Showing Protein Ribose-phosphate pyrophosphokinase 1 (CDBP00595)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 compounds
Identification
HMDB Protein ID CDBP00595
Secondary Accession Numbers Not Available
Name Ribose-phosphate pyrophosphokinase 1
Description Not Available
Synonyms
  1. PPRibP
  2. PRS-I
  3. Phosphoribosyl pyrophosphate synthase I
Gene Name PRPS1
Protein Type Enzyme
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
GO Classification
Biological Process
hypoxanthine biosynthetic process
ribonucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
nervous system development
nucleoside metabolic process
urate biosynthetic process
carbohydrate metabolic process
pyrimidine nucleotide biosynthetic process
5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
cytosol
Function
diphosphotransferase activity
ribose phosphate diphosphokinase activity
magnesium ion binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Molecular Function
magnesium ion binding
kinase activity
ribose phosphate diphosphokinase activity
ATP binding
Process
nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
nucleoside metabolic process
biosynthetic process
cellular biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
nucleoside monophosphate metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location X
Locus Xq21.32-q24
SNPs PRPS1
Gene Sequence 
>957 bp
ATGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCTCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACC
TGTGTGGAAATTGGTGAAAGTGTACGTGGAGAGGATGTCTACATTGTTCAGAGTGGTTGT
GGCGAAATCAATGACAATTTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCCAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGGCAGGATAAGAAA
GATAAGAGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCTGTAGCAGGT
GCAGATCATATTATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAATTTGTATGCAGAGCCGGCTGTCCTAAAGTGGATAAGGGAGAATATCTCT
GAGTGGAGGAACTGCACTATTGTCTCACCTGATGCTGGTGGAGCTAAGAGAGTGACCTCC
ATTGCAGACAGGCTGAATGTGGACTTTGCCTTGATTCACAAAGAACGGAAGAAGGCCAAT
GAAGTGGACCGCATGGTGCTTGTGGGAGATGTGAAGGATCGGGTGGCCATCCTTGTGGAT
GACATGGCTGACACTTGTGGCACAATCTGCCATGCAGCTGACAAACTTCTCTCAGCTGGC
GCCACCAGAGTTTATGCCATCTTGACTCATGGAATCTTCTCCGGTCCTGCTATTTCTCGC
ATCAACAACGCATGCTTTGAGGCAGTAGTAGTCACCAATACCATACCTCAGGAGGACAAG
ATGAAGCATTGCTCCAAAATACAGGTGATTGACATCTCTATGATCCTTGCAGAAGCCATC
AGGAGAACTCACAATGGAGAATCCGTTTCTTACCTATTCAGCCATGTCCCTTTATAA
Protein Properties
Number of Residues 318
Molecular Weight 12324.195
Theoretical pI 6.662
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Ribose-phosphate pyrophosphokinase 1
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGC
GEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTS
IADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAI
RRTHNGESVSYLFSHVPL
GenBank ID Protein 57208781
UniProtKB/Swiss-Prot ID P60891
UniProtKB/Swiss-Prot Entry Name PRPS1_HUMAN
PDB IDs
GenBank Gene ID AL137787
GeneCard ID PRPS1
GenAtlas ID PRPS1
HGNC ID HGNC:9462
References
General References Not Available