Showing Protein Mitogen-activated protein kinase kinase kinase MLK4 (CDBP03965)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03965
Secondary Accession Numbers Not Available
Name Mitogen-activated protein kinase kinase kinase MLK4
Description Not Available
Synonyms
  1. Mixed lineage kinase 4
Gene Name MLK4
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Activates the JUN N-terminal pathway
GO Classification
Function
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs MLK4
Gene Sequence 
>3111 bp
ATGGCTTTGCGGGGCGCCGCGGGAGCGACCGACACCCCGGTGTCCTCGGCCGGGGGAGCC
CCCGGCGGCTCAGCGTCCTCGTCGTCCACCTCCTCGGGCGGCTCGGCCTCGGCGGGCGCG
GGGCTGTGGGCCGCGCTCTATGACTACGAGGCTCGCGGCGAGGACGAGCTGAGCCTGCGG
CGCGGCCAGCTGGTGGAGGTGCTGTCGCAGGACGCCGCCGTGTCGGGCGACGAGGGCTGG
TGGGCAGGCCAGGTGCAGCGGCGCCTCGGCATCTTCCCCGCCAACTACGTGGCTCCCTGC
CGCCCGGCCGCCAGCCCCGCGCCGCCGCCCTCGCGGCCCAGCTCCCCGGTACACGTCGCC
TTCGAGCGGCTGGAGCTGAAGGAGCTCATCGGCGCTGGGGGCTTCGGGCAGGTGTACCGC
GCCACCTGGCAGGGCCAGGAGGTGGCCGTGAAGGCGGCGCGCCAGGACCCGGAGCAGGAC
GCGGCGGCGGCTGCCGAGAGCGTGCGGCGCGAGGCTCGGCTCTTCGCCATGCTGCGGCAC
CCCAACATCATCGAGCTGCGCGGCGTGTGCCTGCAGCAGCCGCACCTCTGCCTGGTGCTG
GAGTTCGCCCGCGGCGGAGCGCTCAACCGAGCGCTGGCCGCTGCCAACGCCGCCCCGGAC
CCGCGCGCGCCCGGCCCCCGCCGCGCGCGCCGCATCCCTCCGCACGTGCTGGTCAACTGG
GCCGTGCAGATAGCGCGGGGCATGCTCTACCTGCATGAGGAGGCCTTCGTGCCCATCCTG
CACCGGGACCTCAAGTCCAGCAACATTTTGCTACTTGAGAAGATAGAACATGATGACATC
TGCAATAAAACTTTGAAGATTACAGATTTTGGGTTGGCGAGGGAATGGCACAGGACCACC
AAAATGAGCACAGCAGGCACCTATGCCTGGATGGCCCCCGAAGTGATCAAGTCTTCCTTG
TTTTCTAAGGGAAGCGACATCTGGAGCTATGGAGTGCTGCTGTGGGAACTGCTCACCGGA
GAAGTCCCCTATCGGGGCATTGATGGCCTCGCCGTGGCTTATGGGGTAGCAGTCAATAAA
CTCACTTTGCCCATTCCATCCACCTGCCCTGAGCCGTTTGCCAAGCTCATGAAAGAATGC
TGGCAACAAGACCCTCATATTCGTCCATCGTTTGCCTTAATTCTCGAACAGTTGACTGCT
ATTGAAGGGGCAGTGATGACTGAGATGCCTCAAGAATCTTTTCATTCCATGCAAGATGAC
TGGAAACTAGAAATTCAACAAATGTTTGATGAGTTGAGAACAAAGGAAAAGGAGCTGCGA
TCCCGGGAAGAGGAGCTGACTCGGGCGGCTCTGCAGCAGAAGTCTCAGGAGGAGCTGCTA
AAGCGGCGTGAGCAGCAGCTGGCAGAGCGCGAGATCGACGTGCTGGAGCGGGAACTTAAC
ATTCTGATATTCCAGCTAAACCAGGAGAAGCCCAAGGTAAAGAAGAGGAAGGGCAAGTTT
AAGAGAAGTCGTTTAAAGCTCAAAGATGGACATCGAATCAGTTTACCTTCAGATTTCCAG
CACAAGATAACCGTGCAGGCCTCTCCCAACTTGGACAAACGGCGGAGCCTGAACAGCAGC
AGTTCCAGTCCCCCGAGCAGCCCCACAATGATGCCCCGACTCCGAGCCATACAGTTGACT
TCAGATGAAAGCAATAAAACTTGGGGAAGGAACACAGTCTTTCGACAAGAAGAATTTGAG
GATGTAAAAAGGAATTTTAAGAAAAAAGGTTGTACCTGGGGACCAAATTCCATTCAAATG
AAAGATAGAACAGATTGCAAAGAAAGGATAAGACCTCTCTCCGATGGCAACAGTCCTTGG
TCAACTATCTTAATAAAAAATCAGAAAACCATGCCCTTGGCTTCATTGTTTGTGGACCAG
CCAGGGTCCTGTGAAGAGCCAAAACTTTCCCCTGATGGATTAGAACACAGAAAACCAAAA
CAAATAAAATTGCCTAGTCAGGCCTACATTGATCTACCTCTTGGGAAAGATGCTCAGAGA
GAGAATCCTGCAGAAGCTGAAAGCTGGGAGGAGGCAGCCTCTGCGAATGCTGCCACAGTC
TCCATTGAGATGACTCCTACGAATAGTCTGAGTAGATCCCCCCAGAGAAAGAAAACGGAG
TCAGCTCTGTATGGGTGCACCGTCCTTCTGGCATCGGTGGCTCTGGGACTGGACCTCAGA
GAGCTTCATAAAGCACAGGCTGCTGAAGAACCGTTGCCCAAGGAAGAGAAGAAGAAACGA
GAGGGAATCTTCCAGCGGGCTTCCAAGTCCCGCAGAAGCGCCAGTCCTCCCACAAGCCTG
CCATCCACCTGTGGGGAGGCCAGCAGCCCACCCTCCCTGCCACTGTCAAGTGCCCTGGGC
ATCCTCTCCACACCTTCTTTCTCCACAAAGTGCCTGCTGCAGATGGACAGTGAAGATCCA
CTGGTGGACAGTGCACCTGTCACTTGTGACTCTGAGATGCTCACTCCGGATTTTTGTCCC
ACTGCCCCAGGAAGTGGTCGTGAGCCAGCCCTCATGCCAAGACTTGACACTGATTGTAGT
GTATCAAGAAACTTGCCGTCTTCCTTCCTACAGCAGACATGTGGGAATGTACCTTACTGT
GCTTCTTCAAAACATAGACCGTCACATCACAGACGGACCATGTCTGATGGAAATCCGACC
CCAACTGGTGCAACTATTATCTCAGCCACTGGAGCCTCTGCACTGCCACTCTGCCCCTCA
CCTGCTCCTCACAGTCATCTGCCAAGGGAGGTCTCACCCAAGAAGCACAGCACTGTCCAC
ATCGTGCCTCAGCGTCGCCCTGCCTCCCTGAGAAGCCGCTCAGATCTGCCTCAGGCTTAC
CCACAGACAGCAGTGTCTCAGCTGGCACAGACTGCCTGTGTAGTGGGTCGCCCAGGACCA
CATCCCACCCAATTCCTCGCTGCCAAGGAGAGAACTAAATCCCATGTGCCTTCATTACTG
GATGCTGACGTGGAAGGTCAGAGCAGGGACTACACTGTGCCACTGTGCAGAATGAGGAGC
AAAACCAGCCGGCCATCTATATATGAACTGGAGAAAGAATTCCTGTCTTAA
Protein Properties
Number of Residues 1036
Molecular Weight 113955.4
Theoretical pI 8.94
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Mitogen-activated protein kinase kinase kinase MLK4
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
GenBank ID Protein 155723000
UniProtKB/Swiss-Prot ID Q5TCX8
UniProtKB/Swiss-Prot Entry Name M3KL4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_032435.2
GeneCard ID MLK4
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available