| Identification |
|---|
| HMDB Protein ID
| CDBP01971 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Description
| Not Available |
| Synonyms
|
- PP2A-alpha
- RP-C
- Replication protein C
|
| Gene Name
| PPP2CA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
|
| GO Classification
|
| Biological Process |
| protein heterotrimerization |
| regulation of protein autophosphorylation |
| regulation of DNA replication |
| regulation of protein catabolic process |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| ceramide metabolic process |
| regulation of transcription, DNA-dependent |
| second-messenger-mediated signaling |
| regulation of receptor activity |
| RNA splicing |
| fibroblast growth factor receptor signaling pathway |
| regulation of Wnt receptor signaling pathway |
| protein dephosphorylation |
| induction of apoptosis |
| positive regulation of protein serine/threonine kinase activity |
| mesoderm development |
| negative regulation of cell growth |
| meiosis |
| inactivation of MAPK activity |
| regulation of cell adhesion |
| negative regulation of epithelial to mesenchymal transition |
| negative regulation of tyrosine phosphorylation of Stat3 protein |
| Cellular Component |
| cytosol |
| microtubule cytoskeleton |
| mitochondrion |
| plasma membrane |
| nucleus |
| chromosome, centromeric region |
| membrane |
| protein phosphatase type 2A complex |
| spindle pole |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| phosphoprotein phosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
- Chromosome
- centromere
- spindle pole
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | mRNA surveillance pathway | Not Available |  | | Oocyte meiosis | Not Available |  | | PI3K-Akt signaling pathway | Not Available |  | | TGF-beta signaling pathway | Not Available |  | | Hippo signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q31.1 |
| SNPs
| PPP2CA |
| Gene Sequence
|
>930 bp
ATGGACGAGAAGGTGTTCACCAAGGAGCTGGACCAGTGGATCGAGCAGCTGAACGAGTGC
AAGCAGCTGTCCGAGTCCCAGGTCAAGAGCCTCTGCGAGAAGGCTAAAGAAATCCTGACA
AAAGAATCCAACGTGCAAGAGGTTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGG
CAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTAC
TTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTT
GTAGCTCTTAAGGTTCGTTACCGTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGC
AGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATGGAAATGCA
AATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGAT
GGGCAGATCTTCTGTCTACATGGTGGTCTCTCGCCATCTATAGATACACTGGATCATATC
AGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACTTGCTGTGG
TCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTT
GGGCAAGATATTTCTGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCT
CACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAACGATTTTC
AGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGAT
ACTCTAAAATACTCTTTCTTGCAGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTT
ACTCGTCGTACCCCAGACTACTTCCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35593.93 |
| Theoretical pI
| 5.537 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
|
| External Links |
|---|
| GenBank ID Protein
| 36120 |
| UniProtKB/Swiss-Prot ID
| P67775 |
| UniProtKB/Swiss-Prot Entry Name
| PP2AA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X12646 |
| GeneCard ID
| PPP2CA |
| GenAtlas ID
| PPP2CA |
| HGNC ID
| HGNC:9299 |
| References |
|---|
| General References
| Not Available |