Cannabis Compound Database: Showing Protein S-adenosylmethionine synthase isoform type-2 (CDBP00397)

Identification Biological properties Gene properties Protein properties External links References XML Show 9 compounds

Identification

HMDB Protein ID

CDBP00397

Secondary Accession Numbers

Not Available

Name

S-adenosylmethionine synthase isoform type-2

Description

Not Available

Synonyms

AdoMet synthase 2
MAT 2
MAT-II
Methionine adenosyltransferase 2
Methionine adenosyltransferase II

Gene Name

MAT2A

Protein Type

Enzyme

Biological Properties

General Function

Involved in methionine adenosyltransferase activity

Specific Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

GO Classification

Biological Process
response to cAMP
circadian rhythm
cellular nitrogen compound metabolic process
response to hormone stimulus
response to light stimulus
response to drug
sulfur amino acid metabolic process
xenobiotic metabolic process
S-adenosylmethionine biosynthetic process
methanogenesis
methylation
one-carbon metabolic process
Cellular Component
cytosol
Function
binding
catalytic activity
transferase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
methionine adenosyltransferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Molecular Function
metal ion binding
ATP binding
methionine adenosyltransferase activity
Process
metabolic process
cellular metabolic process
one-carbon metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
S-adenosyl-L-methionine biosynthesis	Not Available	Not Available
Cysteine and methionine metabolism	Not Available
Selenoamino Acid Metabolism
Spermidine and Spermine Biosynthesis		Not Available
Methionine Metabolism

Gene Properties

Chromosome Location

Locus

2p11.2

SNPs

MAT2A

Gene Sequence

>1188 bp
ATGAACGGACAGCTCAACGGCTTCCACGAGGCGTTCATCGAGGAGGGCACATTCCTTTTC
ACCTCAGAGTCGGTCGGGGAAGGCCACCCAGATAAGATTTGTGACCAAATCAGTGATGCT
GTCCTTGATGCCCACCTTCAGCAGGATCCTGATGCCAAAGTAGCTTGTGAAACTGTTGCT
AAAACTGGAATGATCCTTCTTGCTGGGGAAATTACATCCAGAGCTGCTGTTGACTACCAG
AAAGTGGTTCGTGAAGCTGTTAAACACATTGGATATGATGATTCTTCCAAAGGTTTTGAC
TACAAGACTTGTAACGTGCTGGTAGCCTTGGAGCAACAGTCACCAGATATTGCTCAAGGT
GTTCATCTTGACAGAAATGAAGAAGACATTGGTGCTGGAGACCAGGGCTTAATGTTTGGC
TATGCCACTGATGAAACTGAGGAGTGTATGCCTTTAACCATTGTCTTGGCACACAAGCTA
AATGCCAAACTGGCAGAACTACGCCGTAATGGCACTTTGCCTTGGTTACGCCCTGATTCT
AAAACTCAAGTTACTGTGCAGTATATGCAGGATCGAGGTGCTGTGCTTCCCATCAGAGTC
CACACAATTGTTATATCTGTTCAGCATGATGAAGAGGTTTGTCTTGATGAAATGAGGGAT
GCCCTAAAGGAGAAAGTCATCAAAGCAGTTGTGCCTGCGAAATACCTTGATGAGGATACA
ATCTACCACCTACAGCCAAGTGGCAGATTTGTTATTGGTGGGCCTCAGGGTGATGCTGGT
TTGACTGGACGGAAAATCATTGTGGACACTTATGGCGGTTGGGGTGCTCATGGAGGAGGT
GCCTTTTCAGGAAAGGATTATACCAAGGTCGACCGTTCAGCTGCTTATGCTGCTCGTTGG
GTGGCAAAATCCCTTGTTAAAGGAGGTCTGTGCCGGAGGGTTCTTGTTCAGGTCTCTTAT
GCTATTGGAGTTTCTCATCCATTATCTATCTCCATTTTCCATTATGGTACCTCTCAGAAG
AGTGAGAGAGAGCTATTAGAGATTGTGAAGAAGAATTTCGATCTCCGCCCTGGGGTCATT
GTCAGGGATCTGGATCTGAAGAAGCCAATTTATCAGAGGACTGCAGCCTATGGCCACTTT
GGTAGGGACAGCTTCCCATGGGAAGTGCCCAAAAAGCTTAAATATTGA

Protein Properties

Number of Residues

395

Molecular Weight

43660.37

Theoretical pI

6.48

Pfam Domain Function

S-AdoMet_synt_C (PF02773 )
S-AdoMet_synt_M (PF02772 )
S-AdoMet_synt_N (PF00438 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>S-adenosylmethionine synthase isoform type-2
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

External Links

GenBank ID Protein

36327

UniProtKB/Swiss-Prot ID

P31153

UniProtKB/Swiss-Prot Entry Name

METK2_HUMAN

PDB IDs