Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase 4 (CDBP01383)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP01383

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase 4

Description

Not Available

Synonyms

MST-1
Mammalian STE20-like protein kinase 1
STE20-like kinase MST1
Serine/threonine-protein kinase Krs-2

Gene Name

STK4

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation

GO Classification

Function
protein binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
biological regulation
regulation of biological process
cellular metabolic process
regulation of cellular process
signal transduction
protein amino acid phosphorylation
phosphorylation

Cellular Location

Nucleus
Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

20q11.2-q13.2

SNPs

STK4

Gene Sequence

>1464 bp
ATGGAGACGGTACAGCTGAGGAACCCGCCGCGCCGGCAGCTGAAAAAGTTGGATGAAGAT
AGTTTAACCAAACAACCAGAAGAAGTATTTGATGTCTTAGAGAAACTTGGAGAAGGGTCC
TATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAA
GTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGT
GACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATC
GTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACG
TTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTAAGGGACTTGAATACCTT
CATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAA
GGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAG
CGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGA
TACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGA
AAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCT
CCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAG
TGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTT
GTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTG
AAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCA
GAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACT
GTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACG
TTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACT
ATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAA
CAAAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGTGTACCTGGTCCACTGAAA
AATTCTTCAGATTGGAAAATACCACAGGATGGAGACTACGAGTTTCTTAAGAGTTGGACA
GTGGAGGACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAA
GAGATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCATCCTGGATGCCATAGAGGCTAAG
AAGAGACGGCAACAAAACTTCTGA

Protein Properties

Number of Residues

487

Molecular Weight

55629.8

Theoretical pI

4.71

Pfam Domain Function

Pkinase (PF00069 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Serine/threonine-protein kinase 4
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF

External Links

GenBank ID Protein

189054830

UniProtKB/Swiss-Prot ID

Q13043

UniProtKB/Swiss-Prot Entry Name

STK4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK315238

GeneCard ID