATCTCCATGATCCTTGCAGAAGCCATA
AGGAGAACTCATAATGGGGAATCTGTTTCCTACCTGTTCAGCCATGTTCCTTTATAA

Protein Properties

Number of Residues

318

Molecular Weight

34838.915

Theoretical pI

6.353

Pfam Domain Function

Pribosyltran (PF00156 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ribose-phosphate pyrophosphokinase 3
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGC
GEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTS
IADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAG
ATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAI
RRTHNGESVSYLFSHVPL

External Links

GenBank ID Protein

110611809

UniProtKB/Swiss-Prot ID

P21108

UniProtKB/Swiss-Prot Entry Name

PRPS3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

BC062797

GeneCard ID